On 19 March 2020, California put in place Stay-At-Home orders to reduce the spread of SARS-CoV-2. As a result, decreases up to 50% in traffic occurred across the South Coast Air Basin (SoCAB). We report that, compared to the 19 March to 30 June period of the last 5 years, the 2020 concentrations of PM 2.5 and NO x showed an overall reduction across the basin. O 3 concentrations decreased in the western part of the basin and generally increased in the downwind areas. The NO x decline in 2020 (approximately 27% basin-wide) is in addition to ongoing declines over the last two decades (on average 4% less than the −6.8% per year afternoon NO 2 concentration decrease) and provides insight into how air quality may respond over the next few years of continued vehicular reductions. The modest changes in O 3 suggests additional mitigation will be necessary to comply with air quality standards. Plain Language Summary On 19 March 2020, California put in place Stay-At-Home orders to reduce the spread of SARS-CoV-2. As a result, there was much less traffic in Southern California. Reduced traffic along with a month-long stretch of unusually rainy weather at the beginning of the lockdown led to significant reductions in PM 2.5 and NO x levels across the basin. Concentrations of O 3 , on the other hand, showed inconsistent changes across the basin. The response of O 3 to these large changes in nitrogen oxide concentrations suggests mitigation efforts beyond those associated with continuing vehicle emission reductions will be important to meet clean air goals.