Impact of Continuous Positive Airway Pressure Therapy on Atrial Electromechanical Delay and P‐Wave Dispersion in Patients with Obstructive Sleep Apnea

Abstract

Our findings suggested that CPAP therapy provides more homogenous conduction through atria in patients with OSA. This effect may translate into decreased risk for AF associated with OSA.

Impact of Continuous Positive Airway Pressure Therapy on Atrial Electromechanical Delay in Obesity‐Hypoventilation Syndrome Patients

“…The impact of CPAP therapy on atrial electromechanical delay and P‐wave dispersion was previously studied in OSAS identifying a relation with the severity of the disease and the level of hypoxia . Bayir et al . showed that increased inter‐ and intra‐atrial electromechanical delays and prolonged Pmax and PD are evident in OSAS patients, and improvement in these AF risk markers as well as in diastolic LV function could be obtained after effective CPAP therapy.…”

“…in a study comparing tissue Doppler echocardiography and electrophysiological study found a moderate correlation between intra‐left atrial conduction time detected by tissue Doppler echocardiography (ILCT‐echo) and by electrophysiological study (ILCT‐eps), and demonstrated that tissue Doppler echocardiography was a reliable technique for the measurement of atrial electromechanical delay. Previous studies have demonstrated that prolonged intra‐ and inter‐atrial conduction times and inhomogeneous propagation of sinus impulses would be the characteristics of increased AF risk in various clinical conditions during sinus rhythm . It has been studied in some clinical conditions, and it was found that AEMD is significantly correlated with the prolonged maximum P‐wave duration, P‐wave dispersion, and degree of histopathological changes .…”

“…These effects of CPAP therapy have been shown to result in a decrease in LA volume and LA volume index and in improvement of both the systolic and diastolic left ventricular functions in OSAS patients. The impact of CPAP therapy on atrial electromechanical delay and P‐wave dispersion was previously studied in OSAS identifying a relation with the severity of the disease and the level of hypoxia . Bayir et al .…”

The effect of nasal septum deviation on subclinical cardiac autonomic dysfunction

“…24 Studies have shown that the high rate of AF in OSAS patients indicates the co-occurrence of these two conditions. [24][25][26][27] However, the exact mechanism of AF predisposition in OSAS patients remains unknown. Prolonged intra-and inter-atrial conduction times and inhomogeneous propagation of sinus impulses are common electrophysiological features in AF cases.…”

Atrial arrhythmogenesis in obstructive sleep apnea: Therapeutic implications

“…Both systolic and diastolic abnormalities in patients with OSA can be reversed as early as after three months of CPAP therapy, with progressive improvement in cardiovascular remodeling over one year [76]. Additionally, CPAP therapy provided more homogenous conduction through atria in patients with OSA [77].…”