Impact of Depressive Symptoms on Memory for Emotional Words in Mild Cognitive Impairment and Late-Life Depression

Callahan, Brandy L.; Simard, Martine; Mouiha, Abderazzak; Rousseau, François; Laforce, Robert; Hudon, Carol

doi:10.3233/jad-150585

Cited by 16 publications

(28 citation statements)

References 56 publications

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“…2B, comparing positive-high arousal and negative-low arousal bars). In a broader sense, these results contribute to the literature of preserved emotion processing in late life, and memory preferences for positive information in healthy older adults (reviewed by Reed, Chan, and Mikels, 2014), and individuals with MCI (Callahan et al, 2016; Gorenc-Mahmutaj et al, 2015; Leal et al, 2016). …”

Section: Discussionsupporting

confidence: 51%

“…Another investigation of MCI patients’ recognition memory for emotional and neutral IAPS images showed higher true recognition and false alarms for negative compared to positive or neutral images, and also that dividing attention did not impact discrimination ability (Sava et al, 2016). In other studies MCI patients have shown a memory benefit for positive or negative words (Brueckner and Moritz, 2009; Callahan et al, 2016), but impaired memory for faces studied with emotional expressions (Wang et al, 2013; Werheid et al, 2010). A recent study examined recall and recognition memory for a short series of emotional pictures (8 of each positive, negative, neutral) in healthy older adults, MCI, and patients with unspecified diagnosis of ‘dementia’(Gorenc-Mahmutaj et al, 2015).…”

Section: Introductionmentioning

confidence: 82%

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Effects of mild cognitive impairment on emotional scene memory

et al. 2017

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Young and older adults experience benefits in attention and memory for emotional compared to neutral information, but this memory benefit is greatly diminished in Alzheimer’s disease (AD). Little is known about whether this impairment arises early or late in the time course between healthy aging and AD. This study compared memory for positive, negative, and neutral items with neutral backgrounds between patients with mild cognitive impairment (MCI) and healthy older adults. We also used a divided attention condition in older adults as a possible model for the deficits observed in MCI patients. Results showed a similar pattern of selective memory for emotional items while forgetting their backgrounds in older adults and MCI patients, but MCI patients had poorer memory overall. Dividing attention during encoding disproportionately reduced memory for backgrounds (versus items) relative to a full attention condition. Participants performing in the lower half on the divided attention task qualitatively and quantitatively mirrored the results in MCI patients. Exploratory analyses comparing lower- and higher-performing MCI patients showed that only higher-performing MCI patients had the characteristic scene memory pattern observed in healthy older adults. Together, these results suggest that the effects of emotion on memory are relatively well preserved for patients with MCI, although emotional memory patterns may start to be altered once memory deficits become more pronounced.

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Section: Discussionsupporting

confidence: 51%

Section: Introductionmentioning

confidence: 82%

Effects of mild cognitive impairment on emotional scene memory

et al. 2017

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“…In keeping with this observation, the neuropsychological, clinical, and neuroimaging instruments currently proposed to early differentiate LLD from AD remain challenging and to a certain extent debatable. Previous clinical studies tried to differentiate LLD from AD using neuropsychological tools; however, since LLD and AD patients may share the same cognitive deficits, including memory impairment, executive dysfunction, and slow processing speed, a general agreement about an univocal neuropsychological profile for LLD has not been achieved (Butters et al, 2000 ; Hohman et al, 2011 ; Rushing et al, 2014 ; Callahan et al, 2016 ). Thus, neuropsychological test may be considered sensitive but not specific for LLD diagnosis (Elderkin-Thompson et al, 2003 ; Beblo et al, 2011 ).…”

Section: Discussionmentioning

confidence: 99%

When Cognitive Decline and Depression Coexist in the Elderly: CSF Biomarkers Analysis Can Differentiate Alzheimer's Disease from Late-Life Depression

Liguori

Pierantozzi

Chiaravalloti

et al. 2018

Front. Aging Neurosci.

