Impact of delayed radiotherapy on local control in node-negative breast cancer patients treated with breast-conserving surgery and adjuvant radiotherapy without chemotherapy

Abstract

Early radiotherapy within 6 weeks of breast-conserving surgery is associated with increased local control in patients with node-negative breast cancer not undergoing chemotherapy.

Impact of time interval between radical hysterectomy with pelvic node dissection and initial adjuvant therapy on oncological outcomes of early stage cervical cancer

“…The impact of the TI from surgery to adjuvant therapy (radiation or concurrent chemoradiation) has been studied mainly in breast, endometrial, and head and neck cancers [101112132223]. Several retrospective cohort studies have found that a longer TI is associated with poor oncological outcomes of these cancers [10111222]. Recently, a study in 308 endometrial cancer patients found that delay (≥9 weeks) in beginning adjuvant RT after hysterectomy was associated with poor survival outcomes [23].…”

Effect of Delayed Adjuvant Radiotherapy in Early Breast Cancer on Local Control, Distant Metastasis and Overall Survival: an Evidence-Based Case Report

“…11 In addition, Kim et al and Pinnaro et al also gave insignficant result (p = 0.51, p = 0.27) respectively. 13,20 In contrary, Jobsen et al study concluded that there was significant difference in DMFS between delayed vs non delayed radiotherapy with HR 0.3 (0.2-0.5), p < 0.001. Jobsen et al suggest to start radiotherapy 36 days after surgery which might be lead to 40-70% relative survival benefit.…”

“…Fifteen article, Barbieri V et al, 6 Benchalal M et al, 7 Benk V et al, 8 Cefaro GA et al, 9 Corradini S et al, 10 Hebert-Croteau N et al, 11 Jobsen JJ et al, 12 Kim K et al, 13 Knauerhase H et al, 14 Seneviratne S et al, 15 Campos R et al, 16 Mikeljevic J et al, 17 Hershman DL et al, 18 Donato V et al, 19 Pinnaro P et al 20 were each appraised in groups by 2 authors using standardized validity criteria for prognostic research. Several aspects were critically reviewed comprising of its validity, importance, and applicability.…”

“…For example, Kyubo et al and Knauerhause et al which reported significant results used smaller sample size compared to Benchalal et al, S Coradini et al and JJ Jobsen et al which had more than 500 participants. 13,14 The way of applying the cut off to categorize early versus delayed time to radiation were vary among studies. In this case, study which applied the exposure in numerical variable was more reliable to quantify the time to radiation.…”

“…6,10 Only study form Kyobo Kim et al confirmed that SRI time (<6 weeks) lead to better local control after multivariate analysis performed. 13 Overall Survival…”