Impact of comorbid conditions on asthmatic adults and children

Kaplan, Alan; Szefler, Stanley J.; Halpin, David

doi:10.1038/s41533-020-00194-9

Cited by 49 publications

(49 citation statements)

References 105 publications

(190 reference statements)

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“…The presence of asthma might increase the risk of certain comorbidities [ 9 , 10 ] that may worsen asthma symptoms and provoke acute flare-ups, especially if they are not treated appropriately [ 10 – 13 ]. Thus, the GINA guidelines recommend assessing comorbidities before treatment modification if asthma control worsens [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…Obesity is an important and thoroughly studied risk factor for asthma and a plethora of other diseases, such as hypertension, DM, and IHD among others [ 10 , 22 ]. A very high proportion of our patient population was overweight (70%), even compared with the general Hungarian population, which is in the top 10 most obese countries in Europe [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

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Epidemiology of comorbidities and their association with asthma control

Tomisa

Horváth

Santa³

et al. 2021

Allergy Asthma Clin Immunol

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Background The prevalence of comorbidities and their relation to asthma control and treatment is a topic of increasing interest, however comprehensive studies are scarce. We aimed to determine the prevalence of the most common comorbidities in asthma in relation to patient characteristics (age, gender and body mass index [BMI]) and their association with asthma control in a large, specialist-managed representative patient population. Methods A secondary, exploratory analysis of the Asthma Reality (ARL), across-sectional, non-interventional real-life study was conducted. Basic patient characteristics, the prevalence of comorbidities and data on asthma control and risk factors had been collected and their interactions examined. Descriptive statistics and binomial regression were used to assess the distribution of the prevalence of comorbidities and propensity matching was applied to assess their effect on asthma control. Results Overall, 12,743 patients were enrolled in our study in 187 treatment centres covering all regions of Hungary. Most comorbidities showed significantly different distribution for all basic patient characteristics. Gender, age group, smoking status, BMI and the duration of asthma had a significant impact on asthma control. The frequency of uncontrolled asthma was higher in females (37.1%), in the age group of 46–65 years (39.6%), in severely obese patients (43.2%), in patients who had been diagnosed with asthma for more than 20 years (40.4%), and in active heavy smokers (55%), compared with respective groups in the same category. Based on the binomial regression with propensity score matching, concomitant chronic obstructive pulmonary disease (COPD) (odds ratio [OR] = 2.06, 95% confidence interval [CI] 1.80–2.36), ischaemic heart disease (OR = 1.86, 95% CI 1.64–2.10) and cerebrovascular events (OR = 1.85, 95% CI 1.47–2.32) had the strongest negative effect on asthma control, with the presence of all of these conditions increasing the risk of uncontrolled asthma. Conclusions This evaluation of comorbidity data of more than 12,000, adult asthmatic patients has provided a clearer picture of diseases that can frequently co-exist with asthma, and their influence on asthma control, assessed by the prevalence of symptoms. Our study suggests that most asthmatic patients have at least one comorbidity, and the presence of comorbidities may have a high impact on asthma control measures.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Epidemiology of comorbidities and their association with asthma control

Tomisa

Horváth

Santa³

et al. 2021

Allergy Asthma Clin Immunol

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“…It can complicate the diagnosis and the management of asthma. The symptom of co-morbid conditions may be similar to those associated with poor asthma control which can lead to misdiagnosis and under treatment or over treatment [39].…”

Section: Asthma Self-care Pracɵcementioning

confidence: 99%

Self-care practice and associated factors among adult asthmatic patients on follow-up care at Northwest Amhara referral hospitals, Northwest Ethiopia 2020

2021

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Background Self-care practice of asthma is the strategy for asthma symptom control and future reduction of exacerbation, but it is poorly implemented in clinical settings due to the patients, professionals, and organizational related factors. Therefore, the study aimed to assess the self-care practice and associated factors among adult asthmatic patients at Northwest Amhara referral hospitals. Methods Institution-based cross-sectional study was conducted among asthmatic patients on follow-up care at Northwest Amhara Regional State referral hospitals from February 1st, 2020 to March 30, 2020. Data were collected through an interviewer-administered technique. Asthma self-care practice tool was used to measure the outcome. Data were entered into EPI info version 7 and exported to SPSS version 22 for analysis. A binary logistic regression analysis was used. In multivariable logistic regression analysis, those independent variables having p value < 0.05 were considered as statistically significant with poor self-care practice of asthma. Results A total of 470 participants enrolled in the study with a response rate of 100%. The proportion of good self-care practice among asthmatic patients was found to be 42.3%. The study revealed that; age group ≥ 55 years, having a co-morbid illness and borderline anxiety, having no social support, and drinking alcohol were significantly associated with poor asthma self-care practice. Conclusions Poor-self care practice in this study was high. Efforts need to be implemented for asthmatic patients with older age, having co-morbid illness and borderline anxiety, having no social support, and drinking alcohol.

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“…Asthma mortality data reported that the Netherlands and South Africa had the highest asthma mortality rate globally [26]. Adult-onset asthma may increase the risk of comorbid conditions such as dyspepsia, fluid and electrolyte disorders, chronic obstructive pulmonary disease (COPD), hypertension, congestive heart failure, and diabetes [30].…”

Section: Introductionmentioning

confidence: 99%

Supplements for Smoking-Related Lung Diseases

Alsharairi¹

2021

Encyclopedia

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Supplements for smoking-related lung diseases are considered as nonfood products and thought to improve health. Multivitamins and antioxidants are the most commonly dietary supplements used by cancer and asthma patients. There are currently no clear regulatory guidelines that include dietary supplements and their effect on lung cancer and asthma patients, particularly in smokers. Several countries have taken steps to overcome challenges in regulating dietary supplements in the marketplace. These challenges include inadequate assurance of safety/efficacy, inaccuracy of product labeling, misleading health claims, and lack of analytical techniques for dietary supplements. There is a need to establish standards and regulation of dietary supplement use in patients with lung cancer and asthma. The aim of this entry is to expand knowledge on dietary supplements use and smoking-related lung diseases (lung cancer and asthma).

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Impact of comorbid conditions on asthmatic adults and children

Cited by 49 publications

References 105 publications

Epidemiology of comorbidities and their association with asthma control

Epidemiology of comorbidities and their association with asthma control

Self-care practice and associated factors among adult asthmatic patients on follow-up care at Northwest Amhara referral hospitals, Northwest Ethiopia 2020

Supplements for Smoking-Related Lung Diseases

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