Impact of COVID-19 on Male Fertility

Collins, Alexander B; Zhao, Lei; Zhu, Ziwen; Givens, Nathan T; Bai, Qian; Wakefield, Mark R.; Fang, Yujiang

doi:10.1016/j.urology.2021.12.025

Cited by 14 publications

(16 citation statements)

References 55 publications

(65 reference statements)

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“…Multiple groups have shown the presence of viral RNA in cardiac, renal, and brain tissues 7–10 . There is also some evidence of virus in the male genital tract (MGT) 11, 12 . Furthermore, symptoms associated with all these organ systems have been regularly reported 13 .…”

Section: Introductionmentioning

confidence: 99%

An immunoPET probe to SARS-CoV-2 reveals early infection of the male genital tract in rhesus macaques

Madden

Thomas

Blair

et al. 2022

Preprint

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Because of the recognized systemic nature of SARS-CoV-2 infection, a non-invasive and unbiased method is needed to clarify its spatiotemporal dynamics in vivo after transmission. We recently developed a probe based on the anti-SARS-CoV-2 spike antibody CR3022 to study SARS-CoV-2 pathogenesis in vivo. Herein, we describe its use in immunoPET to investigate SARS-CoV-2 infection of rhesus macaques. Using PET/CT imaging of macaques at different times post-SARS-CoV-2 inoculation, we demonstrate that the 64Cu-labelled CR3022-F(ab′)2 probe targeting the spike protein of SARS-CoV-2 can be used to study the dynamics of infection within the respiratory tract and uncover novel sites of infection. Differences in lung pathology between infection with the WA1 isolate and the delta variant were readily observed using immunoPET and corroborated CT lung pathology. The ability of the probe to illuminate lung-associated pathology demonstrates its specificity and function to detect infection in PET scan. The 64Cu-CR3022-probe also demonstrated dynamic changes occurring between 1- and 2-weeks post-infection. Remarkably, a robust signal was seen in the male genital tract (MGT) of all three animals studied. Infection of the MGT was validated by immunofluorescence imaging of infected cells in the testicular and penile tissue and severe pathology was observed in the testes of one animal at 2-weeks post-infection. The results presented here underscore the utility of using immunoPET to study the dynamics of SARS-CoV-2 infection to understand its pathogenicity and discover new anatomical sites of viral replication. We provide direct evidence for SARS-CoV-2 infection of the MGT in rhesus macaques revealing the possible pathologic outcomes of viral replication at these sites.

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Section: Introductionmentioning

confidence: 99%

An immunoPET probe to SARS-CoV-2 reveals early infection of the male genital tract in rhesus macaques

Madden

Thomas

Blair

et al. 2022

Preprint

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“…The potential reproductive harm of antiviral medications is frequently overlooked during COVID-19 therapy. Some of the most common antiviral drugs are ribavirin, remdesivir, interferon, ivermectin, lopinavir, chloroquine, and ritonavir [ 63 , 164 ]. Ribavirin, an antiviral drug, was found to impair testosterone levels and dysregulated spermatogenesis [ 165 ].…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

“…Because the androgen response element acts as a transcriptional promotor for TMPRSS2, this is likely to be the case. Co-expression of ACE2 and TMPRSS2 is hypothesized to be necessary for viral entrance into cells [ 62 , 63 ].…”

Section: Sars-cov-2 Infection and Male Infertilitymentioning

confidence: 99%

Insights into the Scenario of SARS-CoV-2 Infection in Male Reproductive Toxicity

et al. 2023

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COVID-19 has become a significant public health concern that has catastrophic consequences for society. Some preliminary evidence suggests that the male reproductive system may be an infection target for SARS-CoV-2. SARS-CoV-2 may be transmitted sexually, according to preliminary research. Testicular cells exhibit a high level of the angiotensin-converting enzyme 2 (ACE2) receptor, which enhances the entry of the SARS-CoV-2 into host cells. Some instances of COVID-19 have been documented to exhibit hypogonadism during the acute stage. Furthermore, systemic inflammatory reactions triggered by SARS-CoV-2 infection may cause oxidative stress (OS), which has been shown to have profoundly deleterious consequences on testicular functioning. This work gives a clear picture of how COVID-19 may affect male reproductive systems and calls attention to the many unanswered questions about the mechanisms by which this virus can be linked to men’s health and fertility.

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“…A Infecção pelo Sars-Cov-2 aponta o aumento dos marcadores inflamatórios, sendo o estado inflamatório, considerado semelhante ao estado de baixa tensão de oxigênio, estão associados ao estresse oxidativo e à produção dos radicais livres, o estresse oxidativo pode danificar as células de Leydig, interromper a capacidade de produção da testosterona e causar danos germinativos, dificultando assim, a espermatogênese (Collins et al, 2022).…”

Section: Interferência Do Covid-19 Na Fertilidade Masculinaunclassified

Interferência do Covid-19 na fertilidade masculina

Dias

Fazenda²,

Ramos³

2022

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O presente trabalho objetiva estudar o impacto da infecção pelo Coronavírus na continuidade da vida e na perpetuação das espécies, considerando que a geração de um embrião sadio é de extrema importância, principalmente no presente cenário, em que cada vez mais a taxa natalidade vem sendo reduzida, e aumenta-se a necessidade de uma investigação, pois já existem várias alterações encontradas em estudos recentes que estimam que a Covid-19 poderá gerar complicações mais graves e, com isso, surge a possibilidade de comprometimento da saúde reprodutiva causando ainda mais um descontrole da natalidade. Através de revisão de literatura é constatado no trabalho as interferências e o possível comprometimento da fertilidade considerando que foi desenvolvido a partir de bases confiáveis como, Nature, Pubmed e Scielo, a análise possibilita perceber que alguns dos parâmetros de fertilidade se encontram alterados após paciente infectado. Para o estudo realizado foram utilizadas informações a respeito dos fatores que interferem na fertilidade, utilizando estudos que aplicaram testes In vitro, In vivo, e análise de revisão de literatura que apresentam pesquisas relacionadas à infecção.

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Impact of COVID-19 on Male Fertility

Cited by 14 publications

References 55 publications

An immunoPET probe to SARS-CoV-2 reveals early infection of the male genital tract in rhesus macaques

An immunoPET probe to SARS-CoV-2 reveals early infection of the male genital tract in rhesus macaques

Insights into the Scenario of SARS-CoV-2 Infection in Male Reproductive Toxicity

Interferência do Covid-19 na fertilidade masculina

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