Impact of cyclosporine A use in the prevention of reperfusion injury in acute myocardial infarction: A meta-analysis

Upadhaya, Sunil; Madala, Seetharamprasad; Baniya, Ramkaji; Subedi, Suresh; Saginala, Kalyan; Bachuwa, Ghassan

doi:10.5603/cj.a2016.0091

Cited by 16 publications

(11 citation statements)

References 36 publications

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“…In the past decade, several in vitro and in vivo studies have confirmed the involvement of MPT in ischemia/RI [83]. The administration of CsA (as well as its analog FK506) has been shown to protect against ischemia/RI in multiple animal models and in multiple tissues, including cardiac and skeletal muscle, brain, kidney, liver, lungs, and testis [84][85][86][87][88][89]. Ppif -KO mice are significantly protected from ischemia/RI in both cardiac muscle and the brain, in terms of both tissue function and survival rates [31,32,90].…”

Section: Role Of Mpt In Reperfusion Injurymentioning

confidence: 98%

Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology

et al. 2020

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Mitochondrial permeability transition (MPT) is the sudden loss in the permeability of the inner mitochondrial membrane (IMM) to low-molecular-weight solutes. Due to osmotic forces, MPT is paralleled by a massive influx of water into the mitochondrial matrix, eventually leading to the structural collapse of the organelle. Thus, MPT can initiate outer-mitochondrial-membrane permeabilization (MOMP), promoting the activation of the apoptotic caspase cascade and caspase-independent cell-death mechanisms. The induction of MPT is mostly dependent on mitochondrial reactive oxygen species (ROS) and Ca2+, but is also dependent on the metabolic stage of the affected cell and signaling events. Therefore, since its discovery in the late 1970s, the role of MPT in human pathology has been heavily investigated. Here, we summarize the most significant findings corroborating a role for MPT in the etiology of a spectrum of human diseases, including diseases characterized by acute or chronic loss of adult cells and those characterized by neoplastic initiation.

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Section: Role Of Mpt In Reperfusion Injurymentioning

confidence: 98%

Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology

et al. 2020

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“…Cyclosporine A, a known MPTP desensitiser, has been shown to induce appreciable protection in acute myocardial infarction [33]. However, a recent meta-analysis failed to show any benefit of cyclosporine A post-infarction [34]. Other forms of preconditioning have also been suggested in an attempt to inhibit MPTP formation have shown some promise in animal studies [35–37].…”

Section: Primary Graft Dysfunctionmentioning

confidence: 99%

Primary graft dysfunction after heart transplantation: a thorn amongst the roses

et al. 2019

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Primary graft dysfunction (PGD) remains the leading cause of early mortality post-heart transplantation. Despite improvements in mechanical circulatory support and critical care measures, the rate of PGD remains significant. A recent consensus statement by the International Society of Heart and Lung Transplantation (ISHLT) has formulated a definition for PGD. Five years on, we look at current concepts and future directions of PGD in the current era of transplantation.

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“…Side branch occlusion, atherosclerotic debris embolization and ischemia/reperfusion injury are the main reasons for PCIrelated myocardial injury. Various adjunctive pharmacological agents and methods have been tried to reduce ischemia reperfusion injury but none of them have been proven (14)(15)(16) . Remote ischemic preconditioning is an easy, cheap, and practical method.…”

Section: Discussionmentioning

confidence: 99%

Long-term Results of One Cycle of Remote Ischemic Preconditioning Applied Before Elective Percutaneous Coronary Intervention

Yılmaztepe¹,

Taylan²,

Uçar³

et al. 2018

Kosuyolu Heart Journal

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Introduction: Myocardial injury after percutaneous coronary intervention (PCI) is seen frequently. Ischemia/ reperfusion injury, side branch occlusion and distal embolization of atherothrombotic debris are the main causes of myocardial injury. Remote ischemic preconditioning (RIPC) is a promising technique for protection from ischemia/reperfusion injury, but sufficient data of long-term clinical outcomes is not available. In this study we planned to investigate the effect of one cycle of RIPC on major cardiovascular events one year after elective PCI.Patients and Methods: 102 patients, undergoing elective PCI, with normal baseline cTroponin-I (cTn-I) values, were randomized equally into two groups. Five minutes of ischemic preconditioning was applied before the intervention to the preconditioning group, by inflating blood pressure cuff up-to 200 mmHg on nondominant arm. After 1 year, the clinical outcomes of these patients (angina, heart failure, death, myocardial infarction, repeat revascularization) were questioned.Results: From a total of 102 patients, 90 could be reached after an year. The mean duration of follow-up was 432 vs. 423.5 days (p= 0.793). Post-PCI 16 th hour cTn-I was insignificantly lower in the preconditioning arm (0.079 μg/L vs. 0.069 μg/L, p= 0.074). The incidence of cTn-I elevation 5 fold above the URL (> 0.115 μg/L) was lower in the preconditioning group; however, it was also insignificant (24.4% vs. 13.3%, p= 0.301). Death, MI or repeat revascularization rates did not differ between the groups. Conclusion:One cycle of RIPC had no effect on major cardiovascular events (MACE) after elective PCI.

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Impact of cyclosporine A use in the prevention of reperfusion injury in acute myocardial infarction: A meta-analysis

Cited by 16 publications

References 36 publications

Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology

Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology

Primary graft dysfunction after heart transplantation: a thorn amongst the roses

Long-term Results of One Cycle of Remote Ischemic Preconditioning Applied Before Elective Percutaneous Coronary Intervention

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