Impact of cisplatin administration on cerebellar cortical structure and locomotor activity of infantile and juvenile albino rats: the role of oxidative stress

Mokhtar, Hanan E.L; Hulail, Mohey; Mahmoud, Samar; Yousef, Doaa Mohammed

doi:10.1007/s12565-021-00624-9

Cited by 4 publications

(10 citation statements)

References 105 publications

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“…These results are in concordance with previous results [27,28]. Cisplatin causes gastrointestinal toxicity and diarrhea and it is a highly emetogenic agent leading to a decrease in appetite [29,30]. In addition, the reduction of the body weight in cisplatin-treated rats might be in part attributed to the direct toxic effect of cisplatin on renal tubules that caused a reduction in water reabsorption and excessive sodium excretion with subsequent polyuria, dehydration, and reduction of body weight [31].…”

Section: Discussionsupporting

confidence: 91%

Melatonin Mitigates Cisplatin-Induced Ovarian Dysfunction via Altering Steroidogenesis, Inflammation, Apoptosis, Oxidative Stress, and PTEN/PI3K/Akt/mTOR/AMPK Signaling Pathway in Female Rats

et al. 2022

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Ovarian damage and fertility impairment are major side effects of chemotherapy in pre-menopausal cancer patients. Cisplatin is a widely used chemotherapeutic drug. The present study was designed to assess the ameliorative effects of melatonin as an adjuvant for fertility preservation. Thirty-two adult female Wistar rats were divided randomly into four equal groups: Control, Melatonin, Cisplatin (CP) treated, and CP + Melatonin treated. The cisplatin-treated group showed decreased body and ovarian weights, decreased serum E2 and AMH, increased serum LH and FSH, reduced ovarian levels of SOD, CAT, GSH, and TAC, and increased ovarian MDA. The histopathological examination of the cisplatin-treated group showed deleterious changes within ovarian tissue in the form of damaged follicles and corpus luteum, hemorrhage, and inflammatory infiltrates with faint PAS reaction in zona pellucida, increased ovarian collagen deposition, and marked expression of caspase-3 immune reaction in granulosa and theca cells, stroma, and oocytes. Alongside, there was a significant downregulation in the mRNA expression of steroidogenic enzymes, IL10, AMPK, PI3K, AKT, mTOR, and PTEN, while TGF-β1, IL1β, IL6, TNF-α, NF-Kβ, P53, p38-MAPK, JNK, and FOXO3 mRNA expressions were upregulated in cisplatin-treated rats’ ovarian tissue. Coadministration of cisplatin-treated rats with melatonin reversed these changes significantly. In conclusion, melatonin’s antioxidant, anti-inflammatory, and anti-apoptotic activities could modulate ovarian disturbances induced by cisplatin and preserve fertility.

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Section: Discussionsupporting

confidence: 91%

Melatonin Mitigates Cisplatin-Induced Ovarian Dysfunction via Altering Steroidogenesis, Inflammation, Apoptosis, Oxidative Stress, and PTEN/PI3K/Akt/mTOR/AMPK Signaling Pathway in Female Rats

et al. 2022

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“… 1 , 2 , 7 It is known that ROS can attack polyunsaturated fatty acids of cellular membranes, resulting in functional and/or structural damage to the membranes and eventually initiate lipid peroxidation (LPO). 29 , 30 MDA is the end product of LPO, resulting from lipid peroxide decomposition. 29 MDA causes cross‐linking and polymerisation of the membrane components, thus exacerbating the damage caused by LPO.…”

Section: Discussionmentioning

confidence: 99%

“… 29 MDA causes cross‐linking and polymerisation of the membrane components, thus exacerbating the damage caused by LPO. 30 Therefore, increased MDA, a product of LPO, may indicate oxidative stress‐related brain damage. 31 According to the literature review, the increase in MDA levels in brain tissue is closely related to neuronal degeneration in CIS toxicity.…”

