Impact of Detection Mode in a Large Cohort of Women Taking Part in a Breast Screening Program

García-Aranda, Marilina; Redondo, Maximino; Zarcos, Irene; Louro, Javier; Rivas-Ruiz, Francisco; Téllez, Teresa; Pérez, Diego; Cano, Francisco Medina; Machan, Kenza; Domingo, Laia; Vernet, María del Mar; Padilla-Ruiz, María; Castells, Xavier; Sala, María

doi:10.4274/ejbh.galenos.2022.2021-11-8

Cited by 2 publications

(3 citation statements)

References 30 publications

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“…[37,38] In regard to the remaining variables found to be signi cant on the multivariate model, there is literature which shows and corroborates that, as in this study's results, older age and more advanced disease stages prognosticate worse survival. [39,40] In addition, according to the literature and in line with the high percentage of the presence of other comorbidities in this study sample (86.8%), female BCS can take on the pro le of a multimorbid patient. Therefore, comprehensive follow-up is necessary in which there is intervention from a coordinated clinical team that provides a response to each of the underlying complications.…”

Section: Discussionsupporting

confidence: 77%

Prevalence and Influence on Prognosis of Mental Health Comorbidities in Long-term Breast Cancer Survivors: Results From the Surbcan Study

Padilla‐Ruiz

Gimeno‐Miguel

Rivas‐Ruiz

et al. 2022

Preprint

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Aim The increase in survival of patients with breast cancer has largely been due to early detection and treatment advances, which has led to longer follow-up and treatment of these patients. The principal aim of this work is to describe the presence of mental health comorbidities and analyze their influence on survival in women who are long-term breast cancer survivors. Methods This retrospective multicenter cohort study is part of the SURBCAN Study, a cohort of 4,088 women who are long-term breast cancer survivors diagnosed between 2000 and 2006 who were followed-up on between 2012 and 2016. A descriptive analysis of the study population’s characteristics and prevalence of mental health comorbidities was performed. A Cox regression analysis was performed to study the influence of mental health comorbidity on all-cause mortality. Results A total of 42.2% of patients presented with at least one mental health comorbidity, notable among which were anxiety disorders and depression and mood disorders, with a prevalence of 37.6% and 21.1%, respectively. The presence of a mental health comorbidity was associated with a poor prognosis (HR: 2.13; 95% CI: 1.70–2.66), as was more advanced tumor stages. Conclusions The presence of mental health comorbidities in women who are long-term breast cancer survivors is associated with lower survival. Individualized follow-up in which the patient’s mental health status is specifically monitored is recommended.

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Section: Discussionsupporting

confidence: 77%

Prevalence and Influence on Prognosis of Mental Health Comorbidities in Long-term Breast Cancer Survivors: Results From the Surbcan Study

Padilla‐Ruiz

Gimeno‐Miguel

Rivas‐Ruiz

et al. 2022

Preprint

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“…This is controversial because the reason why screening should be independent prognostic factor survival is not well-understood and therefore drawing a credible quantitative conclusion as to the extent of survival advantage is not easy. However, it has been the focus of much research and the survival estimate we use [32] is similar to that reported by others who have shown the method of detection to be an independent prognostic factor [41][42][43][44]. Without this assumption in the model, PROCAS still remained an effective use of NHS resources compared to other risk-stratified screening regimens and to current screening, The model does not consider the budget or capacity implications of alternative screening regimens.…”

Section: Discussionmentioning

confidence: 73%

“…Women with cancer are assigned an age when it is detected from clinical symptoms upon entry into the model. Several observational studies support this assumption [31,32]. However, the absence of randomised controlled trials room for debate regarding the independent impact of mode of detection on survival and therefore this assumption is tested in sensitivity analysis.…”

Section: False Positives Can Occur Before Cancer Genesismentioning

confidence: 99%

The cost-effectiveness of risk-stratified breast cancer screening in the UK

Hill,

Kearns,

Pashayan

et al. 2023

Br J Cancer

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Background There has been growing interest in the UK and internationally of risk-stratified breast screening whereby individualised risk assessment may inform screening frequency, starting age, screening instrument used, or even decisions not to screen. This study evaluates the cost-effectiveness of eight proposals for risk-stratified screening regimens compared to both the current UK screening programme and no national screening. Methods A person-level microsimulation model was developed to estimate health-related quality of life, cancer survival and NHS costs over the lifetime of the female population eligible for screening in the UK. Results Compared with both the current screening programme and no screening, risk-stratified regimens generated additional costs and QALYs, and had a larger net health benefit. The likelihood of the current screening programme being the optimal scenario was less than 1%. No screening amongst the lowest risk group, and triannual, biennial and annual screening amongst the three higher risk groups was the optimal screening strategy from those evaluated. Conclusions We found that risk-stratified breast cancer screening has the potential to be beneficial for women at the population level, but the net health benefit will depend on the particular risk-based strategy.

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Impact of Detection Mode in a Large Cohort of Women Taking Part in a Breast Screening Program

Cited by 2 publications

References 30 publications

Prevalence and Influence on Prognosis of Mental Health Comorbidities in Long-term Breast Cancer Survivors: Results From the Surbcan Study

Prevalence and Influence on Prognosis of Mental Health Comorbidities in Long-term Breast Cancer Survivors: Results From the Surbcan Study

The cost-effectiveness of risk-stratified breast cancer screening in the UK

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