Impact of demographic, environmental, and lifestyle factors on vitamin D sufficiency in 9084 Japanese adults

Nakamura, Kazutoshi; Kitamura, Kaori; Takachi, Ribeka; Saito, Toshiko; Kobayashi, Ryosaku; Oshiki, Rieko; Watanabe, Yasuyoshi; Tsugane, Shoichiro; Sasaki, Ayako

doi:10.1016/j.bone.2014.12.064

Cited by 80 publications

(63 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study, we first confirmed that the mean serum 25(OH)D level in PH patients was lower than that in the Japanese adult population [19], and that this difference was more marked in our PAH patient subgroup. Furthermore, 95.1% of PH patients had vitamin D insufficiency, and 61.0% had vitamin D deficiency, and we found statistically significant relationships between serum 25(OH)D levels and hemodynamics assessed by right heart catheterization in our PH patient cohort.…”

Section: Discussionsupporting

confidence: 75%

“…The reported mean 25(OH)D level in Japanese adults is 20.0 ng/mL (49.9 nmol/L) [19], compared to 18.5 ± 1.0 ng/mL for the PH patients studied herein (Table 1 and Fig 1A). Intriguingly, the PAH subgroup of patients had lower serum 25(OH)D levels than the CTEPH group (13.1 ± 1.5 ng/mL in PAH vs. 20.7 ± 1.0 ng/mL in CTEPH, P < 0.001) (Table 1 and Fig 1A).…”

Section: Resultsmentioning

confidence: 76%

See 1 more Smart Citation

Therapeutic impact of dietary vitamin D supplementation for preventing right ventricular remodeling and improving survival in pulmonary hypertension

et al. 2017

View full text Add to dashboard Cite

BackgroundPulmonary hypertension (PH), caused by elevated pulmonary vascular resistance, leads to right heart failure and ultimately death. Vitamin D deficiency can predispose individuals to hypertension and left ventricular dysfunction; however, it remains unknown how serum vitamin D level is related to PH and right ventricular (RV) dysfunction.MethodsSerum 25-hydroxyvitamin D [25(OH)D] levels were assessed in PH patients for an association with disease severity. To examine whether vitamin D supplementation could prevent the development of pulmonary vascular remodeling and RV dysfunction in PH, a rat model of PH was fed either normal chow or a high vitamin D diet.ResultsThe majority (95.1%) of PH patients had 25(OH)D levels in the insufficiency range, which is associated with increased mean pulmonary artery pressure, increased pulmonary vascular resistance, and decreased cardiac output in PH patients. Vitamin D supplementation significantly increased serum 25(OH)D levels and improved survival in PH rats. Interestingly, while the supplemented rats retained the typical increases in medial thickness of the muscular pulmonary arteries and RV systolic pressure, RV cardiomyocyte hypertrophy and B-type natriuretic peptide expression was significantly attenuated.ConclusionsVitamin D deficiency is frequently seen in patients diagnosed with PH and low serum levels of 25(OH)D are associated with severity of PH and RV dysfunction. Vitamin D supplementation in PH rats improved survival via ameliorating pathological RV hypertrophy. These findings suggest an insufficient intake of vitamin D might potentially accelerate RV dysfunction, leading to a crucial clinical impact of vitamin D supplementation in PH.

show abstract

Section: Discussionsupporting

confidence: 75%

Section: Resultsmentioning

confidence: 76%

Therapeutic impact of dietary vitamin D supplementation for preventing right ventricular remodeling and improving survival in pulmonary hypertension

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Our results showed a positive correlation between age and serum 25OHD levels for both the males and females. Age was shown to be positively associated with 25OHD levels in previous reports [15,55]. Lower serum 25OHD levels in younger individuals has been suggested to be associated with their lower forearm bone mineral content [15].…”

Section: Vitamin D Deficiency and Night Shift Work O R I G I N A L P mentioning

confidence: 80%

“…This clearance has been suggested to be through enhanced uptake by adipose tissue [67], which results in lower bioavailability of 25OHD from cutaneous and dietary sources due to its deposition in body fat compartments [59]. Other study has suggested that and Japan have shown that 25OHD deficiency is largely attributed to female sex [18,55]. The overall night workers had significantly lower mean 25OHD levels (21 ng/ml, SD = 12) compared to the day workers (28 ng/ml, SD = 14).…”

