Impact of coasting in patients undergoing controlled ovarian stimulation with the gonadotropin-releasing hormone antagonist cetrorelix

Bahçeci, Mustafa; Uluğ, Ulun; Tosun, Süleyman; Erden, Halit Firat; Bayazit, Numan

doi:10.1016/j.fertnstert.2005.10.037

Cited by 7 publications

(8 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The use of coasting in GnRH antagonist protocols was first described in case reports that showed no compromise of IVF outcome (11,12). A similar conclusion was reached in the first cohort study of coasting in 29 GnRH antagonist cycles, which was reported by Bahceci et al (13) in 2006.…”

Section: Discussionmentioning

confidence: 59%

“…In GnRH agonist cycles, cycle cancellation should be discussed in cases of a longer duration (9). In GnRH antagonist protocols, prolonged coasting was not needed (Table 2), and Bahceci et al (13) reported similar pregnancy rates after prolonged coasting in GnRH antagonist protocols.…”

Section: Discussionmentioning

confidence: 99%

“…In our study, we compared embryo quality only in coasted cycles. We did not include a comparison with noncoasted cycles, although previous studies of embryo quality after coasting have suggested that coasting causes a reduction in oocyte quality in both GnRH agonist protocols (17) and GnRH antagonist protocols (13). Moreover, there are data suggesting that a profound drop in E 2 level (<1000 pg/mL) in GnRH agonist protocols may be related to low oocyte quality (16).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

In vitro fertilization cycle outcome after coasting in gonadotropin-releasing hormone (GnRH) agonist versus GnRH antagonist protocols

Farhi

Ben-Haroush

Lande

et al. 2009

Fertility and Sterility

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

In vitro fertilization cycle outcome after coasting in gonadotropin-releasing hormone (GnRH) agonist versus GnRH antagonist protocols

Farhi

Ben-Haroush

Lande

et al. 2009

Fertility and Sterility

View full text Add to dashboard Cite

“…Coasting has been mostly employed in GnRHa-based protocols, whereas few studies have described IVF outcomes in cycles using this strategy within the GnRH-ant cycles. 32,33 One retrospective case-control study in high responders showed that the need to initiate coasting was significantly lower in GnRH-ant as compared with GnRHa-based protocols (1.5% versus 6.9%; p < 0.001). 34 If coasting was initiated, the E 2 levels dropped to lower levels on the day of hCG and no patient was coasted for >2 days in the GnRH-ant group (N ¼ 45) versus 5.8% in the agonist group (N ¼ 329).…”

Section: Coasting In Gnrh Agonist Versus Gnrh Antagonist Cyclesmentioning

confidence: 99%

Withholding Gonadotropins Until Human Chorionic Gonadotropin Administration

Abdallah

Kligman²,

Davis³

et al. 2010

Semin Reprod Med

View full text Add to dashboard Cite

Withholding gonadotropins in women who exhibit high estradiol responses before follicles reach full maturation is called "coasting." Coasting, or suspending gonadotropin administration, can be an effective strategy for decreasing the risk of ovarian hyperstimulation syndrome (OHSS) while reducing cancelation rates. In in vitro fertilization cycles, mechanistically it is believed that withholding gonadotropins starves smaller follicles, induces apoptosis, and decreases the potential for these follicles to elaborate vascular endothelial growth factor, a known mediator of OHSS. It is generally accepted that coasting should be initiated when the estradiol (E₂) level is >3000 pg/mL in the setting of immature follicles. The human chorionic gonadotropin (hCG) trigger should be administered when the E₂ level subsequently drops to a "safe" level. Cycle cancellation should be considered if, after 3 to 4 days of coasting, the E₂ level remains excessively elevated. Oocyte retrieval may also be cancelled if the E₂ level on the day after hCG trigger drops precipitously. In gonadotropin-releasing hormone agonist (GnRHa)-based protocols, one can consider withholding GnRHa administration if the E₂ level continues to increase after a few days of coasting. Current data seem to show that the coasting period is short and/or is less likely to be required in GnRH-antagonist protocols as compared with GnRHa-based protocols. Large randomized control trials are still needed to establish the relative efficacy of coasting versus embryo cryopreservation in the context of OHSS prevention.

show abstract

“…As was previously mentioned in the early studies, no strict, evidence-based criteria were established regarding the initial estradiol level (E 2 i) to start coasting that would not compromise oocyte/embryo quality or implantation capacity of the embryos. Moreover, there is not a safety threshold of E 2 d that determines whether to cancel or continue the IVF cycle (2)(3)(4)(5).…”

Section: To the Editormentioning

confidence: 99%

Coasting resulting in a sharp decline in serum estradiol does not compromise implantation

Özmen

Isbacar

Aytaç

et al. 2010

Fertility and Sterility

View full text Add to dashboard Cite

Impact of coasting in patients undergoing controlled ovarian stimulation with the gonadotropin-releasing hormone antagonist cetrorelix

Cited by 7 publications

References 17 publications

In vitro fertilization cycle outcome after coasting in gonadotropin-releasing hormone (GnRH) agonist versus GnRH antagonist protocols

In vitro fertilization cycle outcome after coasting in gonadotropin-releasing hormone (GnRH) agonist versus GnRH antagonist protocols

Withholding Gonadotropins Until Human Chorionic Gonadotropin Administration

Coasting resulting in a sharp decline in serum estradiol does not compromise implantation

Contact Info

Product

Resources

About