Impact of Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) GFR Estimating Equations on CKD Prevalence and Classification Among Asians

Betzler, Bjorn Kaijun; Sultana, Rehena; He, Feng; Tham, Yih Chung; Lim, Cynthia Ciwei; Wang, Ya Xing; Nangia, Vinay; Tai, E Shyong; Rim, Tyler Hyungtaek; Бикбов, М.М.; Jonas, Jost B.; Kang, Se Woong; Park, Kyu Hyung; Cheng, Ching‐Yu; Sabanayagam, Charumathi

doi:10.3389/fmed.2022.957437

Cited by 12 publications

(9 citation statements)

References 31 publications

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“…In this study, the prevalence of CKD was assessed based on eGFR, which was estimated using the CKD-EPI 2021 calculation [ 17 , 18 ]. Because use of the equation has only recently increased, limited data are available for a large number of Korean patients [ 18 , 22 ]. In Korea, the Korea National Health and Nutrition Examination Survey (KNHANES) data, which are publicly available ( , accessed on 16 November 2022), include only laboratory data measured up to 2020, and the prevalence of CKD using eGFR is based on the CKD-EPI 2012 equation.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Iron Deficiency Anemia Indicated for Intravenous Iron Treatment in the Korean Population

et al. 2023

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We aimed to investigate the number and prevalence of patients indicated for intravenous iron treatment in a large Korean population using criteria based on laboratory test results in an effort to extract indirect information on the need for intravenous iron treatment. Between 1 January 2019 and 31 December 2021, a total of 83,994 Korean patients (30,499 men and 53,495 women) with a median age of 46 years (interquartile range, 30–61) were evaluated using iron deficiency anemia–associated laboratory tests and serum creatinine tests of estimated glomerular filtration rates. The overall prevalence of anemia (Hb ≤ 11 g/dL) was 16.5%, and the proportion of patients with possible chronic kidney disease who had an estimated glomerular filtration rate < 60 mL/min/1.73 m2 was 11.4%. The number of patients indicated for reimbursable intravenous iron treatment was higher in women than in men, higher in older patients, and higher in 2021 than in 2019 (all p < 0.001). The prevalence of patients indicated for reimbursable intravenous iron treatment was up to 30.0% in those ≥ 80 years of age in 2019. The results of this study provide basic knowledge about the use of iron deficiency anemia-associated laboratory tests in planning nutritional support programs using an intravenous iron formulation in Korea.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Iron Deficiency Anemia Indicated for Intravenous Iron Treatment in the Korean Population

et al. 2023

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“…The demographic and clinical data of all included IgAN patients, such as age, gender, 24-h urinary protein excretion (UPE), and serum creatinine (S.Cr) were recorded at the time of kidney biopsy. The estimated glomerular filtration rate (eGFR) was calculated using the Chronic Kidney Disease Epidemiology Collaboration equations using creatinine 2021 15 .…”

Section: Methodsmentioning

confidence: 99%

Urinary exosomal miRNA signature of IgA nephropathy: a case–control study

Shankar,

Shetty,

N.S.

et al. 2023

Sci Rep

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IgA nephropathy is the most common primary glomerulonephritis worldwide and can progress to end-stage kidney disease (ESKD). The current “gold standard” for diagnosis is kidney biopsy, which is invasive and associated with morbidity. miRNAs are small, non-coding endogenous RNA that may serve as non-invasive biomarkers, and that are found in urinary exosomes. Thus far, there is a paucity of studies of the miRNA profile for the diagnosis of IgA nephropathy. Hence, we aimed to study the urinary exosomal miRNA signature of Indian patients with IgA nephropathy. Fifty biopsy-proven IgA nephropathy patients, 50 healthy controls and 25 patients with ESKD (IgA nephropathy) were recruited over 2 years (2020–2022). Urinary exosomes were isolated from which miRNA was extracted . Analysis of urinary exosomal miRNA was done using the digital multiplexed nCounter® human v3 miRNA Expression Assay which contains 799 unique miRNA barcodes. Candidate miRNAs were identified using Lasso regression and consensus clustering. The mean age of IgA nephropathy patients was 36.32 ± 3.067 years, mean creatinine was 2.26 ± 0.318 mg/dl and mean proteinuria was 2.69 ± 0.64 g/day. Compared to healthy controls, the majority (N = 150) of miRNAs were significantly downregulated. Five candidate miRNAs (hsa.miR.146b.3p, hsa.miR.599, hsa.miR.4532, hsa.miR.664b.5p and hsa.miR.221.5p) were able to differentiate between IgA nephropathy cases and controls (AUC > 0.90); the presence of all 5 was associated with 100% specificity and sensitivity for diagnosing IgA nephropathy cases. This study of Indian patients identified that there was a significant difference in the urinary exosomal miRNA profile between IgA nephropathy cases and healthy controls, suggesting that miRNAs may be valuable in the non-invasive diagnosis of IgA nephropathy.

