Impact of depression on mental fatigue and attention in patients with multiple sclerosis

Takeda, Akitoshi; Minatani, Shinobu; Ishii, Akira; Matsuo, Takashi; Tanaka, Masaaki; Yoshikawa, Takahiro; Itoh, Yoshiaki

doi:10.1016/j.jadr.2021.100143

Cited by 5 publications

(4 citation statements)

References 32 publications

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“…Regarding the association between fatigue and depression, the study's findings align with some prior research [ 38 , 52 , 81 ]. A plausible explanation emerges from the neurophysiological perspective, suggesting that fatigue and depression in patients with MS share potential origins.…”

Section: Discussionsupporting

confidence: 87%

“…Common psychological issues linked to fatigue in MS patients include depression, anxiety [ 49 ], and stress [ 50 ]. Depression particularly influences mental fatigue [ 51 ], with research revealing a 3.6-fold increase in fatigue among depressed patients [ 52 ]. The use of stimulants and antidepressants has demonstrated a significant reduction in fatigue symptoms, emphasizing this strong connection [ 52 , 53 ].…”

Section: Introductionmentioning

confidence: 99%

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Sleep Disorders and Fatigue among Patients with MS: The Role of Depression, Stress, and Anxiety

Zekibakhsh Mohammadi,

Kianimoghadam,

Mikaeili

et al. 2024

Neurology Research International

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Sleep disorders and fatigue represent prominent symptoms frequently experienced by individuals with multiple sclerosis (MS). Some psychological factors such as depression, stress, and anxiety seem to have a relationship with such problems. This study aimed to examine the role of depression, stress, and anxiety in predicting sleep disorders and fatigue among patients with MS. Employing a cross-sectional descriptive-correlational design, the study involved a sample size of 252 participants selected through purposive sampling based on inclusion and exclusion criteria. We utilized a demographic information questionnaire along with the Mini-Sleep Questionnaire (MSQ), Fatigue Severity Scale (FSS), and Depression, Anxiety, and Stress Scale (DASS-21) to collect data and analyzed them applying SPSS22, incorporating statistical measures including Pearson correlation and regression. The results of the Pearson correlation coefficient showed that sleep disorders had a positive and significant relationship with depression (r = 0.56; P<0.001), stress (r = 0.40; P<0.001), and anxiety (r = 0.52; P<0.001). There was no significant relationship between age and the development of sleep disorders in total score (r = −0.001; P<0.985), but age had a relationship with insomnia (r = −0.146; P<0.021) and oversleeping (r = 0.153; P<0.015). Age and fatigue did not have a significant relationship as well (r = −0.044; P<0.941). In addition, fatigue had a positive and significant relationship with depression (r = 0.52; P<0.001), stress (r = 0.48; P<0.001), and anxiety (r = 0.54; P<0.001). The results of the regression analysis also showed that depression, stress, and anxiety predict 0.37% of the total variance of sleep disorders (F = 48.34; P<0.001) and 0.35% of the total variance of fatigue (F = 44.64; P<0.001). Our findings suggest that depression, stress, and anxiety play a significant role in predicting sleep disorders and fatigue among patients with MS. This study has been reported in accordance with the TREND checklist for nonrandomized trials.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Sleep Disorders and Fatigue among Patients with MS: The Role of Depression, Stress, and Anxiety

Zekibakhsh Mohammadi,

Kianimoghadam,

Mikaeili

et al. 2024

Neurology Research International

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“…Previous literature showed that fatigue and concentration difficulties are common symptoms in the MS population ( Raimo et al, 2022 ). Although some authors reported an association between fatigue and cognitive performance (e.g., Takeda et al, 2021 ), the potential role of fatigue appears to be limited ( Bol et al, 2010 ) or more relevant on sustained attention and alertness ( Hanken et al, 2015 ). Again, the results did not support the interpretation according to which fatigue is a determinant factor in pragmatic worsening, as PM showed worsened performance in pragmatic tasks also at the beginning of the testing session and, conversely, good performance in some neuropsychological tasks, even if at the end of the testing session.…”

Section: Discussionmentioning

confidence: 99%

Case report: Pragmatic impairment in multiple sclerosis after worsening of clinical symptoms

et al. 2022

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Pragmatics, defined as the ability to integrate language and context to communicate effectively, may be impaired in Multiple Sclerosis (MS). We present the case of a patient with active secondary progressive MS who, after a first neuropsychological assessment that evidenced only a slight pragmatic impairment, suffered a sudden worsening of her clinical conditions, treated with corticosteroids. After this clinical worsening, her pragmatic abilities declined markedly, both in comprehension and production. This worsening was accompanied by a decline only in one attention task, in the context of an overall stable cognitive functioning. We conclude that pragmatics may be a domain particularly susceptible to cognitive worsening, highlighting the importance of its assessment in clinical practice.

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“…Our study also shows that higher CMDI scores are associated with worse cognitive performance in PwMS. The relationship between depressive symptomatology and cognition has been well-established (for a review, see Arnett et al., 2008 ; Siegert & Abernethy, 2005 ), and it is more noteworthy in “cognitively effortful” tasks that require information processing speed, attention, working memory, and executive functions ( Arnett, Higginson, Voss, Bender, et al., 1999 ; Arnett, Higginson, Voss, Wright, et al., 1999 ; Arnett et al., 2008 ; Arnett, Higginson, & Randolph, 2001 ; Diamond et al., 2008 ; Hoffmeister et al., 2021 ; Takeda et al., 2021 ). In agreement with these previous studies, we observed that the inverse correlations between CMDI scores and performance on the PASAT and SDMT were larger than those observed for other cognitive tests.…”

Section: Discussionmentioning

confidence: 99%

Multiple Sclerosis and Depression: Translation and Adaptation of the Spanish Version of the Chicago Multiscale Depression Inventory and the Study of Factors Associated with Depressive Symptoms

Sanchis-Segura

Cruz-Gómez

Esbrí

et al. 2022

Archives of Clinical Neuropsychology

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Objective Depressive disorder occurs in up to 50% of persons with Multiple Sclerosis (PwMS). Accurate assessment of depression in MS is essential in clinical settings because depressive symptomatology can affect the clinical course of the disease. Methods We translated, adapted, and tested the Spanish version of the Chicago Multiscale Depression Inventory (CMDI), a specific test to assess depression in neurological disorders. We compare our results with those obtained with previous versions of the questionnaire (English and Italian). Finally, we also analyze the relationship between the results obtained on the CMDI and demographic, clinical, and cognitive variables. Results The results obtained with the Spanish version of the CMDI were similar to those observed in previous published versions. We also observed higher depression scores in PwMS (especially in progressive forms) compared with healthy controls. Moreover, depression symptomatology was related to higher disability and fatigue and worse cognitive performance in PwMS. Conclusions The results support the validity of the CDMI in the Spanish population, as well as the association between depression and other characteristic symptoms of MS. These findings also emphasize the importance of good assessment and multidisciplinary treatment of depression in PwMS.

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Impact of depression on mental fatigue and attention in patients with multiple sclerosis

Cited by 5 publications

References 32 publications

Sleep Disorders and Fatigue among Patients with MS: The Role of Depression, Stress, and Anxiety

Sleep Disorders and Fatigue among Patients with MS: The Role of Depression, Stress, and Anxiety

Case report: Pragmatic impairment in multiple sclerosis after worsening of clinical symptoms

Multiple Sclerosis and Depression: Translation and Adaptation of the Spanish Version of the Chicago Multiscale Depression Inventory and the Study of Factors Associated with Depressive Symptoms

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