Impact of continuous positive airway pressure ventilation on cardiovascular outcomes among patients with obstructive sleep apnea: A meta-analysis of randomized trials

Elbadawi, Ayman; Elgendy, Islam Y.; Shnoda, Mina; Abu‐Zaid, Ahmed; Barssoum, Kirolos; Gouda, M.; Megaly, Michael; Bansal, Anju; Gulati, Martha; Jneid, Hani

doi:10.1016/j.ahjo.2021.100056

Cited by 4 publications

(10 citation statements)

References 25 publications

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“…A recent subgroup meta-analysis identified a 36% reduction in major adverse cardiac effects for those utilising CPAP more than four hours per night, consistent with a doseresponse effect of CPAP therapy. 38…”

Section: Cardiovascular Diseasementioning

confidence: 99%

Don't let sleeping men lie

Peel

Wittert

2022

Trends Urol & Men's Health

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The prevalence and severity of obstructive sleep apnoea (OSA) parallels that of obesity and increases with age – affecting over half of men aged 40 years and older in some studies. Nocturia is strongly associated with OSA, as is erectile dysfunction, decrease in libido, type 2 diabetes, cardiovascular disease, depression and malignancy. This article presents an overview of OSA and the effects of the disorder in men.

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Section: Cardiovascular Diseasementioning

confidence: 99%

Don't let sleeping men lie

Peel

Wittert

2022

Trends Urol & Men's Health

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“…Obstructive sleep apnea (OSA) is the most prevalent disorder related to sleep, which is linked to the recurrent collapse of the upper airway during sleeping [ 1 ]. OSA affects between 3% and 4% of the general population [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…According to estimates, the syndrome affects 15% of women and 10% of males [ 3 ]. It also affects between 40% and 60% of people with cardiovascular disease [ 1 ]. It has been identified as one of the most common risk factors for resistant hypertension [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…According to one study, OSA is a significant, recognisable cause of hypertension. CPAP is a well-known OSA treatment that reduces hypoxemic episodes and eases symptoms [ 1 ]. Observational studies in diverse subgroups of CAD patients have demonstrated an elevated risk of recurrent cardiovascular events and OSA.…”

Section: Introductionmentioning

confidence: 99%

“…Although using CPAP therapy for OSA patients is related to better blood pressure and glycaemic management, CPAP's impact on cardiovascular events in OSA patients remains controversial. Even while some randomised studies indicated no advantage for CPAP in lowering cardiovascular outcomes, previous meta-analyses suggested that poor CPAP adherence may be to blame for the lack of good consequences [ 1 ]. However, due to the high prevalence of cardiovascular issues in people with OSA, other specialists advise the long-term usage of CPAP treatment for all patients with sleep-disordered breathing, regardless of daytime symptoms [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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From Snoring to Soaring: Unveiling the Positive Effects of Continuous Positive Airway Pressure Ventilation on Cardiovascular Health in Patients With Obstructive Sleep Apnoea Through a Systematic Review

Swami,

Aye,

Trivedi

et al. 2023

Cureus

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Increased cardiovascular (CV) morbidity and death are linked to obstructive sleep apnoea (OSA). The primary method of treating OSA is continuous positive airway pressure (CPAP). CPAP has some debatable outcomes on CV events in people suffering from OSA. The current study investigates how CPAP affects CV outcomes. The goal is to evaluate CPAP's effectiveness in lowering CV outcomes in OSA patients. We used a computer to search the PubMed, PubMed Central Library, Science Direct, and Google Scholar databases for studies comparing the effects of CPAP and a control group on CV outcomes in OSA patients. These included randomised control trials (RCT), narrative reviews, systematic reviews, case-control studies, observational studies and meta-analyses. A total of 52,937 patients were included in the final analysis of six RCTs, four observational studies, 10 meta-analyses, one case-control study, two systematic reviews and one narrative review. The weighted mean follow-up lasted for a period of between three months and nine years. The risk of major cardiovascular adverse events (MACE) was the same for both the CPAP and control groups. According to subgroup analysis, patients with lower MACE adherence rates (four hours per night) were more likely to use CPAP. The risk of all-cause mortality, CV-related complications causing mortality, acute myocardial infarction acute stroke, or hospitalisations for angina was the same in the CPAP and control groups. The primary outcome was that in patients with therapy with CPAP in addition to usual care and usual care alone did not prevent CV events in patients with moderate-to-severe OSA and existing CV illness. Patients with OSA who utilise CPAP may not experience fewer CV events. Patients who use CPAP consistently (four hours per night) could benefit from improved CV results. Future research must assess how well-adherent patients with severe OSA and low CV event rates respond to CPAP therapy. In patients who use CPAP for more than four hours each night, CPAP therapy may minimise the risk of MACE and stroke. Additional randomised trials requiring adequate CPAP time adherence are needed to support this perception. Despite the fact that there is no evidence to support the claim that CPAP therapy improves CV outcomes, bias difficulties, CPAP adherence problems, and the patient groups included in each RCT may have made it more difficult to generalise the findings to all patients. Future research is therefore needed to look at these relevant results.

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Hypoxic Burden Based on Automatically Identified Desaturations Is Associated with Adverse Health Outcomes

Esmaeili

Labarca

et al. 2023

Annals ATS

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Impact of continuous positive airway pressure ventilation on cardiovascular outcomes among patients with obstructive sleep apnea: A meta-analysis of randomized trials

Cited by 4 publications

References 25 publications

Don't let sleeping men lie

Don't let sleeping men lie

From Snoring to Soaring: Unveiling the Positive Effects of Continuous Positive Airway Pressure Ventilation on Cardiovascular Health in Patients With Obstructive Sleep Apnoea Through a Systematic Review

Hypoxic Burden Based on Automatically Identified Desaturations Is Associated with Adverse Health Outcomes

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