Impact of COVID-19 on risks and deaths of non-communicable diseases in the Western Pacific region

Xu, Xiaoyue; Shi, Zumin; Zhou, Lihui; Lin, Jing; Atlantis, Evan; Chen, Xinguang; Hussain, Akhtar; Wang, Youfa; Wang, Yaogang

doi:10.1016/j.lanwpc.2023.100795

Cited by 4 publications

(1 citation statement)

References 67 publications

(134 reference statements)

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“…Third, the COVID-19 pandemic overlapped with our research period from 2020 to 2021 and may have an effect on the all-cause mortality. However, its impact could be considered negligible, as China experienced extremely low life expectancy losses, COVID-19 mortality, and excess mortality [ 37 , 38 ]. Lastly, we focused on a limited range of mortality types.…”

Section: Discussionmentioning

confidence: 99%

The Association of Plasma Homocysteine Concentrations with a 10-Year Risk of All-Cause and Cardiovascular Mortality in a Community-Based Chinese Population

Liang,

Li,

Chen

et al. 2024

Nutrients

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This study is aimed to examine the association of plasma homocysteine (Hcy) concentrations with a 10-year risk of all-cause and cardiovascular (CV) mortality and to explore the modification effect of methylenetetrahydrofolate reductase (MTHFR) C677T genetic polymorphism. This study included 5200 participants from a community-based Chinese population. Cox proportional hazard regression models were used to analyze the associations of Hcy and MTHFR C677T genotype with all-cause and CV mortality. The possible modification effect of the MTHFR C677T genotype on the Hcy–mortality relationship was assessed. The individuals with Hcy concentrations ≥ 10 μmol/L had a significantly higher risk of all-cause mortality compared to those with Hcy < 10 μmol/L (hazard ratio [HR]: 1.72, 95% confidence interval [CI]: 1.11–2.68, p = 0.015). The risk of CV mortality increased by 2% per 1 μmol/L Hcy increment (HR: 1.02, 95% CI: 1.00–1.03, p = 0.036). Despite the MTHFR genotype alone not being correlated with the mortality, the relationship between Hcy and all-cause mortality was significant in the CC genotype compared with CT/TT genotype (p for interaction = 0.036). Elevated plasma Hcy concentrations were associated with an increased 10-year risk of all-cause and CV mortality among the Chinese population. MTHFR C677T genetic polymorphism could modify the association between Hcy and all-cause mortality.

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Section: Discussionmentioning

confidence: 99%