Impact of childhood trauma on cognitive profile in bipolar disorder

Abstract

Our results confirmed that CT significantly impacts on cognitive performance during adulthood in BD. The data obtained suggest that a history of CT could act as a liability marker for cognitive impairment. A higher estimated IQ may act as a protective factor against cognitive decline in this group of patients.

Factors associated with poor functional outcome in bipolar disorder: sociodemographic, clinical, and neurocognitive variables

“…Patients with higher cognitive reserve present compensation mechanisms that are supposed to be more effective when compared to patients with lower cognitive reserve. These mechanisms allow a better social, occupational, and cognitive outcome, as it has been shown in recent literature . Although both years of education and estimated IQ correlated with functioning, in the present study, only estimated IQ was significant, and the results are in line with the aforementioned studies, suggesting that those patients with higher estimated IQ would present better functional outcome.…”

Schizotypal personality traits and social cognition are associated with childhood trauma exposure

“…This is consistent with similar findings from large samples comparing SZ cases to healthy individuals (Green, Chia, et al ., ), in a sample of cases with first‐episode psychosis (Kilian et al ., ), and samples of mixed psychotic cases grouped according to both their levels of psychopathology and trauma exposure (Mansueto et al ., ). However, these findings are at odds with several previous reports in trauma‐exposed healthy youths and adults (Hart & Rubia, ), adults with bipolar disorder (Bucker et al ., ; Jimenez et al ., ; Savitz et al ., ), and adult psychosis samples (Li et al ., ; Lysaker et al ., ; Shannon et al ., ). It is possible that the current study did not find a significant relationship between trauma exposure and cognitive functioning because some of the specific aspects of cognition shown to be associated with trauma exposure in these previous studies (e.g., higher order executive functioning such as response inhibition and novel problem solving) were not assessed in the present study.…”

“…The impact of trauma exposure on cognitive functions has been demonstrated in a number of studies of non‐psychotic (Hart & Rubia, ) and psychotic populations (Green, Chia, et al ., ; Jimenez et al ., ; Lysaker et al ., ; McCabe et al ., ; Savitz, van der Merwe, Stein, Solms, & Ramesar, ; Shannon et al ., ); affected cognitive domains include executive functions, working memory, attention, and memory. In psychotic samples, trauma exposure has been associated with more severe cognitive deficits in cases with established SZ (Green, Chia, et al ., ; Lysaker et al ., ; McCabe et al ., ; Mrizak et al ., 2016a; Shannon et al ., ), patients with BD (Jimenez et al ., ; Savitz et al ., ), and first‐episode psychosis (Aas et al ., ). Exposure to maltreatment in non‐clinical samples has also been associated with alterations of brain structure and/or function in regions implicated in these cognitive processes (Hart & Rubia, ), in particular in frontal and parietal regions during executive functions (Carrion, Garrett, Menon, Weems, & Reiss, ; Mueller et al ., ; Philip et al ., ; Raine et al ., ).…”

Impacto do estresse precoce no agravo do transtorno afetivo bipolar em um Centro de Atenção Psicossocial

“…Como mostra na tabela 5. (GOULD et al, 2012;GULEÇ et al, 2013;ARAUJO, 2015;JIMÉNEZ et al, 2017;POLETI et al, 2017). O que condiz com o perfil da amostra analisada no presente estudo e evidencia a relevância e pertinência de estudos nesta temática.…”