Impact of COVID-19 on 2020 transplant activity and waiting lists in France✰,✰✰

Legeai, Camille; Savoye, Émilie; Cantrelle, C.; Jasseron, Carine; Santin, Gaëlle; Brousse, Georges; Duman, Meral Çalış; Foubert, F.; Mahmoudi, Ramzi; Deshayes, A.; Kerbaul, François

doi:10.1016/j.liver.2021.100051

Cited by 3 publications

(13 citation statements)

References 5 publications

(5 reference statements)

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“…A 20%–25% reduction in organ recovery was reported in the first wave of the pandemic, 10 , 14 , 16 , 20 , 21 although regional variation was significant with some areas experiencing reductions of 50%–80%. 9 , 17 , 22 Furthermore, a US report of kidney transplantation found 21% of kidneys accepted for transplantation in 2020 were discarded, corresponding to COVID-19 surges and most frequently relating to the inability to locate an organ recipient.…”

Section: Covid-19 and Organ Donation And Transplant Activitymentioning

confidence: 98%

“…First, reductions in donor referrals of 12%–39% were reported in 2020. 9 , 10 National lockdowns and travel restrictions resulted in a reduction in major trauma and road traffic accidents, 11 , 12 and in some locations, patients were hesitant to seek medical attention for other critical conditions—perhaps relating to fear of burdening already stretched healthcare systems or of contracting SARS-CoV-2 infection themselves. 13 Intensive care units were caring for a different population, evidenced by a 4.5% reduction in donors dying from trauma, 25% reduction in donors dying from road traffic accidents, and 35% increase in donors dying from substance abuse over the first wave of the pandemic.…”

Section: Covid-19 and Organ Donation And Transplant Activitymentioning

confidence: 99%

“… 8 Declines were seen in all organ types; heart transplantation was least impacted with a 5% global reduction in 2020. 8 , 10 , 20 , 21 , 22 , 28 , 29 …”

Section: Covid-19 and Organ Donation And Transplant Activitymentioning

confidence: 99%

“… 7 , 18 , 42 , 43 Others kept lower risk candidates active, such as those not requiring depleting induction therapy, no additional risk factors for severe COVID-19, and higher estimated posttransplant survival scores, who may be anticipated to require shorter hospital stays and be managed out with critical care. 10 , 15 , 18 , 22 , 23 …”

Section: Covid-19 and Organ Donation And Transplant Activitymentioning

confidence: 99%

“…In the United States, registrations fell by up to 50% in the first wave, 22 and in France, reductions of 27% for lung, 15% for kidney, 10% for heart, and 2% for liver transplants were seen in 2020. 10 Furthermore, waitlist suspensions were up to 75% higher than prepandemic levels, with 70% relating to COVID precautions, implying that center-level risks to service delivery or individualized risk assessment decisions at a patient-level necessitated suspensions. 20 , 28 Globally, it is estimated 48 239 waitlisted patient life-years have been lost because of the pandemic.…”

Section: Covid-19 and Organ Donation And Transplant Activitymentioning

confidence: 99%

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The Global Impact of COVID-19 on Solid Organ Transplantation: Two Years Into a Pandemic

et al. 2022

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The coronavirus disease 2019 (COVID-19) pandemic has had a major global impact on solid organ transplantation (SOT). An estimated 16% global reduction in transplant activity occurred over the course of 2020, most markedly impacting kidney transplant and living donor programs, resulting in substantial knock-on effects for waitlisted patients. The increased severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection risk and excess deaths in transplant candidates has resulted in substantial effort to prioritize the safe restart and continuation of transplant programs over the second year of the pandemic, with transplant rates returning towards prepandemic levels. Over the past 2 y, COVID-19 mortality in SOT recipients has fallen from 20%–25% to 8%–10%, attributed to the increased and early availability of SARS-CoV-2 testing, adherence to nonpharmaceutical interventions, development of novel treatments, and vaccination. Despite these positive steps, transplant programs and SOT recipients continue to face challenges. Vaccine efficacy in SOT recipients is substantially lower than the general population and SOT recipients remain at an increased risk of adverse outcomes if they develop COVID-19. SOT recipients and transplant teams need to remain vigilant and ongoing adherence to nonpharmaceutical interventions appears essential. In this review, we summarize the global impact of COVID-19 on transplant activity, donor evaluation, and patient outcomes over the past 2 y, discuss the current strategies aimed at preventing and treating SARS-CoV-2 infection in SOT recipients, and based on lessons learnt from this pandemic, propose steps the transplant community could consider as preparation for future pandemics.

