Impact of co-exposure to titanium dioxide nanoparticles and Pb on zebrafish embryos

Hu, Shengchao; Han, Jian; Yang, Lihua; Li, Sen; Guo, Yongyong; Zhou, Bingsheng; Wu, Hongjuan

doi:10.1016/j.chemosphere.2019.06.009

Cited by 33 publications

(13 citation statements)

References 47 publications

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“…In this regard, nano-TiO 2 and Cr(VI) was chosen as the model contaminant to mimic the environmental conditions and evaluate how they influence their toxicity over one another. Although several studies dealt with mixture effects of nano-TiO 2 and heavy metals on freshwater organisms (Hu et al, 2019;Li et al, 2017Li et al, , 2016Luo et al, 2018), there are limited studies on their effects on marine organisms. Balbi et al (2014) reported no alteration in the bioavailability, bioconcentration and toxicity profile of Cd 2+ upon co-exposure with nano-TiO 2 to the marine bivalve Mytilus galloprovincialis.…”

Section: Introductionmentioning

confidence: 99%

Combined effects of nano-TiO2 and hexavalent chromium towards marine crustacean Artemia salina

et al. 2020

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There has been a significant increased concern of the impact of the toxicity of multiple contaminants in the marine environment. Thus, this study was aimed at determining whether the interaction between nano-TiO 2 and Cr(VI) would modulate their toxic effects with the marine crustacean, Artemia salina. Nano-TiO 2 agglomerated in artificial sea water (ASW) and readily formed micron-sized particles that settled down in the medium. The addition of Cr(VI) to nano-TiO 2 aggravated their agglomeration through sorption of Cr(VI) onto nano-TiO 2 . This was reflected by a decrease in the residual concentration of Cr in the suspension. Acute toxicity tests performed using pristine nano-TiO 2 (0.25, 0.5, 1, 2, and 4 mg/L) and Cr(VI) (0.125, 0.25, 0.5, and 1 mg/L) displayed a concentration dependent rise in the mortality of Artemia salina. To examine the effects of mixtures of nano-TiO 2 and Cr(VI) on Artemia salina, two groups of experiments were designed. The former group studied the toxic effect of nano-TiO 2 (0.5, 1, 2, and 4 mg/L) with a fixed concentration (0.125 mg/L) of Cr(VI). While the latter group studied the toxicity of Cr(VI) (0.25, 0.5, and 1 mg/L) with a fixed concentration (0.25 mg/L) of nano-TiO 2 . The toxic effects of nano-TiO 2 was not significantly reduced at a fixed concentration of Cr(VI) but in contrast, a significant reduction in the Cr(VI) toxicity by fixed concentration of nano-TiO 2 was observed. Toxicity data was well supported by an independent action model that proved the mode of action between nano-TiO 2 and Cr(VI) to be antagonistic. Furthermore, ROS generation and measurement of antioxidant enzyme activities were also in line with toxicity results. From this study, the modification of Cr(VI) toxicity at fixed concentration of nano-TiO 2 could have a huge impact on the reduction in Cr(VI) toxicity across trophic levels.

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Section: Introductionmentioning

confidence: 99%

Combined effects of nano-TiO2 and hexavalent chromium towards marine crustacean Artemia salina

et al. 2020

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“…A downregulation was observed in the expression of all three genes. These results indicated that the presence of TiO 2 NPs could enhance the neurotoxicity effects of Pb in zebrafish during the development [62].…”

Section: Effects Of Tiomentioning

confidence: 76%

“…All these perturbations indicated that TiO 2 NPs could induce toxicity in the thyroid endocrine system and the development of the zebrafish CNS [61]. In a similar study, embryos were treated with Pb or Pb plus TiO 2 NP for 2 days with a subsequent depuration (144 h) [62]. The uptake and complex formation between TiO 2 NPs and Pb were assessed by transmission electron microscopy-energy dispersive spectrometry (TEM-EDS).…”

