This study aimed to investigate the relationship between job stress, burnout, and intention to leave, moderated by empathic concern and perspective‐taking. The data were collected via the Maslach Burnout Inventory‐Human Services Survey (MBI‐HSS), Interpersonal Reactivity Index (IRI) measuring perspective‐taking and empathic concern, Spielberger's Professional Stress Questionnaire, and a questionnaire measuring intention to leave. Medical doctors, nurses, and psychologists working in addiction facilities were surveyed. The results showed that, independently, job stress increases burnout and intention to leave. In addition, either cognitive or emotional factors of empathy prevent burnout and intention to leave; however, the preventing effect of each is reduced when they interact. Moreover, perspective‐taking enhances the effect of job stress on intention to leave. This twofold effect of empathy for burnout and intention to leave provides practical implications for health‐care professionals.