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Section: Covid-19 and Organ Donation And Transplant Activitymentioning

confidence: 98%

Section: Covid-19 and Organ Donation And Transplant Activitymentioning

confidence: 99%

“… 8 Declines were seen in all organ types; heart transplantation was least impacted with a 5% global reduction in 2020. 8 , 10 , 20 , 21 , 22 , 28 , 29 …”

Section: Covid-19 and Organ Donation And Transplant Activitymentioning

confidence: 99%

Section: Covid-19 and Organ Donation And Transplant Activitymentioning

confidence: 99%

Section: Covid-19 and Organ Donation And Transplant Activitymentioning

confidence: 99%

See 3 more Smart Citations

The Global Impact of COVID-19 on Solid Organ Transplantation: Two Years Into a Pandemic

et al. 2022

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Transplantation in the Pandemic Era: Perspectives on the Utilization of COVID-19 Positive Organs

Bhasin,

Byrne,

Alpizar-Rivas

et al. 2024

Transplantation Proceedings

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Transplantation Amid a Pandemic: The Fall and Rise of Kidney Transplantation in the United States

Bisen

Zeiser

Boyarsky

et al. 2022

Transplantation Direct

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Background. Following the outbreak of coronavirus disease 2019 (COVID-19) in the United States, the number of kidney waitlist additions and living-donor and deceased-donor kidney transplants (LDKT/DDKT) decreased substantially but began recovering within a few months. Since then, there have been several additional waves of infection, most notably, the Delta and Omicron surges beginning in August and December 2021, respectively. Methods. Using SRTR data, we compared observed waitlist registrations, waitlist mortality, waitlist removal due to deteriorating condition, LDKT, and DDKT over 5 distinct pandemic periods to expected events based on calculations from preepidemic data while accounting for seasonality and secular trends. Results. Although the number of daily waitlist additions has been increasing since May 2020, the size of the active waitlist has consistently declined, reaching a minimum of 52 556 on February 27, 2022. The recent Omicron surge knocked LDKT from 25% below baseline (incidence rate ratio [IRR] = 0.69 0.75 0.81 ) during the Delta wave to 38% below baseline (IRR = 0.58 0.62 0.67 ). DDKT, however, was less affected by the Omicron wave (IRR = 0.85 0.89 0.93 and 0.88 0.92 0.96 during the Delta and Omicron waves, respectively). Waitlist death decreased from 56% above baseline (IRR = 1.43 1.56 1.70 ) during Delta to 41% above baseline during Omicron, whereas waitlist removal due to deteriorating condition remained at baseline/expected levels during the Delta wave (IRR = 0.93 1.02 1.12 ) and the Omicron wave (IRR = 0.99 1.07 1.16 ). Conclusions. Despite exceptionally high COVID-19 incidence during the Omicron wave, the transplant system responded similarly to prior waves that imposed a lesser disease burden, demonstrating the transplant system’s growing adaptations and resilience to this now endemic disease.

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Impact of COVID-19 on 2020 transplant activity and waiting lists in France✰,✰✰

Cited by 3 publications

References 5 publications

The Global Impact of COVID-19 on Solid Organ Transplantation: Two Years Into a Pandemic

The Global Impact of COVID-19 on Solid Organ Transplantation: Two Years Into a Pandemic

Transplantation in the Pandemic Era: Perspectives on the Utilization of COVID-19 Positive Organs

Transplantation Amid a Pandemic: The Fall and Rise of Kidney Transplantation in the United States

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