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Late-life depression (LLD) and Alzheimer's Disease (AD) are the two most frequent neuropsychiatric disorders affecting elderly. LLD and AD may clinically present with depressive and cognitive symptoms. Therefore, when cognitive decline is coupled with depression in the elderly, the differential diagnosis between LLD and AD could be challenging. The aim of the present study was to evaluate in a population of elderly patients affected by depression and dementia the usefulness of CSF AD biomarkers (tau proteins and β-amyloid42–Aβ42) and 2-[18F]fluoro-2-deoxy-d-glucose positron emission tomography (18FFDG-PET) in early differentiating LLD from AD. Two hundred and fifty-six depressed and demented patients, after performing CSF AD biomarkers and 18FFDG-PET, were distributed in two groups on the basis of the current diagnostic guidelines for AD (n = 201) and LLD (n = 55). Patients were then observed for 2 years to verify the early diagnosis. After the 2 year follow-up we compared AD and LLD patients' CSF and 18FFDG-PET data obtained at baseline to a group of age- and sex-matched controls. We found CSF Aβ42 levels significantly higher in LLD compared to AD patients. Remarkably, CSF Aβ42 levels of LLD patients (range between 550 and 1204 pg/mL) did not overlap with those of AD patients (range between 82 and 528 pg/mL). Moreover, we documented no differences in CSF AD biomarkers (Aβ42 and tau proteins) when comparing LLD patients to controls. In addition, AD patients showed the significant reduction of 18FFDG-PET uptake in temporo-parietal regions compared to both controls and LLD. Conversely, LLD and control groups did not differ at 18FFDG-PET analysis, although LLD patients showed heterogeneous patterns of glucose hypometabolism involving cortical and subcortical brain areas. It is noteworthy that at the end of the clinical follow-up, patients owing to AD group showed the expected significant decline of cognitive performances, whereas patients assigned to LLD group improved cognition as depressive symptoms recovered. Hence, in case of co-existence of cognitive impairment and depression in the elderly, we propose CSF AD biomarkers analysis to early differentiate LLD from AD and properly target the patient's therapeutic strategy and clinical follow-up.

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“…On tests of episodic memory, participants with aMCI/D+ obtain higher cued recall scores than those with aMCI (Hudon et al, 2008) but lower scores than are typically observed in LLD (Herrmann et al, 2007). However, not all studies have found memory differences between aMCI/D+ and aMCI, particularly when using free recall (Hudon et al, 2008;Callahan et al, 2016). It is necessary to clarify the circumstances under which memory is differentially affected in these groups.…”

Section: Introductionmentioning

confidence: 98%

“…One way to do this is using emotionally valenced information, as individuals with aMCI and LLD may exhibit different cognitive biases when processing emotional information. On the one hand, aMCI patients tend to remember more positive than negative (Marreneca et al, 2006;Werheid et al, 2010, experiment 3;Callahan et al, 2016) or neutral (Brueckner and Moritz, 2009;Nieuwenhuis-Mark et al, 2009;Waring et al, 2014;Gorenc-Mahmutaj et al, 2015;Callahan et al, 2016) items on memory tests involving emotional stimuli (but not always, Mistridis et al, 2013;Parra et al, 2013;Wang et al, 2013). On the other hand, LLD patients tend to allocate more cognitive resources to processing negative stimuli compared to positive or neutral information (Broomfield et al, 2007; but see Mah and Pollock, 2010).…”

Section: Introductionmentioning

confidence: 99%

Memory for emotional images differs according to the presence of depressive symptoms in individuals at risk for dementia

Callahan

Laforce

Dugas³

et al. 2016

Int. Psychogeriatr.

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Results support previous research suggesting that the neuropsychological profile of aMCI/D+ is different from that of aMCI and LLD. Although depressed and non-depressed individuals with aMCI recall comparable quantities of information, the quality of the recalled information differs significantly. On theoretical grounds, this suggests the existence of distinct neurobiological or neurofunctional manifestations in both groups. Practically, these differences may guide the development of personalized emotion-focused encoding strategies in cognitive training programs.

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Impact of Depressive Symptoms on Memory for Emotional Words in Mild Cognitive Impairment and Late-Life Depression

Cited by 16 publications

References 56 publications

Effects of mild cognitive impairment on emotional scene memory

Effects of mild cognitive impairment on emotional scene memory

When Cognitive Decline and Depression Coexist in the Elderly: CSF Biomarkers Analysis Can Differentiate Alzheimer's Disease from Late-Life Depression

Memory for emotional images differs according to the presence of depressive symptoms in individuals at risk for dementia

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