Impact of depression on clinical outcomes following percutaneous coronary intervention: a systematic review and meta-analysis

Abstract

ObjectivesThe objective of this meta-analysis was to assess whether depression in percutaneous coronary intervention (PCI) patients is associated with higher risk of adverse outcomes.DesignSystematic review and meta-analysis.MethodsEMBASE, PubMed, CINAHL and PsycINFO were searched as data sources. We selected prospective cohort studies evaluating the relationship between depression and any adverse medical outcome, including all-cause mortality, cardiac mortality and non-fatal events, from inception to 28 February 2019. Two reviewers independently extracted information and calculated the risk of cardiovascular events in patients with preoperative or postoperative depression compared with non-depressed patients.ResultsEight studies (n=3297) met our inclusion criteria. Most studies found a positive association between depression and adverse cardiovascular outcomes. Meta-analysis yielded an aggregate risk ratio of 1.57 (95% CI 1.28 to 1.92, p<0.0001) for the magnitude of the relation between depression and adverse outcomes.ConclusionsOur systematic review and meta-analysis suggests that depression is associated with an increased risk of worse clinical outcome or mortality in patients undergoing PCI. Assessment time and length of follow-up do not have a significant effect on this conclusion.

2021 ESC Guidelines on cardiovascular disease prevention in clinical practice: Developed by the Task Force for cardiovascular disease prevention in clinical practice with representatives of the European Society of Cardiology and 12 medical societies With the special contribution of the European Association of Preventive Cardiology (EAPC)

“…The 12-month prevalence of mental disorders in CVD patients is around 40%, leading to significantly worse prognosis. 100,108,303,304 The onset of CVD increases the risk of committing suicide. 305 In this context, awareness of anxiety and depression symptoms should be increased.…”

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“…Des Weiteren zeigt sich eine Sorge vor beruflichen und privaten Belastungssituationen, die zu einer chronifizierten Stressbelastung führen kann. Dabei weist diese einen vergleichbar hohen negativen prognostischen Wert wie traditionelle kardiovaskuläre Risikofaktoren (HR 1,57 für Depression, 95 %-KI 1,28-1,92) auf [24]. Durch Screening-Fragebögen (z.…”

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“…And a multicenter prospective study show that depression is associated with an increased risk for MACEs post-PCI, independent of anxiety [2] . The results of a meta-analysis show that depressed individuals in post-PCI have a 57% greater risk of poor outcome than nondepressed patients [9] …”

“…[ 2 ] The results of a meta-analysis show that depressed individuals in post-PCI have a 57% greater risk of poor outcome than nondepressed patients. [ 9 ]…”