Section: Vitamin D Deficiency and Night Shift Work O R I G I N A L P mentioning

confidence: 99%

Determinants of vitamin D status among Jordanian employees: Focus on the night shift effect

Alefishat¹,

Farha²

2016

Int J Occup Med Environ Health

View full text Add to dashboard Cite

Objectives: To assess the association between night work and 25-hydroxy vitamin D (25OHD) levels, and to evaluate effect of potential risk factors on 25OHD levels. Material and Methods: A total of 140 adult Jordanian employees were recruited. Demographic, lifestyle and working patterns data were documented through a well-structured questionnaire. Vitamin D status was assessed by measuring circulating concentrations of 25OHD. Results: Mean 25OHD level was 23.8 ng/ml. No significant difference was found in 25OHD levels between the summer and winter (p = 0.46), or between males and females (p = 0.35). The female night workers had significantly lower serum 25OHD levels compared to the female day workers (p = 0.01). No significant difference in serum 25OHD levels was found between the night and day male workers (p = 0.25). The number of night shifts/month was negatively correlated with 25OHD levels in both the males and females (p = 0.01 and p = 0.007, respectively). Age was positively correlated with 25OHD levels in both the males and females (p = 0.02 and p = 0.001, respectively). Body mass index was negatively associated with 25OHD levels in the whole sample (p = 0.03), but not within each gender group (p = 0.21 for the males and p = 0.09 for the females). Smoking had no significant association with 25OHD levels (p = 0.99 for the males and p = 0.22 for the females). Conclusions: Our results suggest that women working night shifts are at higher risk of 25OHD deficiency, and, consequently, of other health problems linked to 25OHD deficiency. Int J Occup Med Environ Health 2016;29(5):859-870

show abstract

“…While the specific questions used were not individually validated against adolescent plasma 25(OH)D, previous studies have suggested a positive association between plasma vitamin D and lighter skin, [13] less frequent sunscreen use, [14] [15] and tanning bed use [16] and we hypothesize that girls with more frequent sunburns are likely to have greater vitamin D exposure. We asked participants about the color of their untanned skin (very fair, fair, olive, or dark).…”

Section: Methodsmentioning

confidence: 99%

Adolescent dietary vitamin D and sun exposure in relation to benign breast disease

Boeke

Tamimi

Berkey

et al. 2015

Cancer Causes Control

View full text Add to dashboard Cite

Purpose Vitamin D may reduce cell proliferation and tumor growth in breast tissue, and exposure may be most important during adolescence when breast tissue is developing. In the Nurses’ Health Study II, higher recalled adolescent vitamin D intake was associated with a lower risk of benign breast disease (BBD). Our study aim was to assess adolescent vitamin D exposure in relation to BBD in young women. Methods Vitamin D was assessed in 6,593 adolescent girls (9 to 15 years of age at baseline) in the prospective Growing Up Today Study cohort using the mean energy-adjusted intakes from food frequency questionnaires in 1996, 1997, and 1998. In 1999, 5286 girls reported skin color, sunscreen use, tanning bed use, and number of sunburns in the past year, and we used state of residence to assess low vs. high ultraviolet (UV) index. Biopsy-confirmed BBD was reported on questionnaires in 2005, 2007, and 2010 (n=122). Results Dietary vitamin D, tanning behaviors, and other sun exposure variables were not significantly associated with BBD in logistic regression models adjusted for age, family history of breast cancer or BBD, age at menarche, nulliparity, alcohol intake, body mass index, and physical activity. The relative risk for the top (>467 IU/day) vs. bottom (<243 IU/day) quartile of vitamin D intake was 0.76 (95% CI: 0.47, 1.23). Conclusions Sun exposure was not significantly associated with BBD in this prospective cohort study. However, a suggestive inverse association between dietary vitamin D and BBD was observed that merits further study.

show abstract

Impact of demographic, environmental, and lifestyle factors on vitamin D sufficiency in 9084 Japanese adults

Cited by 80 publications

References 37 publications

Therapeutic impact of dietary vitamin D supplementation for preventing right ventricular remodeling and improving survival in pulmonary hypertension

Therapeutic impact of dietary vitamin D supplementation for preventing right ventricular remodeling and improving survival in pulmonary hypertension

Determinants of vitamin D status among Jordanian employees: Focus on the night shift effect

Adolescent dietary vitamin D and sun exposure in relation to benign breast disease

Contact Info

Product

Resources

About