Section: Discussionmentioning

confidence: 99%

“… 37 There are many studies documenting a decrease in the amount of GSH and activity of GPx in CIS‐induced oxidative brain damage. 1 , 3 , 9 , 30 It is thought that the negative effects of LPO and the decrease in the concentrations of GSH and GPx in the brain play an important role in the toxicity of CIS. 1 , 9 , 30 In our study, we found a decrease in the amount of endogenous tGSH with increasing MDA level in the brain of CIS administered mice.…”

Section: Discussionmentioning

confidence: 99%

“… 1 , 3 , 9 , 30 It is thought that the negative effects of LPO and the decrease in the concentrations of GSH and GPx in the brain play an important role in the toxicity of CIS. 1 , 9 , 30 In our study, we found a decrease in the amount of endogenous tGSH with increasing MDA level in the brain of CIS administered mice. In the literature, no studies investigating the effect of tangeretin on decreased tGSH levels and GPx activity in CIS‐induced brain damage were found.…”

Section: Discussionmentioning

confidence: 99%

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Effect of tangeretin on cisplatin‐induced oxido‐inflammatory brain damage in rats

Cicek,

Danisman,

Bolat

et al. 2024

J Cellular Molecular Medi

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Cisplatin (CIS) is a platinum‐derived chemotherapeutic agent commonly utilized in the treatment of various malignant tumours. However, anticancer doses of the drug cause serious damage to the brain. This study aimed to determine the potential protective effects of tangeretin, which has antioxidant and anti‐inflammatory properties, in cisplatin‐induced neurotoxicity on BALB/c mice brains. Male BALB/c mice were randomized and separated into four groups. Tangeretin was given for 10 days by gavage. CIS was injected as a single dose of 10 mg/kg intraperitoneally (ip) on the 10th day. Brain tissues, malondialdehyde (MDA), total glutathione (tGSH), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT) and nitric oxide (NO) levels were measured to determine oxidative damage and myeloperoxidase, tumour necrosis factor‐alpha (TNF‐α), interleukin 1 beta (IL‐1β), IL‐6 and IL‐10 were measured to determine inflammatory activity. In addition, 8‐OHdG and caspase‐3 were analysed by immunofluorescence methods. While CIS administration remarkably elevated reactive oxygen species, MDA, and NO levels in brain tissue compared to the control, tGSH, GPx, SOD and CAT levels were significantly decreased. Also, it has been detected that TNF‐α, IL‐1β and IL‐6 obtained in CIS‐treated groups increased as well as IL‐10 decreased, thereby elevating the inflammatory response. In addition, 8‐OHdG and caspase‐3 immunoreactivity in neurons increased with CIS administration. Treatment with tangeretin ameliorated the deterioration in oxidant/antioxidant status, overpowered neuroinflammation and ameliorated neurotoxicity‐induced apoptosis. This study shows that tangeretin has beneficial effects on CIS‐induced neurodegeneration. Possible mechanisms underlying these beneficial effects include the antioxidant and anti‐inflammatory properties of tangeretin.

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Tempol maintained the cellular integrity of the cerebellar cortex by preserving neuron survival, autophagy, glial cells, and synapses after cisplatin exposure

Sewelam,

Amin,

Abdelmohsen

et al. 2024

Translational Research in Anatomy

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Impact of cisplatin administration on cerebellar cortical structure and locomotor activity of infantile and juvenile albino rats: the role of oxidative stress

Cited by 4 publications

References 105 publications

Melatonin Mitigates Cisplatin-Induced Ovarian Dysfunction via Altering Steroidogenesis, Inflammation, Apoptosis, Oxidative Stress, and PTEN/PI3K/Akt/mTOR/AMPK Signaling Pathway in Female Rats

Melatonin Mitigates Cisplatin-Induced Ovarian Dysfunction via Altering Steroidogenesis, Inflammation, Apoptosis, Oxidative Stress, and PTEN/PI3K/Akt/mTOR/AMPK Signaling Pathway in Female Rats

Effect of tangeretin on cisplatin‐induced oxido‐inflammatory brain damage in rats

Tempol maintained the cellular integrity of the cerebellar cortex by preserving neuron survival, autophagy, glial cells, and synapses after cisplatin exposure

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