Impact of chronic hepatitis C virus infection on the survival of patients with oropharyngeal cancer

Economides, Minas P.; Amit, Moran; Mahale, Parag; Hosry, Jeff; Jiang, Ying; Bharadwaj, Uddalak; Torres, Harrys A.

doi:10.1002/cncr.31146

Cited by 9 publications

(6 citation statements)

References 24 publications

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“…As we discussed above, HCV might be a doubleedged sword in non-HPV associated HNSCC. Economides et al 18 found that anti-HCV treatment improved the prognosis of HCV-positive HNSCC patients, which is not against our findings. Anti-HCV treatment is mainly based on interferon alpha or direct-acting anti-viral agents (DAA), which both reduce HCV vial loads and stimulate immunity leading a better outcomes for HCVpositive patients.…”

Section: Discussioncontrasting

confidence: 70%

“…11 However, another retrospective study revealed that HCV infection increased tumor-specific mortality in patients with oropharyngeal cancer (HR = 2.15; 95% CI: 1.08-6.85; P = .02). 18 Besides, the anti-HCV treatment improved the 5-year survival rate of patients with oropharyngeal and oral cancers. 18,19 So far, there were also no investigations about the impact of HCV RNA transcript in the prognosis of non-HPV associated HNSCC.…”

Section: Discussionmentioning

confidence: 99%

“…18 Besides, the anti-HCV treatment improved the 5-year survival rate of patients with oropharyngeal and oral cancers. 18,19 So far, there were also no investigations about the impact of HCV RNA transcript in the prognosis of non-HPV associated HNSCC. Here, our results provide some theoretical indications that HCV RNA transcript may predict the 5-year overall survival time of non-HPV associated HNSCC independently.…”

Section: Discussionmentioning

confidence: 99%

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Hepatitis C Virus RNA Transcript Associates with Prognosis in Non‐human Papillomavirus Associated Head and Neck Squamous Cell Carcinoma

et al. 2021

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Objective/Hypothesis: Hepatitis C virus (HCV) was reported to associate with head and neck squamous cell carcinoma (HNSCC) in many studies. However, its correlation with prognosis of non-human papillomavirus (HPV) associated HNSCC remains unknown. Here, we sought to investigate clinical significance of HCV RNA transcript in non-HPV associated HNSCC by analyzing corresponding RNA-seq data.Study Design: A retrospective cohort study. Methods: Four hundred and forty-eight non-HPV associated HNSCC patients with aligned RNA-seq and clinical follow-up data were included and divided into two groups: low-HCV and high-HCV. Means of continuous variables and proportions of categorical variables were compared using independent sample t-test and chi-square test, respectively. Survival data were compared using Cox regression analysis, Kaplan-Meier curves, and log-rank test. Expression of genome-wide mRNAs and abundance of immune cells were compared using volcano plot and cell signature estimated score analysis.Results: HCV RNA transcript negatively correlates with pathologic (P = .028) and clinical-stage (P = .023), clinical N stage (P = .025), and nodal extracapsular spread (P = .042) and is an independent prognosis factor in non-HPV associated HNSCC (HR = 1.488; 95% CI: 1.004-2.206; P = .048). Elevated expression of HCV improved 5-year overall survival (43.6% vs. 53.2%; P = .035) in all non-HPV associated HNSCC patients, the same as in male (46.6% vs. 58.7%; P = .049), clinical M0 stage (42.8% vs. 52.9%; P = .036), white (42.9% vs. 55.9%; P = .010), and histologic grade 1 to 2 subgroups (42.1% vs. 57.2%; P = .043). The expression of several immune-related genes and abundance of some immune cells significantly changed with the increase of HCV RNA transcript, while HCV-related oncogenes and tumor suppressor gene did not.Conclusions: HCV RNA transcript is an independent favorable factor for prognosis of non-HPV associated HNSCC.

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Section: Discussioncontrasting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Hepatitis C Virus RNA Transcript Associates with Prognosis in Non‐human Papillomavirus Associated Head and Neck Squamous Cell Carcinoma

et al. 2021

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“… 29 , 30 However, in patients with oropharyngeal cancers, HCV infection correlated with an increased risk of cancer‐specific death and disease progression. 32 However, the oncologic significance of this is unclear. In our study, anti‐HCV seropositivity had no unfavorable impact on the 5‐year OS and PFS, even in the oropharyngeal subgroup.…”

Section: Discussionmentioning

confidence: 99%

“…29,30 However, in patients with oropharyngeal cancers, HCV infection correlated with an increased risk of cancer-specific death and disease progression. 32 However, the oncologic significance of Cirrhosis was defined based on typical radiologic findings (e.g., hepatic nodularity, massive ascites, and splenomegaly). e Renal impairment was defined as an eGFR < 60 ml/min/1.73 m 2 , calculated with the modification of diet in renal disease equation.…”

Section: Discussionmentioning

confidence: 99%

Survival outcomes of patients with head and neck squamous cell cancer with hepatitis B virus infection: An analysis from an endemic tertiary center

Lai

Lin

et al. 2022

Cancer Medicine

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Background Hepatitis B virus (HBV) affects the occurrence and survival outcome of various malignant disorders. The study aimed to evaluate the survival outcome of head and neck squamous cell cancer (HNSCC) patients with or without HBV infection. Methods This study included patients with HNSCC who visited Taichung Veterans General Hospital from 2007 to 2015. HBV infection was defined by hepatitis B surface antigen (HBsAg) seropositivity. By propensity score matching, we compared survival outcomes, including progression‐free survival (PFS) and overall survival (OS), among patients with or without HBV infection. Results The prevalence of HBV infection in our cohort was 12.3%. Among the 1,015 patients included in the matched analysis, a higher risk of baseline liver cirrhosis (11.3% vs. 3.4%, p < 0.001) and initial hepatic dysfunction (10.8% vs. 5.4%, p = 0.005) rates were observed than those without HBV infection at baseline. The 5‐year OS was 43.1% and 53.2% ( p < 0.001) and the 5‐year PFS was 37.4% and 42.3% ( p = 0.007) in patients with and without HBV infection, respectively. The incidence of subsequent hepatic dysfunction showed no difference between patients with and without HBV infection (29.6% vs. 26.8%, p = 0.439). Conclusions Patients with HNSCC and HBV infection were younger and had a higher risk of cirrhosis compared to those without HBV infection. Moreover, HBV infection significantly influenced the OS and PFS outcomes but not subsequent hepatic dysfunction in patients with HNSCC.

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Strategies to identify hepatitis C virus infection in patients receiving anticancer therapy: a cross-sectional study

Torres

Lok

Suarez‐Almazor

et al. 2020

Support Care Cancer

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Impact of chronic hepatitis C virus infection on the survival of patients with oropharyngeal cancer

Abstract: The early detection of HCV is important in patients with OPC because this infection may affect their oncologic outcomes. Cancer 2018;124:960-5. © 2017 American Cancer Society.

Cited by 9 publications

References 24 publications

Hepatitis C Virus RNA Transcript Associates with Prognosis in Non‐human Papillomavirus Associated Head and Neck Squamous Cell Carcinoma

Hepatitis C Virus RNA Transcript Associates with Prognosis in Non‐human Papillomavirus Associated Head and Neck Squamous Cell Carcinoma

Survival outcomes of patients with head and neck squamous cell cancer with hepatitis B virus infection: An analysis from an endemic tertiary center

Strategies to identify hepatitis C virus infection in patients receiving anticancer therapy: a cross-sectional study

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