Impact of Conjugation of the Reactive Oxygen Species (ROS)-Generating Catalytic Moiety with Membrane-Active Antimicrobial Peptoids: Promoting Multitarget Mechanism and Enhancing Selectivity
Dasom Song,
Byeongkwon Kim,
Minsang Kim
et al.
Abstract:Antimicrobial peptides (AMPs) represent promising therapeutic modalities against multidrug-resistant bacterial infections. As a mimic of natural AMPs, peptidomimetic oligomers like peptoids (i.e., oligo-N-substituted glycines) have been utilized for antimicrobials with resistance against proteolytic degradation. Here, we explore the conjugation of catalytic metal-binding motifs�the amino terminal Cu(II) and Ni(II) binding (ATCUN) motif�with cationic amphipathic antimicrobial peptoids to enhance their efficacy.… Show more
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