Impact of Cinnamon Supplementation on cardiometabolic Biomarkers of Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Zhu, Changyou; Yan, Hongmei; Yin, Zheng; Santos, Heitor O.; Macit, Melahat Sedanur; Zhao, Ketong

doi:10.1016/j.ctim.2020.102517

Cited by 26 publications

(16 citation statements)

References 43 publications

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“…Since 2000, bioactive compounds including EOs, cinnamaldehyde, phenolic compounds and others have been included in poultry feed to improve immunity, metabolism, health, growth performance, carcass traits and meat quality. The bioactive compounds of cinnamon have potent anti-inflammatory, anti-microbial and antioxidant properties with free radical scavenging actions and strong inhibitory effects on nitric oxide (NO) production by inhibiting the activity of NFκβ [24]. In studies conducted with broiler chickens, anti-microbial (antiviral, antibacterial and antifungal) activities against many microorganisms and strong antioxidant activities have been observed in poultry diets supplemented with cinnamon and their EOs.…”

Section: Utilization Of Cinnamon In Poultry Feedmentioning

confidence: 99%

Cinnamon: A Natural Feed Additive for Poultry Health and Production—A Review

Ali

Ponnampalam

Pushpakumara

et al. 2021

Animals

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The increased bacterial resistance to synthetic antibiotics and consumer awareness about the health and food safety concerns have triggered the ban on the use of antibiotic growth promotors (AGPs) in the poultry industry. This situation encouraged the poultry sector and industry to explore safe alternatives to AGPs and focus on developing more sustainable feed management strategies to improve the intestinal health and growth performance of poultry. Consequently, phytogenic feed additives (PFAs) have emerged as natural alternatives to AGPs and have great potential in the poultry industry. In recent years, cinnamon (one of the most widely used spices) has attracted attention from researchers as a natural product with numerous health benefits for poultry. The essential oils in cinnamon, in particular, are of interest because of their antioxidant, anti-microbial, anti-inflammatory, antifungal, and hypocholesterolaemic effects, in addition to their ability to stimulate digestive enzymes in the gut. This review mainly emphasizes the potential impact of cinnamon as a natural feed additive on overall gut health, nutrient digestibility, blood biochemical profile, gene expression, gut microbiota and immune response.

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Section: Utilization Of Cinnamon In Poultry Feedmentioning

confidence: 99%

Cinnamon: A Natural Feed Additive for Poultry Health and Production—A Review

Ali

Ponnampalam

Pushpakumara

et al. 2021

Animals

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“…Third, we encourage further RCT to assess these markers, as well as crossover acute studies using transabdominal ultrasound to allow the examination of the gastric emptying on meal tests with and without chitosan supplementation. At last, further research is also required to better understand the effects of chitosan on the gut microbiota, as well as on advanced biomarkers of the lipid profile (e.g., lipoprotein (a) and small dense low-density lipoprotein-cholesterol) and inflammatory and oxidative status due to their emerging scientific attention to disease management [ 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

The effects of chitosan supplementation on anthropometric indicators of obesity, lipid and glycemic profiles, and appetite-regulated hormones in adolescents with overweight or obesity: a randomized, double-blind clinical trial

et al. 2022

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Background Chitosan is one of dietary fiber that has received great attention in improving obesity-related markers, but little is known on its effects on adolescents. Objectives To analyze the effects of chitosan supplementation on obesity-related cardiometabolic markers and appetite-related hormones in adolescents with overweight or obesity. Methods and analysis A randomized clinical trial was performed on 64 adolescents with overweight and obesity, who were randomly allocated to receive chitosan supplementation (n = 32) or placebo as control (n = 32) for 12 weeks. Anthropometric measures, lipid and glycemic profiles, and appetite-related hormones were examined. Results Sixty-one participants completed study (chitosan = 31, placebo = 30). Chitosan supplementation significantly improved anthropometric indicators of obesity (body weight: − 3.58 ± 2.17 kg, waist circumference: − 5.00 ± 3.11 cm, and body mass index: − 1.61 ± 0.99 kg/m2 and − 0.28 ± 0.19 Z-score), lipid (triglycerides: − 5.67 ± 9.24, total cholesterol: − 14.12 ± 13.34, LDL-C: − 7.18 ± 10.16, and HDL-C: 1.83 ± 4.64 mg/dL) and glycemic markers (insulin: − 5.51 ± 7.52 μIU/mL, fasting blood glucose: − 5.77 ± 6.93 mg/dL, and homeostasis model assessment of insulin resistance: − 0.24 ± 0.44), and appetite-related hormones (adiponectin: 1.69 ± 2.13 ng/dL, leptin − 19.40 ± 16.89, and neuropeptide Y: − 41.96 ± 79.34 ng/dL). When compared with the placebo group, chitosan supplementation had greater improvement in body weight, body mass index (kg/m2 and Z-score), waist circumference, as well as insulin, adiponectin, and leptin levels. Differences were significant according to P-value < 0.05. Conclusion Chitosan supplementation can improve cardiometabolic parameters (anthropometric indicators of obesity and lipid and glycemic markers) and appetite-related hormones (adiponectin, leptin, and NPY) in adolescents with overweight or obesity.

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“…The results of a new systematic review and meta‐analysis by Zhu show that cinnamon supplementation may be an adjuvant for reducing inflammation and oxidative stress levels in humans. They found that cinnamon supplementation significantly decreased C‐reactive protein (CRP), IL‐6, malondialdehyde (MDA), and increased total antioxidant capacity levels (Zhu et al., 2020).…”

Section: Discussionmentioning

confidence: 99%