Impact of depression on multiple sclerosis patients

Leonavičius, Rytis; Adomaitienė, Virginija

doi:10.2478/s11536-012-0032-x

Cited by 15 publications

(15 citation statements)

References 31 publications

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“…Leonavicius et al [38] found sleep disturbances in 45.3 % of MS patients using the Medical Outcomes Study Sleep (MOSS) measure [39], and Tachibana et al [40] reported sleep problems in 53.6 % of MS patientsincluding discomfort in the legs, snoring, nocturia, and sleep apnea.…”

Section: Insomniamentioning

confidence: 99%

Sleep Disorders in Multiple Sclerosis. Review

Veauthier

2015

Curr Neurol Neurosci Rep

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Sleep disorders are common in patients with multiple sclerosis (MS) and play a crucial role in health and quality of life; however, they are often overlooked. The most important sleep disorders in this context are as follows: insomnia, restless legs syndrome, periodic limb movement disorders, and sleep-related breathing disorders (SRBD). It is unclear if MS-related processes (lesions, brain atrophy) can cause symptomatic forms of sleep apnea. MS-related narcolepsy-like symptoms are described in the literature and, in some cases, have resolved with methylprednisolone pulse therapy. Similarly, REM sleep behavior disorder (RBD) is very rare in MS, but it can be an initial sign of MS where cortisone therapy may be helpful and can be taken into account in this specific context. Independent diagnosis and treatment is required for all of the abovementioned conditions. Treating physicians and neurologists should be aware of these comorbidities and initiate specific therapy. Highly fatigued or sleepy MS patients should have polysomnography in order not to overlook these diagnoses.

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Section: Insomniamentioning

confidence: 99%

Sleep Disorders in Multiple Sclerosis. Review

Veauthier

2015

Curr Neurol Neurosci Rep

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“…Clinical studies have reported that sleep problems in MS are often under diagnosed [86], and may be related to daytime fatigue experienced by most of the patients [87]. There is also some evidence showing a positive correlation between the severity of the clinical picture and the presence of sleep problems [83], suggesting that the correction of sleep problems might help to improve the clinical conditions of MS patients. However, if this beneficial role of sleep is mediated by the mechanisms previously described on myelin and OPC proliferation remains unclear and needs further investigations.…”

Section: Oligodendrocytes and Opcs Pathology And Sleepmentioning

confidence: 99%

Sleep and Oligodendrocyte Functions

Bellesi

2015

Curr Sleep Medicine Rep

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Transcriptomic studies have revealed that the brains of sleeping and awake animals differ significantly at the molecular level, with hundreds of brain transcripts changing their expression across behavioral states. However, it was unclear how sleep affects specific cells types, such as oligodendrocytes, which make myelin in the healthy brain and in response to injury. In this review, I summarize the recent findings showing that several genes expressed at higher levels during sleep are involved in the synthesis/maintenance of all membranes and of myelin in particular. In addition, I will discuss the effect of sleep and wake on oligodendrocyte precursor cells (OPCs), providing a working hypothesis on the function of REM sleep and acetylcholine in OPC proliferation.

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“…The current study demonstrated that depression was prevalent in 18.8 percent of study participants and that it was in line with previous studies. [30][31][32][33][34] Pain was presented in 84.2 percent of depressed patients and it was significantly higher compared with not depressed (54.9 percent) participants of the study (p < 0.01). The mean value of depression (HADS-D score) in patients' group with pain was significantly higher compared with pain free patients (respectively, 9.8 AE 5.2 vs. 6.1 AE 4.5, p < 0.01).…”

Section: Discussionmentioning

confidence: 75%