Impact of curcumin on fatty acid metabolism

Nosrati‐Oskouie, Mohammad; Aghili-Moghaddam, Nazanin Sadat; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

doi:10.1002/ptr.7105

Cited by 17 publications

(8 citation statements)

References 92 publications

(143 reference statements)

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“…In previous studies [23,24] ,Curcumae Radix has been shown to modulate glucose and lipid metabolism, but its in uence on energy metabolism has not been demonstrated for neurodegenerative diseases. Since apoptosis due to the toxicity of Curcumae Radix can affect energy metabolism [25,26], apoptosis-related markers were measured in mouse cerebrum and mouse tumor cells, and we found that Curcumae Radix did not cause neuronal damage.…”

Section: Discussionmentioning

confidence: 99%

Curcumae Radix Extract Reduces Beta-Amyloid (Αβ) and Tau Protein Through Increased Mitochondrial Respiration

Yang

Heo

et al. 2021

Preprint

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Background: Neurodegenerative diseases are increasingly being studied owing to the increasing proportion of the aging population. Several potential compounds have been studied to prevent neurodegenerative diseases, one of which is Curcumae Radix that is known to be beneficial for inflammatory conditions, metabolic syndrome, and various types of pain. However, it is not well studied and its influence on energy metabolism in neurodegenerative diseases is unclear. We focused on the relationship between neurodegenerative diseases and energy metabolism through Curcumae Radix extract in an animal model. Methods: Mice were treated with Curcumae Radix extract for 5 weeks orally 5 times in a week (50 mg/kg body weight). Murine delayed brain tumor (DBT) cells were supplemented with Curcumae Radix extract. We monitored the neurodegenerative makers and metabolic indicators using Western blotting and qRT-PCR and then assessed the cellular glycolysis and mitochondrial respiration through metabolic flux assay.Results: Low expression levels of Alzheimer’s disease-related markers were observed after treatment with Curcumae Radix extract. It was determined through the pAMPK/AMPK ratio that the ATP state was sufficient in the cerebrum and brain tumor cells. With this, an increase in glycolysis would be expected as glucose is the main energy source of the brain. However, glycolysis-related genes and the extracellular acidification rate showed that glycolysis decreased. Despite this, basal respiration and ATP production through mitochondrial respiration and increased TCA cycle and OXPHOS-related genes were observed in the Curcumae Radix group. Conclusions: In neurodegenerative diseases involving mitochondrial dysfunction, Curcumae Radix may act as a metabolic modulator of brain health to treat and prevent these diseases.

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Section: Discussionmentioning

confidence: 99%

Curcumae Radix Extract Reduces Beta-Amyloid (Αβ) and Tau Protein Through Increased Mitochondrial Respiration

Yang

Heo

et al. 2021

Preprint

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“…However, gastrointestinal symptoms can be observed, such as bloating, nausea, and diarrhea. Allergic reactions have also been reported 75,76 .…”

Section: Bioavailability and Adverse Effects Of Curcuma Longamentioning

confidence: 95%

The Effects of Curcuma Longa on the Osteoarthritis: A Systematic Review of Placebo-Controlled Clinical Studies

Alvarenga

Marconato

Fracaro

et al. 2022

MRAJ

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Osteoarthritis (OA) is a joint disorder characterized by chronic, degenerative, and irreversible inflammation leading to pain and disability. The standard drugs are ineffective for many patients and are usually associated with numerous side effects such as gastrointestinal complaints. Curcuma longa and its bioactive compounds have been considered for OA. The objective of this study was to perform a systematic review of the effects of Curcuma longa and its derivatives on OA. Pubmed, Cochrane, and Embase were searched, and PRISMA guidelines were followed to build this review. Only Randomized Clinical Trials (RCTs) that performed placebo-comparison were included. Most included studies showed that Curcuma longa or formulations prepared with curcuminoids can benefit the OA scores such as Visual Analog Scale, Knee injury and Osteoarthritis Outcome Score, Western Ontario and McMaster Universities Osteoarthritis Index; and Lequesne's pain functional index. The use of Curcuma longa extracts or curcuminoids can benefit patients with OA. Nevertheless, the available RCTs show treatment time, doses, and formulations heterogeneity. Thus, the standardization of RCTs can guide researchers and physicians on the dosages and formulations that are most effective in addressing this condition, which is very prevalent in the world's populations.

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“…Curcumin is a characteristic component of CLR and exhibits anti-infammatory, antioxidation, antitumor, and immunoregulatory properties. Moreover, it improves insulin resistance, obesity, and other FFA-related diseases [11,[28][29][30][31]. In this study, isoquercetin and rutin were also screened as representative compounds.…”

Section: Identifcation Of Prototypes and Metabolites Of Xrg-4 Inmentioning

confidence: 99%

Chemicolome and Metabolome Profiling of Xieriga-4 Decoction, A Traditional Mongolian Medicine, Using the UPLC-QTOF/MS Approach

ZhiGui

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Xieriga-4 decoction (XRG-4) is a classic prescription Mongolian medicine that has potent diuretic and anti-inflammatory activities. However, its functional components remain unknown. Purpose. This study aimed to identify the chemical components in XRG-4 and its metabolome in vivo. Methods. An ultra-performance liquid chromatography coupled with a quadrupole time-of-flight tandem mass spectrometry based approach was proposed to systematically profile the chemicolome and metabolome of XRG-4. Result. A total of 106 constituents were identified in XRG-4. Eighty-nine components were identified in biological samples, including 78 in urine (24 prototypes and 54 metabolites), 26 in feces (19 prototypes and 7 metabolites), and 9 in plasma (5 prototypes and 4 metabolites). In other tissues, only a few compounds, including alkaloids and iridoids, were detected. Conclusion. This comprehensive investigation of the chemical and metabolic profiles of XRG-4 provides a scientific foundation for its quality control and administration of clinically-safe medication.

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Impact of curcumin on fatty acid metabolism

Cited by 17 publications

References 92 publications

Curcumae Radix Extract Reduces Beta-Amyloid (Αβ) and Tau Protein Through Increased Mitochondrial Respiration

Curcumae Radix Extract Reduces Beta-Amyloid (Αβ) and Tau Protein Through Increased Mitochondrial Respiration

The Effects of Curcuma Longa on the Osteoarthritis: A Systematic Review of Placebo-Controlled Clinical Studies

Chemicolome and Metabolome Profiling of Xieriga-4 Decoction, A Traditional Mongolian Medicine, Using the UPLC-QTOF/MS Approach

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