Abstract:By analysing the evolution of the COVID‐19 epidemic in the state of Minas Gerais, Brazil, we showed the importance of considering the sub‐notification not only of deaths but also of infected cases. It was shown that the largely used criteria of a historical all‐deaths baseline are not approachable in this case, where most of the deaths are associated with causes that should decrease due to social distancing and reduction of economic activities. A quite simple and intuitive model based on the Gompertz function … Show more
“…The 21.62% underestimation of COVID-19 mortality is very close to the 22% [23] and not far from 28% [25] excess mortality from natural causes and SARI, respectively. Two other studies found an average underreporting of 40.68% (range 25.9-62.7%) for six large metropolitan areas in Brazil [20], and 30-57% in the state of Minas Gerais by mid-June 2020 compared with 2017-2019 mean [22]. The lower bound of these studies was close to the present study mean under-reporting estimate.…”
Section: Discussionsupporting
confidence: 79%
“…To the best of the author's knowledge, this is the first paper on the under-reporting of COVID-19 deaths in Brazil and its federal states for the whole year of 2020 based on comparison of various methods and data sources. Other papers on this topic used the data as of June [20,21], July [22], October [23] and September [24]. Except for the latter, all other used historical time series forecast [19], or 3-year average prior to the epidemic [21], or the last year before the epidemic [22] as a reference to estimate the EM due to COVID-19.…”
Section: Discussionmentioning
confidence: 99%
“…Other papers on this topic used the data as of June [20,21], July [22], October [23] and September [24]. Except for the latter, all other used historical time series forecast [19], or 3-year average prior to the epidemic [21], or the last year before the epidemic [22] as a reference to estimate the EM due to COVID-19. Only two publications provided results for all federal states, as well as for the whole country [23,25] but did not compare the results by multiple methods and data sources.…”
Objective
To evaluate the magnitude of under‐reporting the number of deaths due to COVID‐19 in Brazil in 2020, previously shown to occur due to low rate of laboratory testing for SARS‐CoV‐2, reporting delay, inadequate access to medical care, and its poor quality, leading to the low sensitivity of epidemiological surveillance and poor outcomes, often without laboratory confirmation of the cause of death.
Methods
Excess mortality due to COVID‐19 was estimated directly based on various data sources, and indirectly, based on the difference between the observed and expected number of deaths from serious acute respiratory infection (SARI) and all‐natural causes in 2020 had there been no COVID‐19. The absence of laboratory testing for SARS‐CoV‐2 was adjusted based on the proportion of those who tested positive among the tested individuals whose death was attributed to COVID‐19. Least absolute shrinkage and selection operator (lasso) were used to improve prediction of likely mortality without COVID‐19 in 2020.
Results
Under‐reporting of COVID‐19 deaths was 22.62%, with a corresponding mortality rate per 100 000 inhabitants of 115 by the direct method, 71–76 by the indirect methods based on the excess SARI mortality and 95–104 by excess mortality due to natural causes. COVID‐19 was the third cause of mortality that contributed directly with 18%, and indirectly with additional 10–11% to all deaths in Brazil in 2020.
Conclusions
Underestimation of COVID‐19 mortality between 1:5 and 1:4 is likely its lower bound. Timely and accurate surveillance of death causes is of the essence to evaluate the COVID‐19 burden.
“…The 21.62% underestimation of COVID-19 mortality is very close to the 22% [23] and not far from 28% [25] excess mortality from natural causes and SARI, respectively. Two other studies found an average underreporting of 40.68% (range 25.9-62.7%) for six large metropolitan areas in Brazil [20], and 30-57% in the state of Minas Gerais by mid-June 2020 compared with 2017-2019 mean [22]. The lower bound of these studies was close to the present study mean under-reporting estimate.…”
Section: Discussionsupporting
confidence: 79%
“…To the best of the author's knowledge, this is the first paper on the under-reporting of COVID-19 deaths in Brazil and its federal states for the whole year of 2020 based on comparison of various methods and data sources. Other papers on this topic used the data as of June [20,21], July [22], October [23] and September [24]. Except for the latter, all other used historical time series forecast [19], or 3-year average prior to the epidemic [21], or the last year before the epidemic [22] as a reference to estimate the EM due to COVID-19.…”
Section: Discussionmentioning
confidence: 99%
“…Other papers on this topic used the data as of June [20,21], July [22], October [23] and September [24]. Except for the latter, all other used historical time series forecast [19], or 3-year average prior to the epidemic [21], or the last year before the epidemic [22] as a reference to estimate the EM due to COVID-19. Only two publications provided results for all federal states, as well as for the whole country [23,25] but did not compare the results by multiple methods and data sources.…”
Objective
To evaluate the magnitude of under‐reporting the number of deaths due to COVID‐19 in Brazil in 2020, previously shown to occur due to low rate of laboratory testing for SARS‐CoV‐2, reporting delay, inadequate access to medical care, and its poor quality, leading to the low sensitivity of epidemiological surveillance and poor outcomes, often without laboratory confirmation of the cause of death.
