Impact of clinicopathologic factors on survival in patients with sebaceous carcinoma of the eyelid — a population-based analysis

Lee, Ivan J.; Koh, John

doi:10.1080/01676830.2018.1505922

Cited by 8 publications

(21 citation statements)

References 41 publications

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“…We confirmed previous findings of old age at diagnosis and female predominance in SC patients (Chao et al 2001; Shields et al 2004; Muqit et al 2004; Song et al 2008; Muqit et al 2013; Wang et al 2013; Lee & Koh 2019; Sa et al 2019). As previously observed, the upper eyelid was the most common anatomic location of SC; this is due to the larger Meibomian glands in the upper tarsal plate (Muqit et al 2004; Song et al 2008; Muqit et al 2013; Sa et al 2019).…”

Section: Discussionsupporting

confidence: 92%

“…Despite the diagnostic delay, the tumours in our study were generally small, T1 in 56% according to AJCC TNM staging, 8th Edition. In the study from the Surveillance, Epidemiology, and End Results (SEER) database in the United States with 297 patients who had a SC of the eyelid, tumour size at presentation was T1 in 63% of patients, and T2 in 22% and T3 or greater in 16% of patients (Lee & Koh 2019), as compared T2 in 31%, and T3 or greater in 9% of our patients.…”

Section: Discussionmentioning

confidence: 74%

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Sebaceous carcinoma of the eyelid: 21‐year experience in a Nordic country

Niinimäki

Siuko

Tynninen

et al. 2020

Acta Ophthalmologica

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Purpose To evaluate the clinical features, diagnostic challenges, management, and prognosis of sebaceous carcinoma (SC) of the eyelids and periocular region in a Nordic country. Methods Patients were identified from the Finnish Cancer Registry and the Helsinki University Hospital databases during the 21‐year period 1998–2018. Age, sex, location, clinical and histopathologic diagnosis, treatment and outcome were registered. Results Sebaceous carcinoma (SC) was diagnosed in 32 patients. The incidence was 0.6 per million. Median age at the time of histopathologic diagnosis was 74 years, and 72% of patients were women. Diagnostic delay was often long, median 12 months. The most common cause for delay was misdiagnosis (72%): a chalazion in 34% and a benign tumour in 22%. The most common location was the upper eyelid (53%) and tumour type a solitary nodule (94%). The SC was not correctly diagnosed in 12 (40%) of 30 preoperative biopsies. The treatment for 31 (97%) patients was complete surgical removal with reconstruction. Conjunctival intraepithelial growth was found in 50%. The leading postoperative problem was ocular irritation (30%). During a median follow‐up of 58 months, two patients (6%) experienced a local recurrence and one patient died from metastatic SC. Conclusions The estimated incidence of SC in Finland was somewhat higher than in other Western countries. The diagnosis was often markedly delayed. Especially differentiation from chalazion continues to be essential. To improve outcomes, it is essential to inform the pathologist about the possibility of SC in eyelid biopsies and specimens and ideally submit them to an ophthalmic pathology service.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 74%

Sebaceous carcinoma of the eyelid: 21‐year experience in a Nordic country

Niinimäki

Siuko

Tynninen

et al. 2020

Acta Ophthalmologica

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“…Studies have demonstrated that elderly patients with SAC are more likely to have poor prognosis. 6,7 On the contrary to previous reports on eyelid and periocular SAC where young and middle-aged patients had similar prognosis, 7,8 the authors found younger than 40 years independently indicated better prognosis than age between 40 and 59 years. Thus, it was clear with the supplement of the authors' finding that the older patients developed SAC, the worse their prognosis would be.…”

Section: Discussionmentioning

confidence: 75%

“…Furthermore, the authors supposed that the female survival advantage could possibly come from extraocular SAC. All the abovementioned eyelid or head/neck SAC research found no survival difference for sex, 5,7,10,13 whereas Tripathi and colleagues and the authors' research found male patients would have worse prognosis when more extraocular SAC was involved because extraocular and periocular SAC might originate differently. 1,3…”

Section: Discussionmentioning

confidence: 85%

Clinical Features and Prognosis of Young and Middle-Aged Adults With Skin Sebaceous Adenocarcinoma

Wang

Jiang

2022

Dermatol Surg

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“…In a chinese study of 238 patients, risk factors for tumor-related death were orbital involvement, the greatest tumor basal diameter, pagetoid spread and lymph node metastasis at initial diagnosis [62]. From United States Sa et al [15] report in study of 100 patients, that T3b or worse (AJCC 8-th edition) and N1 are risk factors for death, Lee et al [63] report in study of 940 patients, that older age and greater tumor size correlate with decreased overall survival, whereas surgical treatment or combined surgical and radiation treatment correlate with increased overall survival.…”

Section: Follow-upmentioning

confidence: 99%

Nordic treatment practices survey and consensus for treatment of eyelid sebaceous carcinoma

et al. 2020

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Background: The purpose was to describe the Nordic treatment practices and to reach a Nordic consensus for the treatment of sebaceous eyelid carcinoma. Methods: The treatment practices data was collected by a questionnaire with 37 questions to the Nordic oculoplastic surgeons and analyzed. A PubMed MEDLINE database search was done to gather data on the published treatment practices and recommendations. A working group that consisted of in minimum one senior consultant from each leading Nordic University Eye Hospital was assigned. A structured interactive method was used to establish the consensus. Results: Twenty-four doctors responded to the questionnaire. 23/24 (96%) of the respondents took a biopsy before surgery. Regional lymph node scanning was routinely done by 14/23 (61%) and a systemic screening of a metastatic disease by 13/23 (57%). 6/22 (27%) never took conjunctival mapping biopsies and 12/23 (52%) never screened for Muir-Torre. Respondents used Mohs surgery, frozen section or multi-stage excision with delayed closure, and 5-6 mm was the mostly preferred margin. Sentinel lymph node biopsy was a possible option for 9/22 (41%) and cryotherapy and Mitomycin C for 6/22 (27%) respondents. 50% of respondents considered radiation as a treatment option. 15/16 (94%) respondents always followed-up their patients, most for 5 years. Two thirds scanned regional lymph nodes during the follow-up. Consensus was reached for 18 statements representing three domains: preoperative work-up, treatment and follow-up. Conclusion: Treatment practices differ in between the five Nordic countries which have similar public health care systems. In the article the authors present a Nordic consensus for the treatment of eyelid sebaceous carcinoma.

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Impact of clinicopathologic factors on survival in patients with sebaceous carcinoma of the eyelid — a population-based analysis

Cited by 8 publications

References 41 publications

Sebaceous carcinoma of the eyelid: 21‐year experience in a Nordic country

Sebaceous carcinoma of the eyelid: 21‐year experience in a Nordic country

Clinical Features and Prognosis of Young and Middle-Aged Adults With Skin Sebaceous Adenocarcinoma

Nordic treatment practices survey and consensus for treatment of eyelid sebaceous carcinoma

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