Section: Effects Of Tiomentioning

confidence: 94%

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Effects of Metal Oxide Nanoparticles in Zebrafish

d’Amora

Schmidt

Konstantinidou

et al. 2022

Oxidative Medicine and Cellular Longevity

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Metal oxide nanoparticles (MO NPs) are increasingly employed in many fields with a wide range of applications from industries to drug delivery. Due to their semiconducting properties, metal oxide nanoparticles are commonly used in the manufacturing of several commercial products available in the market, including cosmetics, food additives, textile, paint, and antibacterial ointments. The use of metallic oxide nanoparticles for medical and cosmetic purposes leads to unavoidable human exposure, requiring a proper knowledge of their potentially harmful effects. This review offers a comprehensive overview of the possible toxicity of metallic oxide nanoparticles in zebrafish during both adulthood and growth stages, with an emphasis on the role of oxidative stress.

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“…Another study found that dietary TiO 2 NPs did not affect SOD-1 expression, slightly suppressed GPx transcription and significantly upregulated GR expression in O. mykiss compared with the control group, although it altered the transcription process of the glutathione-related genes (Shah et al, 2017). Different findings, in D. rerio embryo TiO 2 NPs, could induce upregulation of metallothionein (Hu et al, 2019). O. niloticus (Figure 4) which received TiO 2 NP-contaminated feed, and were challenged against A. hydrophila, had a higher MR% than controls.…”

Section: Discussionmentioning

confidence: 95%

The deleterious impacts of dietary titanium dioxide nanoparticles on the intestinal microbiota, antioxidant enzymes, diseases resistances and immune response of Nile tilapia

Sherif¹,

El–Sharawy

El-Samannoudy

et al. 2021

Aquac Res

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Titanium dioxide nanoparticles (TiO 2 NPs) are used in numerous products, such as paints, pharmaceuticals, environmental sanitizing agents and even as a whitening food additive (E171). Residual TiO 2 NPs are considered among the emerging contaminants of aquatic environments. However, the effect of such exposure on intestinal microbiota population, microbial disease resistance and the immune-related gene expression of Nile tilapia (Oreochromis niloticus) is largely obscure. Three groups of fish were nurtured on diets containing 1 mg/ml TiO2 NPs with three different sizes (53, 31 and 13 nm), beside the control group for four weeks before sampling fish tissues. Fish groups fed on TiO 2 NPs diets showed significantly increased higher levels of tumour necrosis factor (TNFα), interleukin (IL-6) and IL-1β, along with insignificant changes in IL-8 and IL-10 compared with the control group. These changes indicate a strong inflammatory response. Treated fish groups showed a marked decrease in the count of some intestinal microbiota, aeromonas, pseudomonas and lactobacillus. Fish were challenged against A. hydrophila, and a higher mortality rate was observed in the group fed on smaller TiO 2 NPs (13 nm). The levels of antioxidant enzymes such as catalase, glutathione peroxidase and superoxide dismutase were significantly increased in groups fed on TiO 2 NPs, while metallothionein levels were only slightly changed.In conclusion, feeding fish with diets containing TiO 2 NPs (13 and 31 nm) for 4 weeks alters the intestinal microbiota population and provides additional information on the toxic impacts of TiO 2 NPs on the health and immune status of O. niloticus.

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Impact of co-exposure to titanium dioxide nanoparticles and Pb on zebrafish embryos

Cited by 33 publications

References 47 publications

Combined effects of nano-TiO2 and hexavalent chromium towards marine crustacean Artemia salina

Combined effects of nano-TiO2 and hexavalent chromium towards marine crustacean Artemia salina

Effects of Metal Oxide Nanoparticles in Zebrafish

The deleterious impacts of dietary titanium dioxide nanoparticles on the intestinal microbiota, antioxidant enzymes, diseases resistances and immune response of Nile tilapia

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