Methods
Excess mortality due to COVID‐19 was estimated directly based on various data sources, and indirectly, based on the difference between the observed and expected number of deaths from serious acute respiratory infection (SARI) and all‐natural causes in 2020 had there been no COVID‐19. The absence of laboratory testing for SARS‐CoV‐2 was adjusted based on the proportion of those who tested positive among the tested individuals whose death was attributed to COVID‐19. Least absolute shrinkage and selection operator (lasso) were used to improve prediction of likely mortality without COVID‐19 in 2020.
Results
Under‐reporting of COVID‐19 deaths was 22.62%, with a corresponding mortality rate per 100 000 inhabitants of 115 by the direct method, 71–76 by the indirect methods based on the excess SARI mortality and 95–104 by excess mortality due to natural causes. COVID‐19 was the third cause of mortality that contributed directly with 18%, and indirectly with additional 10–11% to all deaths in Brazil in 2020.
Conclusions
Underestimation of COVID‐19 mortality between 1:5 and 1:4 is likely its lower bound. Timely and accurate surveillance of death causes is of the essence to evaluate the COVID‐19 burden.
“…However, the epidemiological curves in the country conceal different patterns for notifying the disease in the different administrative units 32 . In Minas Gerais, the curve of COVID-19 infection cases was increased at the end of April 2020 33 . In fact, it was during this month that all macro-regions of the state presented the highest isolation rate between March and November 2020 (above 40%) 34 .…”
Objective: to identify spatial clusters corresponding to abandonment of routine vaccines in children. Method: an ecological study, according to data from the 853 municipalities of a Brazilian state. The records analyzed were those of the multidose pentavalent, pneumococcal 10-valent, inactivated poliomyelitis and oral human rotavirus vaccines of 781,489 children aged less than one year old. The spatial scan statistics was used to identify spatial clusters and assess the relative risk based on the vaccination abandonment indicator. Results: the spatial scan statistics detected the presence of statistically significant clusters for abandonment regarding the four vaccines in all the years analyzed. However, the highest number of clusters with high relative risk estimates was identified in 2020. The Vale do Aço and West, North and West, and Southwest regions stand out for the pentavalent, poliomyelitis and rotavirus vaccines, respectively. Conclusion: in an attempt to mitigate the devastating impact of the COVID-19 pandemic, the immunization program experienced setbacks. The presence of clusters points to the need to implement integrated strategies that may involve different sectors for an active search for children and prevent outbreaks of vaccine-preventable diseases in the near future.
“…Studies of geographic distribution are commonly used in epidemiological studies and represents an important visual tool to understand the density of a disease, or, in the case of this study, the demographic location of the highest concentration of tests requested in each city 14 . The use of these supplementary indicators to monitoring the spread of the disease is crucial for decision-making regarding the protocols to be followed, besides collaborating to appropriate management of patients in the hospitals and health units 13,15,16 .…”
Introduction: With the arrival of the SARS-CoV-2 (Coronavirus 2 of severe acute respiratory syndrome) pandemic in Brazil, especially in the city of São Paulo, there was a need to apply social isolation policies associated with testing, covering all municipalities. The Clinical Analysis Laboratory of Centro Universitário FMABC was one of the first laboratories to receive certification and qualification to perform RT-PCR (reverse transcriptase reaction followed by polymerase chain reaction) tests in the metropolitan region of São Paulo.
Objective: Aim to analyze the influence of adopting social isolation on the incidence of positivity in COVID-19 tests in the metropolitan region of São Paulo, Brazil.
Methods: a descriptive study carried out from March to May 2020, epidemiological data were collected from each unit served and organized by the data controllership team of the Clinical Analysis Laboratory of FMABC. Epidemiological, demographic, and laboratory data were extracted from the Matrix® outpatient data management system. Clinically suspected cases and confirmed by laboratory tests (RT-PCR and serological tests) were entered. The tests were divided into serological tests using the RT-PCR molecular test, on samples of nasopharyngeal mucosal scrapings collected with sterile Swab.
Results: It were evaluated PCR test and antibody presence (IgA, IgM and IgG) in blood samples of 16.297 patients. 22.718 tests were performed for the diagnosis of COVID-19, both RT-PCR (10.410 tests) and serological tests to detect anti-SARS-CoV-2 antibodies, IgA, IgM and IgG, a total of 16.297 patients were assessed, 63% women and 37% men. It was observed that the social isolation policies adopted during this period contained the massive expansion of contamination, at least while the social isolation rates were above 55%.
Conclusion: The data of this study demonstrated the effectiveness of social isolation in containing the positive contamination of SARS-CoV-2 in the metropolitan region of São Paulo, at least for the first three months.
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