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“…The estimated glomerular filtration rate (eGFR) was calculated using the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, developed in 2021 [25,30]. The estimated renal function using the CKD-EPI equation was normalised for body surface area (BSA) and expressed as GFR mL/min/1.73 m 2 , correct for age and sex [142 * (serum creatinine/A) B * 0.9938 age * (1.012 if female); in male A = 0.9, B = −0.302 if serum creatinine ≤ 0.9, −1.2 if serum creatinine > 0.9; in female A = 0.7, B = −0.241 if serum creatinine ≤ 0.9, −1.2 if serum creatinine > 0.9].…”

Section: Renal Function Assessmentmentioning

confidence: 99%

Glomerular Hyperfiltration: A Marker of Fibrosis Severity in Metabolic Associated Steatotic Liver Disease in an Adult Population

Dalbeni,

Garbin,

Zoncapè

et al. 2023

IJMS

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Glomerular hyperfiltration (GH) is an increase in the glomerular filtration rate, possibly progressing to chronic kidney disease (CKD). Metabolic-associated steatotic liver disease (MASLD) is linked to an increased risk of CKD, especially if fibrosis is present; however, the association between GH and MASLD has not been explored. To evaluate GH prevalence in MASLD and its possible correlation with liver fibrosis. 772 consecutive patients with ultrasound MASLD (mean age 47.3 ± 8.9 years, 67.1% males) were enrolled. GH was defined as estimated glomerular filtration rate (eGFR) greater than the upper quartile of values in the cohort. Liver stiffness measurement (LSM) by FibroScan ≥ 7.2 kPa suggested liver fibrosis. GH was present in 20% of patients, liver fibrosis in 30%. In total, 53.4% of the cohort was obese, 40.9% hypertensive, 36.3% diabetic and 70.8% dyslipidaemic. GH patients compared to non-GH were significantly younger (38.4 ± 8.3 vs. 49.5 ± 7.7, p < 0.001), with higher prevalence of LSM > 7.2 kPa (35.5% vs. 29%, p < 0.001), without any difference in metabolic comorbidities. In multivariate analysis, age (OR 0.85, CI 95% 0.82–0.87) and significant fibrosis (OR 1.83; CI 95%1.10–3.03) remained independently associated with GH, regardless of the presence of metabolic alterations and nephrotoxic drugs. GH, an early marker of renal damage, is highly prevalent in MASLD and is associated with hepatic fibrosis. GH may be considered an early marker of both liver and renal disease and its recognition could prompt the management of risk factors aimed at preventing the progression of both hepatic and renal disease.

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Impact of Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) GFR Estimating Equations on CKD Prevalence and Classification Among Asians

Cited by 12 publications

References 31 publications

Prevalence of Iron Deficiency Anemia Indicated for Intravenous Iron Treatment in the Korean Population

Prevalence of Iron Deficiency Anemia Indicated for Intravenous Iron Treatment in the Korean Population

Urinary exosomal miRNA signature of IgA nephropathy: a case–control study

Glomerular Hyperfiltration: A Marker of Fibrosis Severity in Metabolic Associated Steatotic Liver Disease in an Adult Population

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