Impact of COVID 19 on erectile function

Adeyemi, Damilare Hakeem; Odetayo, Adeyemi Fatai; Hamed, Moses Agbomhere; Akhigbe, R.E.

doi:10.1080/13685538.2022.2104833

Cited by 27 publications

(17 citation statements)

References 193 publications

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“…The findings that acrylamide impaired the HPT axis are similar to that of Gül et al [ 30 ] and Erdemli et al [ 31 ]. These observed impairment in testicular functions can be ascribed to oxidative stress [ 32 , 33 ], inflammatory response [ 23 , 34 ], and apoptosis [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Zinc ameliorates acrylamide-induced oxidative stress and apoptosis in testicular cells via Nrf2/HO-1/NfkB and Bax/Bcl2 signaling pathway

Ajibare,

Odetayo,

Akintoye

et al. 2024

Redox Report

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Background: Acrylamide is a toxic substance formed in some foods that require high-temperature cooking processes and has been implicated as a gonadotoxic agent. Zinc, on the other hand, is a known antioxidant with fertility-enhancing properties. Hence, this study was designed to explore the possible ameliorative effect of zinc in acrylamide-induced gonadotoxicity. Methods: Twenty-four male Wistar rats were randomized into control, acrylamide (10 mg/kg of acrylamide), acrylamide + 1 mg/kg of zinc, and acrylamide + 3 mg/kg of zinc. The administration was via the oral route and lasted for 56 days. Results: Zinc treatment ameliorated acrylamide-impaired sperm quality, normal testicular histoarchitecture, and hormonal balance, which was accompanied by increased testicular malondialdehyde and interleukin-1β and decreased testicular superoxide dismutase (SOD) and catalase (CAT). Furthermore, zinc prevented acrylamide-induced downregulation of testicular nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and B-cell lymphoma 2 (BCl2) expression and upregulation of testicular nuclear factor kappa B (NF-κB) and bcl-2-like protein 4 (bax) expression. Conclusion: In conclusion, zinc may protect against acrylamide-induced testicular toxicity, mediated by its antioxidant, anti-inflammatory, and antiapoptotic effects.

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Section: Discussionmentioning

confidence: 99%

Zinc ameliorates acrylamide-induced oxidative stress and apoptosis in testicular cells via Nrf2/HO-1/NfkB and Bax/Bcl2 signaling pathway

Ajibare,

Odetayo,

Akintoye

et al. 2024

Redox Report

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“…SARS-CoV-2 infection negatively impacts the HPG axis, affecting male reproductive hormone levels and testicular physiology [64,65]. Endocrine disturbances linked to the male reproductive system decrease testosterone levels in patients with COVID-19, resulting in hypogonadism, which may result in erectile dysfunction (ED) [66,67]. In addition, other hormones, such as LH and FSH levels, were significantly lower, and estradiol levels were higher in COVID-19 patients [68,69].…”

Section: Discussionmentioning

confidence: 99%

A Scientometric Evaluation of COVID-19 and Male Reproductive Research

Panner Selvam,

Kapoor,

Baskaran

et al. 2023

Clinics and Practice

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The COVID-19 pandemic due to the SARS-CoV-2 coronavirus showed acute and prolonged effects on human health. In addition, over the past four years, there has been a tremendous surge in COVID-19-related scientific publications, as shown by bibliometric and scientometric studies. However, such analysis of the scientific literature is lacking in the area of male reproduction. The current scientometric study analyzes publication characteristics of articles related to male reproduction and COVID-19 infection. We used the Scopus database to analyze scientometric data (the number of publications, journals, countries, type of documents, and subject area) related to COVID-19 and male reproductive research. Our literature search identified 345 articles related to COVID-19 and male reproductive research. Most of the articles were published in the USA (n = 72), Italy (n = 55), and China (n = 51). Such research was mainly focused around medicine (57.1%), followed by biochemistry, genetics, and molecular biology (25.7%). Also, in the area of male reproduction, only 37.1% (n = 128) of the articles contributed towards original research, whereas 52.8% (n = 182) were review articles and editorials focusing more on sexual dysfunction than infertility. Such a small number of studies published on COVID-19-related effects on male reproduction warrants a significant increase in research, which is required to decipher the mechanism(s) underlying SARS-CoV-2 infection-associated impairment of male reproductive function.

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“…The HPG axis is key in the regulation of reproductive functions in vertebrates ( 64 , 65 ). While the two main hormones at the anterior pituitary level of the HPG axis, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), stimulate gonadal functions (steroidogenesis and spermatogenesis) ( 68 );, the release of these hormones is mainly regulated by neurons at the hypothalamic level that produces GnRH ( 15 , 69 ). Pulsatile GnRH secretion can be triggered by environmental and tactile cues like food availability, photoperiod, rainfall, and the presence of a mate ( 70 ).…”

Section: Gnihmentioning

confidence: 99%

Impact of stress on male fertility: role of gonadotropin inhibitory hormone

Odetayo,

Akhigbe,

Bassey

et al. 2024

Front. Endocrinol.

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Studies have implicated oxidative stress-sensitive signaling in the pathogenesis of stress-induced male infertility. However, apart from oxidative stress, gonadotropin inhibitory hormone (GnIH) plays a major role. The present study provides a detailed review of the role of GnIH in stress-induced male infertility. Available evidence-based data revealed that GnIH enhances the release of corticosteroids by activating the hypothalamic-pituitary-adrenal axis. GnIH also mediates the inhibition of the conversion of thyroxine (T4) to triiodothyronine (T3) by suppressing the hypothalamic-pituitary-thyroidal axis. In addition, GnIH inhibits gonadotropin-releasing hormone (GnRH), thus suppressing the hypothalamic-pituitary-testicular axis, and by extension testosterone biosynthesis. More so, GnIH inhibits kisspeptin release. These events distort testicular histoarchitecture, impair testicular and adrenal steroidogenesis, lower spermatogenesis, and deteriorate sperm quality and function. In conclusion, GnIH, via multiple mechanisms, plays a key role in stress-induced male infertility. Suppression of GnIH under stressful conditions may thus be a beneficial prophylactic and/or therapeutic strategy.

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Impact of COVID 19 on erectile function

Cited by 27 publications

References 193 publications

Zinc ameliorates acrylamide-induced oxidative stress and apoptosis in testicular cells via Nrf2/HO-1/NfkB and Bax/Bcl2 signaling pathway

Zinc ameliorates acrylamide-induced oxidative stress and apoptosis in testicular cells via Nrf2/HO-1/NfkB and Bax/Bcl2 signaling pathway

A Scientometric Evaluation of COVID-19 and Male Reproductive Research

Impact of stress on male fertility: role of gonadotropin inhibitory hormone

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