Impact of cervical cancer on quality of life of women in Hubei, China

Thapa, Niresh; Maharjan, Muna; Xiong, Yan; Jiang, Daqiong; Nguyen, Thi-Phuong; Petrini, Marcia A.; Cai, Hongwei

doi:10.1038/s41598-018-30506-6

Cited by 51 publications

(92 citation statements)

References 40 publications

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“…Time since completion of treatment has effects on participants' perception of HRQoL. 19 In our study, the pattern of change in GHS was highest at or after 15 years of treatment. The perceived increase in GHS was later when compared to the trend reported in a similar study in China.…”

Section: Discussionmentioning

confidence: 48%

Health-related Quality of Life Among Cervical Cancer Survivors at a Tertiary Hospital in Kumasi, Ghana

Amo‐Antwi

Agambire

Konney

et al. 2020

Preprint

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BackgroundCervical cancer survivors often experience significant diminution in health-related quality of life (HRQoL). We aimed to investigate the overall HRQoL, determine the role of the stage of disease and type of treatment received on HRQoL, and evaluate predictors of HROoL among cervical cancer survivors in Ghana.MethodsA hospital-based cross-sectional study was conducted in 153 cervical cancer patients who completed curative treatment between January 2004 and December 2018 at Komfo Anokye Teaching Hospital. The European Organization for Research and Treatment of Cancer core questionnaire (EORTC QLQ C-30) supplemented with the cervical cancer-specific (EORTC QLQ-CX24) module was used. The Kruskal-Wallis test was used to determine the effect of the stage of cervical cancer and the type of treatment received on mean scores of the different domains of HRQoL. Multivariate logistic regression was performed to identify predictors of HRQoL.ResultsThe mean global health status (GHS) was 79.7 (+/-16.2), and it differed significantly with FIGO stage, with 84.1 76.2, and 79.9, for stages I, II and III respectively (p=0.012). Financial burden was higher in participants with FIGO stage II compared to stage I disease (45.4 vs 20.8, p=0.012.). The mean GHS scores for surgery, chemoradiation and radiation only were 85.2, 75.9, and 82.1 respectively (p=0.027). Compared to participants who were treated with Chemoradiation, those treated with surgery had lower financial difficulties (12.1 vs 41.6 , p=0.019), better body image (95.7vs 79.5, p =0.039) and better symptom experience (5.9 vs 12.0, p =0.043).The likelihood that survivors’ HQROL is affected is decreased with illiteracy (AOR = 0.30, 95% CI=0.09–1.00), and increased with complaints of pain (AOR=5.50, 95%CI=1.68-18.29), loss of appetite (AOR=13.24, 95% CI=2.71– 64.67) and diminution in body image perception (AOR = 6.04, 95% CI=1.67–21.83). ConclusionCervical cancer survivors in Ghana have overall satisfactory HRQoL. Surgical treatment is associated with improved HRQoL and less financial burden. Efforts to enhance HRQoL should also be focused on maximizing survivors’ body image and managing pain and loss of appetite. Educating women about expected impacts on their quality of life, and strategies to manage and mitigate these impacts, is essential.

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Section: Discussionmentioning

confidence: 48%

Health-related Quality of Life Among Cervical Cancer Survivors at a Tertiary Hospital in Kumasi, Ghana

Amo‐Antwi

Agambire

Konney

et al. 2020

Preprint

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“…Meanwhile, financial difficulties have been found to be a significant factor influencing young SCC patients' QoL following adjuvant RT. According to our investigation and the literature, financial difficulties arose not only from work interruption, loss of employment and family income during the primary therapy, but also from the high medical expenses of RT and the lack of health insurance coverage in the developing areas of China 37,38 . Besides, patients in the RT group scored lower on function scales, including their physical and emotional functions.…”

Section: Discussionmentioning

confidence: 90%

The outcomes and quality of life of young patients undergoing adjuvant radiotherapy versus non-radiotherapy following surgery treating early FIGO stage cervical squamous cell cancer in southwestern China

