Impact of COMT haplotypes on functional connectivity density and its association with the gene expression of dopamine receptors

DyNAMiC: A prospective longitudinal study of dopamine and brain connectomes: A new window into cognitive aging

“…As such, age‐related DA decline might constitute a basis for changes in the functional connectome. Effects of DA on FC within large‐scale brain networks are, however, reported as diverse (Cole et al, 2013; Wallace et al, 2011), although previous studies indicate regional variability in the association between DA and FC (Tang et al, 2019; Xu et al, 2016), and that the spatial distribution of neurotransmitter receptors contribute to the brain’s functional architecture (Dukart et al, 2021; Hansen et al, 2021). This may have important implications for the functional connectome in aging, as indicated by a recent study showing that regional variability in age‐related effects on FC was related to D1DR (Garzón et al, 2021).…”

Predictor of academic performance: personality traits and catechol-O-methyltransferase polymorphisms

“…It is intriguing to understand how genes affect cognitive processes mediated by the prefrontal cortex (PFC). The catechol-O-methyltransferase gene (COMT) encodes catechol-O-methyltransferase enzyme (COMT), a methylation enzyme involved in the degradation of catecholamines in the prefrontal cortex, including dopamine, epinephrine, and norepinephrine [13]. COMT is abundantly expressed inside the human brain and is responsible for most of the dopamine degradation in PFC.…”

Interaction of Catechol‐O‐methyltransferase Val158Met polymorphism and sex influences association of parietal intrinsic functional connectivity and immediate verbal memory

“…Resting‐state functional magnetic resonance imaging (fMRI) is a very useful method to evaluate interactions between intrinsic brain regions when participants are at rest (Raichle, 2011) and reflect the human brain's functional architecture during cognition as well ( Smith, Fox, & Miller, 2009). Resting‐state fMRI (RS‐fMRI) studies have identified the effect of COMT and COMT × sex interaction on several functional resting‐state networks (RSNs) such as default mode network (DMN), executive control network (ECN), and fronto‐parietal network (FPN) that are highly associated with cognitive functioning (Elton, Smith, Parrish, & Boettiger, 2017; Liu, Song, & Li, 2010; Tang, Li, & Xu, 2019; Tian, Qin, & Liu, 2013; Tunbridge, Farrell, Harrison, & Mackay, 2013). Several behavioral and task‐fMRI studies also provide supporting evidence to demonstrate the relationship between COMT and memory performance (Bertolino, Rubino, & Sambataro, 2006; Egan, Goldberg, & Kolachana, 2001; Frias et al., 2004; Raz, Dahle, Rodrigue, Kennedy, & Land, 2011), as well as COMT × sex interaction effect on cognitive performance (Holtzer et al., 2010; Kempton et al., 2009; O’Hara et al., 2006).…”