Impact of Depression on Health and Medical Care Utilization and Expenses in US Adults With Migraine: A Retrospective Cross Sectional Study

Wu, Jun; Davis–Ajami, Mary Lynn; Zhiqiang, Liang

doi:10.1111/head.12871

Cited by 21 publications

(38 citation statements)

References 41 publications

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“…These observed cost differences appear to reflect both the increased disease severity and the increased rates of comorbidities in chronic migraine compared with episodic migraine . For example, depression increased the likelihood of all‐cause emergency department visits, and was associated with higher total and migraine‐related health expenses …”

Section: Burden Of Diseasementioning

confidence: 99%

Migraine Burden of Disease: From the Patient's Experience to a Socio‐Economic View

2018

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Migraine is one of the most common diseases worldwide and, importantly, a major cause of disability. This translates into a huge clinical and economic burden to individuals and society. Despite existing data on how migraine affects populations, the disease continues to be underdiagnosed and therefore undertreated, so the scale of the public health problem may be underestimated. The impact on the daily lives of patients and their families has also been underappreciated. Clinical and regulatory guidelines are encouraging the use of patient-reported outcome tools (PROs), as these may help in disease management and facilitate physician-patient interactions. In clinical trials in migraine, PRO data are key to evaluating the effects of new therapies on patients, such as disability assessment, productivity, quality of life, and emotional and physical functioning. Digital technologies have enabled the development of ePRO tools, which may play a growing role in the collection of PRO data in the future. Here, we will consider the current view of the burden imposed by migraine on patients and society, illustrate this with two patient case studies, and examine the initiatives underway to use our knowledge to improve our management approaches for the disease.

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Section: Burden Of Diseasementioning

confidence: 99%

Migraine Burden of Disease: From the Patient's Experience to a Socio‐Economic View

2018

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“…Seven studies gave data for the disability outcome for adults with migraine and comorbid depression and/or anxiety ( Table 3). The results from the studies included in this review showed that depression and anxiety had a negative impact on the disability depression compared to those without depression (OR=1.36, 95% CI: 1.08, 1.71) [29]. This study suggests that depression increases healthcare utilization among adults with migraine, however, the impact of anxiety alone or comorbid depression and anxiety on healthcare utilization not been evaluated yet.…”

Section: Humanistic Burden Of Comorbid Depression and Anxiety Among Amentioning

confidence: 71%

“…These studies found that that direct medical care costs were higher for those with depression and/or anxiety. In terms of healthcare utilization, only one study identified in this review was used a large national U.S. data, this study have reported that adults with migraine and depression have a significantly higher hospitalizations ( [29]. The higher healthcare utilization could be due to that depression may exacerbate migraine symptoms and increase the need for healthcare utilization and migraine treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Although there were no limitations on the year of publication, studies only started to emerge since 2000. Nineteen studies examined the humanistic burden, twelve examined HRQoL [1,7,[14][15][16][17][18][19][20][21][22][23][24] and seven examined disability [7,17,[24][25][26][27][28] and two studies assessed the economic burden, three studies examine the healthcare cost [9,29,30] and medical services utilization [4,29]. All studies employed validated measures of migraine, HRQoL, depression, and anxiety.…”

Section: General Characteristics Of Included Studiesmentioning

confidence: 99%

“…The economic burden was measured with the direct medical costs related to medical resource utilization of inpatient, outpatient and pharmaceutical services for treating adults with migraine. The current evidence among adults with migraine reported that individuals with comorbid depression and/or anxiety have higher healthcare costs[9,29,30] and medical services utilization[29] than those without these comorbid mental health conditions. Pesa et al examined the direct healthcare cost of comorbid depression and/or anxiety among individuals with migraine using retrospective employer database[9].…”

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confidence: 99%

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Humanistic and Economic Burden of Depression and Anxiety among Adults with Migraine: A systematic review

Alwhaibi¹

2020

Preprint

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Background Depression and anxiety are highly prevalent disabling chronic conditions among adults with migraine. These comorbid conditions are becoming a well-recognized public health problem in many countries due to their humanistic and economic burden.Objectives This review was conducted to assess systematically the humanistic and financial burden of migraine and depression and/or anxiety disorder among adults with migraine.Methods A systematic literature search conducted using MedLine and CINAHL via EBSCO, OVID and Cochrane Database of Systematic Reviews via OVID. Studies evaluating the humanistic burden (disability and Health-related Quality of Life (HRQoL)) and the economic burden and healthcare utilization of comorbid depression and anxiety among adults with migraine that were published in peer-reviewed English language journals from inception until August 2019 were included.Results Of the 957 articles identified, 24 studies were included in the review. HRQoL was measured using generic, and migraine-specific measures. Regarding the humanistic burden, twelve studies reported an association between depression and/or anxiety and lower HRQoL and seven studies reported an association between depression and/or anxiety and higher disability. Regarding the economic burden, only two studies were identified and both found that depression and/or anxiety are associated with higher healthcare expenditures and utilization among adults with migraine.Conclusions These results of this review highlight the substantial impact of depression and/or anxiety on HRQoL, disability, healthcare cost and utilization of medical services for adults with migraine. It is important for healthcare providers to be aware of the negative impact of these illnesses and identify and treat anxiety and depression as treatment may have a potential to improve the health outcomes of patients living with migraine.

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Humanistic and economic burden of depression and anxiety among adults with migraine: A systematic review

Alwhaibi

Alhawassi

2020

Depress Anxiety

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Background Depression and anxiety are well‐recognized comorbid health conditions among adults with migraine due to their humanistic and economic burden. This review was conducted to systematically assess the humanistic and economic burden of comorbid depression and/or anxiety disorder among adults with migraine. Methods A systematic literature search was conducted using MEDLINE and CINAHL via EBSCO, EMBASE, and Cochrane Database of Systematic Reviews via OVID. Studies evaluating the humanistic burden and the economic burden of comorbid depression and anxiety among adults with migraine that were published in peer‐reviewed English language journals from inception until January 2020 were included. Results Out of the 640 identified articles, 23 studies were found eligible and included in this review. Regarding the humanistic burden, health‐related quality of life (HRQoL) was examined by 11 studies, 7 studies examined disability, while 2 studies evaluated both HRQoL and disability measures. These studies reported an association between depression and/or anxiety and lower HRQoL and higher disability among adults with migraine. Regarding the economic burden, only three studies were identified and all concluded that depression and/or anxiety are significantly associated with higher healthcare expenditures and utilization among adults with migraine. Conclusions Results of this review highlight the substantial burden of depression and/or anxiety for adults with migraine. Healthcare providers need to identify and treat anxiety and depression for patients living with migraine.

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Impact of Depression on Health and Medical Care Utilization and Expenses in US Adults With Migraine: A Retrospective Cross Sectional Study

Cited by 21 publications

References 41 publications

Migraine Burden of Disease: From the Patient's Experience to a Socio‐Economic View

Migraine Burden of Disease: From the Patient's Experience to a Socio‐Economic View

Humanistic and Economic Burden of Depression and Anxiety among Adults with Migraine: A systematic review

Humanistic and economic burden of depression and anxiety among adults with migraine: A systematic review

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