Impact of COVID-19 Infection on Patients with Preexisting Interstitial Lung Disease: A Spanish Multicentre Study

Martínez-Besteiro, Elisa; Molina-Molina, María; Gaeta, Anna; Aburto, Myriam; Casanova, Álvaro; Bobillo, Juan Rigual; Orozco, Sandra; Rojo, Ricardo; Godoy, Raúl; Ballesteros, Belén López-Muñiz; Robles, Erwin Javier Pinillos; Fraga, Susana Sánchez; Miguel, Teresa Peña; Balcells, Eva; Laporta, Rosalía; Portal, José Antonio Rodríguez; Lara, Susana Herrera; Cabrera, Eva; Acosta, Orlando; Peláez, Adrián; Valenzuela, Claudia

doi:10.1016/j.arbres.2023.01.001

Cited by 3 publications

(4 citation statements)

References 20 publications

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“…In the current study, this was further confirmed for ILD patients, who presented specific features. Therefore, our results are consistent with other published cohort studies of patients with ILD: these patients have a more severe form of SARS-CoV-2 infection and COVID-19 as well as higher mortality [29].…”

Section: Discussionsupporting

confidence: 93%

Clinical Profile and Determinants of Mortality in Patients with Interstitial Lung Disease Admitted for COVID-19

Mulet

Núñez‐Gil

Carbonell

et al. 2023

JCM

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Background: Concern has risen about the effects of COVID-19 in interstitial lung disease (ILD) patients. The aim of our study was to determine clinical characteristics and prognostic factors of ILD patients admitted for COVID-19. Methods: Ancillary analysis of an international, multicenter COVID-19 registry (HOPE: Health Outcome Predictive Evaluation) was performed. The subgroup of ILD patients was selected and compared with the rest of the cohort. Results: A total of 114 patients with ILDs were evaluated. Mean ± SD age was 72.4 ± 13.6 years, and 65.8% were men. ILD patients were older, had more comorbidities, received more home oxygen therapy and more frequently had respiratory failure upon admission than non-ILD patients (all p < 0.05). In laboratory findings, ILD patients more frequently had elevated LDH, C-reactive protein, and D-dimer levels (all p < 0.05). A multivariate analysis showed that chronic kidney disease and respiratory insufficiency on admission were predictors of ventilatory support, and that older age, kidney disease and elevated LDH were predictors of death. Conclusions: Our data show that ILD patients admitted for COVID-19 are older, have more comorbidities, more frequently require ventilatory support and have higher mortality than those without ILDs. Older age, kidney disease and LDH were independent predictors of mortality in this population.

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Section: Discussionsupporting

confidence: 93%

Clinical Profile and Determinants of Mortality in Patients with Interstitial Lung Disease Admitted for COVID-19

Mulet

Núñez‐Gil

Carbonell

et al. 2023

JCM

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“…There are more than 200 separate disorders that can cause ILDs, including idiopathic pulmonary pneumonia (IIP), connective tissue disease‐associated ILD (CTD‐ILD), sarcoidosis, hypersensitivity pneumonitis (HP), pneumoconiosis, and drug‐induced ILD. Previous studies have shown that idiopathic pulmonary fibrosis (IPF) and fibrosing ILD interstitial lung lesion patients with COVID‐19 pneumonia might have a worse prognosis 5,6 . However, some studies found that IPF, the usual interstitial pneumonia (UIP) pattern, and honeycomb lung were not associated with a severe pattern of COVID‐19 pneumonia 7 …”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have shown that idiopathic pulmonary fibrosis (IPF) and fibrosing ILD interstitial lung lesion patients with COVID-19 pneumonia might have a worse prognosis. 5,6 However, some studies found that IPF, the usual interstitial pneumonia (UIP) pattern, and honeycomb lung were not associated with a severe pattern of COVID-19 pneumonia. 7 Corticosteroids and/or various immunosuppressants (azathioprine, cyclophosphamide [CTX], ciclosporin, mycophenolate, tacrolimus, methotrexate [MTX], etc.)…”

Section: Introductionmentioning

confidence: 99%

Risk factors associated with COVID‐19 pneumonia in Chinese patients with pre‐existing interstitial lung disease during the SARS‐CoV‐2 pandemic

Shao,

Shi,

Chen

et al. 2023

Journal of Medical Virology

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In China, the emergence of a nationally widespread epidemic infection of severe acute respiratory syndrome coronavirus 2 (SARS‐COV‐2) has appeared within a month since December 7, 2022. To evaluate the risk factors for suffering from coronavirus disease 2019 (COVID‐19) pneumonia due to infection with SARS‐CoV‐2 in different kinds of interstitial lung disease (ILD) patients with diverse immunizations, we conducted this retrospective study on 525 patients with ILDs who underwent regular follow‐up in our ILD clinic. Among them, 128 ILD patients (24.4%) suffered from COVID‐19 pneumonia after SARS‐CoV‐2 infection. Patients were older with a male predominance in the pneumonia group than in the nonpneumonia group (65.0 ± 10.0 years vs. 56.4 ± 11.7 years, p < 0.001, 55.5% vs. 39.5%, p = 0.002, respectively). Connective tissue disease‐associated ILD (CTD‐ILD) (25%), idiopathic pulmonary fibrosis (23.4%), and interstitial pneumonia with autoimmune features (21.1%) were the main pre‐existing ILDs in the pneumonia group. In Cox multivariable analysis, only male sex and corticosteroid use were risk factors for COVID‐19 pneumonia after infection. Two or three doses of vaccination were a protective factor for pre‐existing ILD patients suffering from COVID‐19 pneumonia. More than two doses of vaccination were strongly recommended for pre‐existing ILD patients, particularly for males who were administered corticosteroids.

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“…1,2,3,4 Persistent pulmonary damage is associated with disability and therefore may significantly limit the patient's quality of life 5,6,7,8 . On top of that, the recent COVID-19 pandemic learned that patients with pre-existing pulmonary disease have a more severe disease course and higher mortality 9,10 . As a matter of fact, previous tuberculosis (TB) infection is associated with recovery impairment and an increased risk of death after a COVID-19 infection 11 .…”

Section: Introductionmentioning

confidence: 99%

Total Unilateral Collapsed Lung- A Sequela of Pulmonary Tuberculosis- and Pregnancy Outcome

Gopie

2023

MRAJ

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Lung tissue damage after pulmonary tuberculosis is common and can result in persistent pulmonary disability with negative influence on a patient’s quality of life. On the other hand, a COVID-19 infection in a previously treated tuberculosis patient with residual pulmonary abnormalities imposes an increased risk of death. On their own, both of these diseases can have a devastating effect on a patient’s pulmonary system and as such be the cause of disability or even death. In this case report of total atelectasis of the left lung due to obliteration of the left main bronchus after tuberculosis treatment, we present a pregnant patient, who despite a significant reduction in pulmonary function, managed to have a pregnancy with favorable outcome. Thereafter the patient even recovered from a COVID-19 infection, illustrating resilience of the human body.

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Impact of COVID-19 Infection on Patients with Preexisting Interstitial Lung Disease: A Spanish Multicentre Study

Cited by 3 publications

References 20 publications

Clinical Profile and Determinants of Mortality in Patients with Interstitial Lung Disease Admitted for COVID-19

Clinical Profile and Determinants of Mortality in Patients with Interstitial Lung Disease Admitted for COVID-19

Risk factors associated with COVID‐19 pneumonia in Chinese patients with pre‐existing interstitial lung disease during the SARS‐CoV‐2 pandemic

Total Unilateral Collapsed Lung- A Sequela of Pulmonary Tuberculosis- and Pregnancy Outcome

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