Impact of chemical exposure on cancer mortality in a French cohort of uranium processing workers

Zhivin, Sergey; Laurier, Dominique; Caër-Lorho, Sylvaine; Acker, A.; Canu, Irina Guseva

doi:10.1002/ajim.22231

Cited by 11 publications

(6 citation statements)

References 43 publications

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“…Two reports on a cohort of aerospace workers showed workers with a greater hydrazine exposure had an increased risk of death from lung cancer (RR = 1.45;95% CI:0.81–2.39), but that the increased risks were not statistically significant and the upper 95% confidence interval excluded a relative risk of more than 3 [ 6 – 7 ] An earlier study on the same cohort [ 8 ], had found a significant effect, but they had assumed all test stand mechanics were exposed to hydrazine, in the later studies they used a more precise exposure assessment [ 7 ]. A recent study of a French cohort of uranium processing workers also showed a non-significant increased risk of mortality from lung cancer after exposure to hydrazine (RR = 1.21; 95% CI: 0.68–2.17) [ 9 ], Both of these results are not inconsistent with our results.…”

Section: Discussionsupporting

confidence: 74%

Occupational Exposure to Hydrazine and Subsequent Risk of Lung Cancer: 50-Year Follow-Up

2015

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PurposeHydrazine is carcinogenic in animals, but there is inadequate evidence to determine if it is carcinogenic in humans. This study aimed to evaluate the association between hydrazine exposure and the risk of lung cancer.MethodsThe cause specific mortality rates of a cohort of 427 men who were employed at an English factory that produced hydrazine between 1945 and 1971 were compared with national mortality rates.ResultsBy the end of December 2012 205 deaths had occurred. For men in the highest exposure category with greater than two years exposure and after more than ten years since first exposure the relative risks compared with national rates were: 0.85 (95% CI: 0.18–2.48) for lung cancer, 0.61 (95% CI: 0.07–2.21) for cancers of the digestive system, and 0.44 (95% CI: 0.05–1.57) for other cancers.ConclusionsAfter 50 years of follow up, the results provide no evidence of an increased risk of death from lung cancer or death from any other cause.

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Section: Discussionsupporting

confidence: 74%

Occupational Exposure to Hydrazine and Subsequent Risk of Lung Cancer: 50-Year Follow-Up

2015

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“…For example, TCE, as a chlorinated solvent, is a known carcinogen of group 1 according to the International Agency for Research on Cancer (IARC) 23. This exposure was not statistically significantly associated with excess lung and lymphohaematopoietic cancer as observed in our previous study 9. Finally, models were not adjusted for non-radiological exposures, because their simultaneous inclusion in the models produced unstable risk estimates.…”

Section: Discussionmentioning

confidence: 69%

“…Together with ionising radiation, uranium enrichment workers are known to be exposed to numerous non-radiological hazards 9 17 26. While these chemical and physical hazards are present in nuclear fuel cycle activities, they are rarely considered in epidemiological studies.…”

Section: Discussionmentioning

confidence: 99%

“…French nuclear fuel cycle workers are subject to uranium exposure of various physicochemical forms and other chemical and physical hazards9 during the following steps in the fuel cycle: ore milling and refining to produce a uranium concentrate powder known as ‘yellow cake’, conversion to uranium tetrafluoride (UF 4 ) and uranium hexafluoride (UF 6 ), enrichment of isotope 235 U, uranium fuel fabrication and spent fuel reprocessing and disposal. Since exposures to these workers are regularly monitored for the purposes of radiation protection, they represent one of the most pertinent groups for studying health risks associated with chronic radiation exposure 10…”

Section: Introductionmentioning

confidence: 99%

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Mortality (1968–2008) in a French cohort of uranium enrichment workers potentially exposed to rapidly soluble uranium compounds

et al. 2015

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“…At the same time, the risk of developing lung cancer increases in the cases with pre-existing nonmalignant lung deceases such as chronical obstructive lung decease, idiopatic lung fibrose and tuberculosis. A pilot sudy concerning the exposure to the chemical agents in French workers (28) confirms that the exposure to the risk factors multiplies the morbidity caused by lung cancer. The difference in professional distribution in both groups in this study, concerning the health status, was not high enough to be statistically verified.…”

Section: Discussionmentioning

confidence: 86%

Demographic Characteristics of Lung Cancer

Antuleska-Belceska¹,

Petrović²,

Ristic³

et al. 2014

AMM

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Lung cancer worldwide is the most common malignancy in men, whereas in women it ranks second. At the same time the lung cancer is the leading cause of cancerrelated death. Today, smoking is considered as the major cause of lung cancer. About 90% of lung cancers in men and 78 % of lung cancers in women may be associated with long-term smoking.A total of 173 patients with histologically confirmed NSCLC and SCLC were included in this prospective-retrospective study. In the study, all patients were divided into two groups: operable ( 117) and inoperable (56). To quantify the association of certain risk factors and the incidence of lung cancer, an odds ratio (OR) 95 % CI was calculated. To determine the level of significance, the value of p <0.05 was taken, and the value of p <0.01 was taken for high significance.The mean age of the group was 60.2 ± 8.7 years, with the youngest patient in the study group aged 31 and the oldest 75 years. There were 80 pensioners (46.25%) and 59 (34,1%) able-bodied patients in the structure of the socioeconomic status. In regard to smoking status, the majority were smokers. The period of smoking was over 20 years and longer; in regard to intensity of smoking they were divided into three groups: smokers with more than 20 years of smoking experience and more than one pack of cigarettes per day -49.13%, smokers with more than 20 years of smoking experience and one pack of cigarettes per day -5.78%, and smokers who smoke more than 20 years but not continuously -15.61%. Occupational exposure was present in 16.18% of the study population, while positive family history was present in 20.81% of patients. Regarding heredity, applying the Chi-square test, we have shown that heredity has a highly significant correlation with the type of cancer reported in both groups.The demographic characteristics of the test are shown to be statistically significant in relation to lung cancer.

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Impact of chemical exposure on cancer mortality in a French cohort of uranium processing workers

Abstract: Based on our pilot study, it seemed important to take into account chemical exposures in the analyses of cancer mortality among French uranium processing workers.

Cited by 11 publications

References 43 publications

Occupational Exposure to Hydrazine and Subsequent Risk of Lung Cancer: 50-Year Follow-Up

Occupational Exposure to Hydrazine and Subsequent Risk of Lung Cancer: 50-Year Follow-Up

Mortality (1968–2008) in a French cohort of uranium enrichment workers potentially exposed to rapidly soluble uranium compounds

Demographic Characteristics of Lung Cancer

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