Impact of COVID-19 on pregnant women's health: Consequences in obstetrics two years after the pandemic

Egloff, Charles; Roques, Pierre; Picone, Olivier

doi:10.1016/j.jri.2023.103981

Cited by 4 publications

(5 citation statements)

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“…Previous studies on maternal cytokine levels in pregnant women with SARS-CoV-2 infection have reported conflicting results, possibly due to variations in study design and factors that may influence cytokine levels such as the timing of sample collection and severity of disease ( Egloff et al, 2023 ; Rosen et al, 2022 ; Taglauer et al, 2022 ; Tanacan et al, 2021 ). Studies of cytokine levels in relation to disease severity have reported inconsistent results.…”

Section: Discussionmentioning

confidence: 99%

“…As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has progressed, antenatal infection has been reported to be associated with an array of adverse perinatal outcomes including preterm birth, preeclampsia, intensive care unit (ICU) admission, and maternal death ( Cavalcante et al, 2021 ; Egloff et al, 2023 ; E. R. Smith et al, 2023 ). However, the majority of these findings are in the setting of at least moderate maternal illness ( Brandt et al, 2021 ; Metz et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

“…SARS-CoV-2 infection during pregnancy has been associated with increased levels of interleukin IL-2, IL-6, IL-8, IL-10 and IL-17 after first trimester SARS-CoV-2 infection and interferon (IFN)-γ after third trimester SARS-CoV-2 infection compared to non-infected pregnant women in plasma collected upon admission to the hospital or at delivery, in severe immune activation also referred to as the ‘cytokine storm’ ( Cavalcante et al, 2021 ; Egloff et al, 2023 ; Taglauer et al, 2022 ; Tanacan et al, 2021 ). However, others found no difference in cytokine levels between SARS-CoV-2 infected cases and controls in plasma collected throughout gestation or upon admission to the hospital ( Sherer et al, 2021 ; Trilla et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

SARS-CoV-2 infection, inflammation and birth outcomes in a prospective NYC pregnancy cohort

Gigase,

Jessel,

Kaplowitz

et al. 2024

Journal of Reproductive Immunology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

SARS-CoV-2 infection, inflammation and birth outcomes in a prospective NYC pregnancy cohort

Gigase,

Jessel,

Kaplowitz

et al. 2024

Journal of Reproductive Immunology

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“…In particular, some authors have analyzed and highlighted, with statistically significant results, data relating to the primary cause determining the decision for caesarean section in patients with primary COVID 19 infection. The main cause would be preeclampsia not only for cesarean section but also for medical induced PTB, only secondarily would be fetal compromise and respiratory complications [19,30].…”

Section: Discussionmentioning

confidence: 99%

Covid19 and Pregnancy: Infected Mothers and Premature Babies?

Franco,

Perelli,

Gallitelli

et al. 2024

Preprint

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Introduction: The emergency of the SARS-CoV-2 virus spread and its subsequent global pan-demic have raised significant concerns regarding its impact on pregnancy outcomes. This review aims to summarize the emerging data on the risk of preterm delivery in pregnant women infected with SARS-CoV-2. Materials and Methods: A systematic search was conducted from March 2020 to December 2023 using PubMed, following PRISMA guidelines. Studies correlating maternal COVID-19 infection with preterm birth were included. Results: Thirteen studies were analyzed, indicating a higher incidence of preterm birth in SARS-CoV-2 positive pregnant women compared to controls. The average incidence rate of pre-term birth in infected patients was 18.5%, with a median of 12.75%, while non infected women showed an average incidence of preterm birth of 10% with a median of 8.2%. Discussion: Studies suggest an association between SARS-CoV-2 infection during pregnancy and increased risk of preterm birth and cesarean section. Severity of symptoms and underlying comorbidities further elevate this risk. Notably, infections during the third trimester pose the highest risk of preterm birth. Conclusion: Preventing SARS-CoV-2 infection during pregnancy is crucial to mitigate adverse obstetric outcomes. Close monitoring and tailored interventions for infected pregnant women, particularly those in later trimesters and with comorbidities, are imperative to reduce the risk of preterm birth and improve maternal-fetal outcomes.

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“…Other studies have encountered substantial maternal deaths due to COVID-19 in the Americas, especially in advanced maternal ages [32]. The occurrence of excess maternal deaths during the critical period of March to June 2021 likely also reflects the late and slow adoption of measures to control and mitigate the epidemic's effects in the country [33][34][35], such as vaccination of pregnant and postpartum women [2], associated with a substantial protective effect against SARS-CoV-2 infection, severe cases, and deaths [36][37][38][39].…”

Section: Plos Onementioning

confidence: 99%

Impact of the COVID-19 pandemic on excess maternal deaths in Brazil: A two-year assessment

Orellana,

Leventhal,

Flores-Quispe

et al. 2024

PLoS ONE

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Background Accurate estimates of the COVID-19 pandemic’s indirect impacts are crucial, especially in low- and middle-income countries. This study aims to update estimates of excess maternal deaths in Brazil during the first two years of the COVID-19 pandemic. Methods This was an exploratory mixed ecological study using the counterfactual approach. The observed maternal deaths were gathered from the Mortality Information System (SIM) for the period between March 2015 and February 2022. Expected deaths from March 2020 to February 2022 were estimated using quasipoisson generalized additive models, considering quadrimester, age group, and their interaction as predictor variables. Analyses were performed in R version 4.1.2, RStudio, version 2023.03.1+446 and carried out with support from the “mgcv” and “plot_model” libraries. Results A total of 5,040 maternal deaths were reported, with varying excess mortality across regions and age groups, resulting in 69% excess maternal mortality throughout Brazil during the first two years of the pandemic. The Southeast region had 50% excess mortality throughout the first two years and 76% excess in the second year. The North region had 69% excess mortality, increasing in the second year, particularly among women aged 20–34. The Northeast region showed 80% excess mortality, with a significant increase in the second year, especially among women aged 35–49. The Central-West region had 75% excess mortality, higher in the second year and statistically significant among women aged 35–49. The South region showed 117% excess mortality, reaching 203% in the second year among women aged 20–34, but no excess mortality in the 10–19 age category. Conclusions Over two years, Brazil saw a significant impact on maternal excess deaths, regardless of region and pandemic year. The highest peak occurred between March and June 2021, emphasizing the importance of timely and effective epidemic responses to prevent avoidable deaths and prepare for new crises.

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Impact of COVID-19 on pregnant women's health: Consequences in obstetrics two years after the pandemic

Cited by 4 publications

References 97 publications

SARS-CoV-2 infection, inflammation and birth outcomes in a prospective NYC pregnancy cohort

SARS-CoV-2 infection, inflammation and birth outcomes in a prospective NYC pregnancy cohort

Covid19 and Pregnancy: Infected Mothers and Premature Babies?

Impact of the COVID-19 pandemic on excess maternal deaths in Brazil: A two-year assessment

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