Yang

Yuan

Zeng

et al. 2020

Sci Rep

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Background: The incidence of cervical cancer in young women is rising, and squamous cell carcinoma makes up a great percentage of the histological types. the presence of aggressive pathologic risk factors following patients' primary surgery may warrant the use of adjuvant radiotherapy. it is important to weigh up the risks and benefits of using adjuvant radiotherapy for each young patient so as to maximize their prognosis while minimizing the treatment-related morbidity. Methods: A retrospective study was performed. It consisted of 97 patients under 35 years old who were diagnosed with cervical squamous cell carcinoma and underwent treatment at West china Second University Hospital between December 2009 and January 2014. Five-year follow-up, prognostic risks, long-term radiation toxicity, female sexual function, and quality of life were investigated. Results: Adjuvant radiotherapy did improve the prognosis of young patients with lymph node metastases. However, there were few significant differences in progress-free survival and overall survival for the young patients without lymph node metastases following adjuvant radiotherapy. Besides, young patients who took radiotherapy exhibited greater intestinal dysfunction, more severe lower extremities edema, greater sexual dysfunction, and worse long-term quality of life. conclusion: Young patients with early-stage cervical squamous cell carcinoma without lymph node metastases who have undergone the primary surgery should be counseled in detail before the decision to use adjuvant radiotherapy can be made. the counseling should emphasize not only the benefit that local recurrence rates can be reduced, but also the risks that treatment-related side effects could increase and lower QoL could occur. Thanks to widespread screening and advanced medical treatment, the incidence and the mortality of cervical cancer have been reduced in developed countries 1. However, in the rural developing regions of China, the morbidity of cervical cancer is still high due to the suboptimal medical conditions, making the cervical cancer a major health problem for women 2,3. Recent studies showed that the incidence of cervical cancer in young women is rising and squamous cell carcinoma (SCC) still makes up a great percentage of the histological types 4,5. To our best knowledge, the persistent infection of high-risk human papillomavirus (HPV) is identified as the most critical factor for the development of cervical cancer 6,7. For young women, the squamous-columnar junction of cervix is more vulnerable to HPV infection if she has an early age of active intercourse.

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“…Sexual dysfunction from surgery is mainly due to the shortened vagina, vaginal dryness, decreased libido. However, after radiotherapy, sexual dysfunction is caused by vaginal stenosis which leads to dyspareunia, difficulty in orgasm, a decrease in sexual satisfaction, and changes in body image (Thapa et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Sexual Dysfunction in Carcinoma Cervix: Assessment in Post Treated Cases by LENTSOMA Scale

Shankar

Patil

Luther

et al. 2020

Asian Pac J Cancer Prev

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Treatment for cervical cancer consists of hysterectomy, radiotherapy, chemotherapy and targeted therapy in different combination based on stage at presentation. However, late consequences of such radical treatments are known but not many Indian studies have reported it. Quality of life and impact on sexual health has become an important issue in view of long survival of cervical cancer patients. LENTSOMA scale is one such scale validated for scoring radiotherapy related morbidity. However, there is need for a comprehensive scale covering all aspects of physical and psychological disruptions to provide complete recovery and rehabilitation. The study was prospective and patients who were treated for cervical cancer on follow up were included in this study. A total of 85 patients, who were treated with surgery, radiotherapy, chemotherapy alone or in combination, comprising of stage I to stage IV disease, participated in this study. Findings of this study showed that pain during intercourse and altered sexual life were reported by 32.9% and 25.9% patients respectively whereas 24.7% found it problematic and in 22.3% patients, alteration in interest in sex were reported. Vaginal stenosis was seen in 75.29% of patients after treatment with decreased frequency of intercourse after treatment was seen in 16.4 % of patients. Combination of surgery and radiotherapy in cervical cancer patients caused more sexual dysfunction and dissatisfaction, especially in lower age group. Treatment morbidity in term of sexual function was more with advanced stage disease and with the patients on longer follow up. Sexual function is an important aspect of quality of life but there is no single self-report measure in routine clinical follow up use which is brief, easy to complete and incorporates all (physical, psychological, emotional) aspects of sexual health for people affected by cancer.

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Impact of cervical cancer on quality of life of women in Hubei, China

Cited by 51 publications

References 40 publications

Health-related Quality of Life Among Cervical Cancer Survivors at a Tertiary Hospital in Kumasi, Ghana

Health-related Quality of Life Among Cervical Cancer Survivors at a Tertiary Hospital in Kumasi, Ghana

The outcomes and quality of life of young patients undergoing adjuvant radiotherapy versus non-radiotherapy following surgery treating early FIGO stage cervical squamous cell cancer in southwestern China

Sexual Dysfunction in Carcinoma Cervix: Assessment in Post Treated Cases by LENTSOMA Scale

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