Impact of Coffee Consumption on Cardiovascular Health

Mendoza, Michael F.; Sulague, Ralf Martz; Posas-Mendoza, Therese; Lavie, Carl J.

doi:10.31486/toj.22.0073

Cited by 10 publications

(2 citation statements)

References 43 publications

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“…In addition, our study also presents new perspectives on the use of A 2A R modulators to counteract the cardiovascular risk of LDL-C excess. In fact, caffeine, which induces A 2A R overexpression [ 76 ], has been shown to protect against mortality in cardiovascular disease [ 77 ] and counteract the cardiovascular deleterious effects associated with HC [ 78 ].…”

Section: Discussionmentioning

confidence: 99%

Low Density Lipoprotein Cholesterol Decreases the Expression of Adenosine A2A Receptor and Lipid Rafts-Protein Flotillin-1: Insights on Cardiovascular Risk of Hypercholesterolemia

Chaptal,

Maraninchi,

Musto

et al. 2024

Cells

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High blood levels of low-density lipoprotein (LDL)-cholesterol (LDL-C) are associated with atherosclerosis, mainly by promoting foam cell accumulation in vessels. As cholesterol is an essential component of cell plasma membranes and a regulator of several signaling pathways, LDL-C excess may have wider cardiovascular toxicity. We examined, in untreated hypercholesterolemia (HC) patients, selected regardless of the cause of LDL-C accumulation, and in healthy participants (HP), the expression of the adenosine A2A receptor (A2AR), an anti-inflammatory and vasodilatory protein with cholesterol-dependent modulation, and Flotillin-1, protein marker of cholesterol-enriched plasma membrane domains. Blood cardiovascular risk and inflammatory biomarkers were measured. A2AR and Flotillin-1 expression in peripheral blood mononuclear cells (PBMC) was lower in patients compared to HP and negatively correlated to LDL-C blood levels. No other differences were observed between the two groups apart from transferrin and ferritin concentrations. A2AR and Flotillin-1 proteins levels were positively correlated in the whole study population. Incubation of HP PBMCs with LDL-C caused a similar reduction in A2AR and Flotillin-1 expression. We suggest that LDL-C affects A2AR expression by impacting cholesterol-enriched membrane microdomains. Our results provide new insights into the molecular mechanisms underlying cholesterol toxicity, and may have important clinical implication for assessment and treatment of cardiovascular risk in HC.

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Section: Discussionmentioning

confidence: 99%

Low Density Lipoprotein Cholesterol Decreases the Expression of Adenosine A2A Receptor and Lipid Rafts-Protein Flotillin-1: Insights on Cardiovascular Risk of Hypercholesterolemia

Chaptal,

Maraninchi,

Musto

et al. 2024

Cells

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“…Additionally, excessive caffeine consumption can have negative effects on cardiovascular health, and consulting with a healthcare professional is recommended for personalized advice on caffeine consumption and cardiovascular health. [21] Caffeine has many effects on the cardiovascular system. Adenosine acts on specific receptors in the heart and is a negative inotropic and chronotropic drug.…”

Section: Cardiovascular Systemmentioning

confidence: 99%

The Use of Caffeine Products in Saudi Arabia

Rara,

Alhindi,

Alotaibi

et al. 2023

Pharmacogn. Res.

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The most used psychoactive substance globally is caffeine. Recently, the introduction of numerous products containing caffeine, as well as shifts in the consumption of both natural and artificial sources of caffeine, has received the attention of health experts. However, there is a lack of information on the consumption patterns of coffee and caffeinated products in different regions of the Saudi population. Therefore, this review aims to identify gender differences, pharmacological effects and risk of toxicity among caffeine product users in Saudi Arabia. Although there are regulations from the Saudi Food and Drug Authority (SFDA), there have been concerns about excessive caffeine consumption among the youth population. According to the available studies, the prevalence of coffee consumption is high among Saudi females. The extent of caffeine toxicity in Saudi Arabia is not well documented; however, given the widespread use of caffeine in the country, it is possible that instances of caffeine toxicity may arise. It should be emphasized that caffeine toxicity is not common and usually occurs only with extremely high levels of caffeine consumption. This review offers valuable insights into caffeine consumption patterns in Saudi Arabia, which can benefit a range of stakeholders, including scientists, healthcare providers and consumers. To ensure safe caffeine consumption and minimise the risk of negative outcomes arising from insufficient knowledge about its use, there is a need to educate individuals and raise public awareness about caffeine intake.

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Coffee consumption and cardiometabolic health: a comprehensive review of the evidence

Ungvari,

Kunutsor

2024

GeroScience

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This review provides a comprehensive synthesis of longitudinal observational and interventional studies on the cardiometabolic effects of coffee consumption. It explores biological mechanisms, and clinical and policy implications, and highlights gaps in the evidence while suggesting future research directions. It also reviews evidence on the causal relationships between coffee consumption and cardiometabolic outcomes from Mendelian randomization (MR) studies. Findings indicate that while coffee may cause short-term increases in blood pressure, it does not contribute to long-term hypertension risk. There is limited evidence indicating that coffee intake might reduce the risk of metabolic syndrome and non-alcoholic fatty liver disease. Furthermore, coffee consumption is consistently linked with reduced risks of type 2 diabetes (T2D) and chronic kidney disease (CKD), showing dose-response relationships. The relationship between coffee and cardiovascular disease is complex, showing potential stroke prevention benefits but ambiguous effects on coronary heart disease. Moderate coffee consumption, typically ranging from 1 to 5 cups per day, is linked to a reduced risk of heart failure, while its impact on atrial fibrillation remains inconclusive. Furthermore, coffee consumption is associated with a lower risk of all-cause mortality, following a U-shaped pattern, with the largest risk reduction observed at moderate consumption levels. Except for T2D and CKD, MR studies do not robustly support a causal link between coffee consumption and adverse cardiometabolic outcomes. The potential beneficial effects of coffee on cardiometabolic health are consistent across age, sex, geographical regions, and coffee subtypes and are multi-dimensional, involving antioxidative, anti-inflammatory, lipid-modulating, insulin-sensitizing, and thermogenic effects. Based on its beneficial effects on cardiometabolic health and fundamental biological processes involved in aging, moderate coffee consumption has the potential to contribute to extending the healthspan and increasing longevity. The findings underscore the need for future research to understand the underlying mechanisms and refine health recommendations regarding coffee consumption.

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Impact of Coffee Consumption on Cardiovascular Health

Cited by 10 publications

References 43 publications

Low Density Lipoprotein Cholesterol Decreases the Expression of Adenosine A2A Receptor and Lipid Rafts-Protein Flotillin-1: Insights on Cardiovascular Risk of Hypercholesterolemia

Low Density Lipoprotein Cholesterol Decreases the Expression of Adenosine A2A Receptor and Lipid Rafts-Protein Flotillin-1: Insights on Cardiovascular Risk of Hypercholesterolemia

The Use of Caffeine Products in Saudi Arabia

Coffee consumption and cardiometabolic health: a comprehensive review of the evidence

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