Impact of Collagen Crosslinking on Corneal Sensitivity in Keratoconus Patients

Wasilewski, Daniel; Mello, Glauco H.R.; Moreira, Hamílton

doi:10.1097/ico.0b013e31827978c8

Cited by 33 publications

(26 citation statements)

References 20 publications

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“…Following CXL, corneal sensitivity has been shown to significantly decrease and gradually recover during the first 6 postoperative months [185,186]. No effect on tear secretion or tear film stability was observed [186].…”

Section: Safetymentioning

confidence: 99%

Corneal Collagen Crosslinking: A Systematic Review

Sorkin

Varssano²

2014

Ophthalmologica

152

102

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Keratoconus (KCN) is an ectatic disorder with progressive corneal thinning and a clinical picture of corneal protrusion, progressive irregular astigmatism, corneal fibrosis and visual deterioration. Other ectatic corneal disorders include: post-LASIK ectasia (PLE) and pellucid marginal degeneration (PMD). Corneal crosslinking (CXL) is a procedure whereby riboflavin sensitization with ultraviolet A radiation induces stromal crosslinks. This alters corneal biomechanics, causing an increase in corneal stiffness. In recent years, CXL has been an established treatment for the arrest of KCN, PLE and PMD progression. CXL has also been shown to be effective in the treatment of corneal infections, chemical burns, bullous keratopathy and other forms of corneal edema. This is a current review of CXL - its biomechanical principles, the evolution of CXL protocols in the past, present and future, indications for treatment, treatment efficacy and safety.

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Section: Safetymentioning

confidence: 99%

Corneal Collagen Crosslinking: A Systematic Review

Sorkin

Varssano²

2014

Ophthalmologica

152

102

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“…Two recent studies reported transient hypoesthesia in keratoconic corneas 6 to 9 months after epi-off CXL. 14,15 To our knowledge, to date there have been no published studies of corneal sensitivity after epi-on CXL. This study evaluated corneal sensitivity in keratoconic eyes following epion and epi-off CXL.…”

Section: Resultsmentioning

confidence: 96%

Recovery of corneal sensitivity after collagen crosslinking with and without epithelial debridement in eyes with keratoconus

Spadea

Salvatore

Paroli

2015

Journal of Cataract and Refractive Surgery

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“…The study detected prominent hypoesthesia 1 month after surgery, which gradually recovered by 9 months after surgery; the time course was similar for both sensitivity restoration and corneal nerve regeneration. Another study (22) evaluated the changes in corneal tactile sensitivity following corneal collagen cross-linking in patients with progressive keratoconus and concluded that corneal CXL performed in keratoconus patients induced a considerable decrease in corneal sensitivity. This decrease was greater in the first week after the procedure, with progressive recovery for up to 6 months of follow-up.…”

Section: Discussionmentioning

confidence: 99%