Impact of COVID-19 on Outcomes of Patients Hospitalized With STEMI: A Nationwide Propensity-matched Analysis

Impact of the COVID-19 Pandemic, Stratified by Transfer and COVID-19 Infection Status, on Inpatient Mortality in ST-Elevation Myocardial Infarction Patients, Using a Nationally Representative Database

“…17 As 2020 progressed, overall STEMI mortality decreased, which is why there is no significant difference in overall STEMI mortality in 2020 compared to STEMI mortality between 2016 to 2019. 1 Consistent with our findings, a study by Goel et al also found that concurrent COVID-19 infection increases the odds of inpatient STEMI mortality. 1 Previous studies have demonstrated that COVID-19 infection raises the risk of acute myocardial infarction through various mechanisms, including a cytokine storm, hypercoagulability and endothelial dysfunction.…”

“…1 Consistent with our findings, a study by Goel et al also found that concurrent COVID-19 infection increases the odds of inpatient STEMI mortality. 1 Previous studies have demonstrated that COVID-19 infection raises the risk of acute myocardial infarction through various mechanisms, including a cytokine storm, hypercoagulability and endothelial dysfunction. [18][19][20][21][22][23][24][25] Although the specific factors contributing to inferior inpatient outcomes for STEMI patients with concurrent COVID-19 infection are not yet fully understood, it is speculated that these patients are more susceptible to associated cardiovascular complications and carry a higher thrombus burden .…”

“…[18][19][20][21][22][23][24][25] Although the specific factors contributing to inferior inpatient outcomes for STEMI patients with concurrent COVID-19 infection are not yet fully understood, it is speculated that these patients are more susceptible to associated cardiovascular complications and carry a higher thrombus burden . 1 for use under a CC0 license. This article is a US Government work.…”

“…Previous studies have demonstrated that patients hospitalized for an acute myocardial infarction with concurrent COVID-19 infection experience higher in-hospital mortality rates compared to those without COVID-19. 1,2 During the initial pandemic surge, there was a significant decrease in STEMI admissions, which may be attributed to patients avoiding hospitals due to fear of exposure to COVID-19. [3][4][5] Moreover, door-to-balloon angioplasty time increased at the onset of the pandemic in numerous countries, including the United States (U.S.), as a result of restructured treatment protocols, stringent infection-control policies and overwhelmed emergency departments.…”

Impact of COVID-19 Infection on the Clinical Outcomes of Pulmonary Embolism Hospitalizations : A Nationwide Analysis

“…Patients with concurrent PE and COVID-19 had a > 2 fold risk of mortality compared to patients with PE alone 25 . These findings are similar to the reported higher in-hospital mortality noted in patients admitted with concurrent COVID-19 infection and other cardiovascular co-morbidities and diseases 26 , 27 . This can partly be explained by the fact that patients with concurrent COVID-19 infection and PE were at a higher risk of developing in-hospital complications, in specific septic shock and respiratory failure as noted in this present study.…”