Impact of Cell-Proliferation-Associated Gene Expression on 2-Deoxy-2-[18F]fluoro-d-Glucose (FDG) Kinetics as Measured by Dynamic Positron Emission Tomography (dPET) in Colorectal Tumors

Strauss, Ludwig G.; Koczan, Dirk; Klippel, Sven; Pan, Leyun; Chen, Cheng; Haberkorn, Uwe; Willis, S.; Dimitrakopoulou-Strauß, Antonia

doi:10.1007/s11307-010-0465-z

Cited by 14 publications

(8 citation statements)

References 19 publications

(23 reference statements)

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“…The improved biodistribution pattern of MH 18 F over 18 FDG is due to the exclusive expression of maltohexaose transporters in bacteria in contrast to the high expression of glucose transporters in mammalian cells. [12c, 24] This allowed MH 18 F to clear from all of the major organs including heart, lung, brain, liver, bone and muscle, whereas 18 FDG had significant accumulation within these tissues. For example, in infected rats, the ratio of accumulation of MH 18 F in infected muscle versus liver was 5, whereas for 18 FDG, this ratio was only 0.3, and for other reported PET contrast agents the infected muscle to liver ratio is also generally less than 1.…”

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confidence: 99%

PET Imaging of Bacterial Infections with Fluorine‐18‐Labeled Maltohexaose

et al. 2014

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A new positron emission tomography (PET) tracer, composed of 18F labeled maltohexaose (MH18F), can image bacteria in vivo with a sensitivity and specificity that is orders of magnitude better than fluorodeoxyglucose (18FDG). MH18F can detect early stage infections composed of as few as 105 E.coli colony forming units (CFUs), and can identify drug resistance in bacteria in vivo. MH18F has the potential to improve the diagnosis of bacterial infections given its unique combination of high specificity and sensitivity for bacteria.

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confidence: 99%

PET Imaging of Bacterial Infections with Fluorine‐18‐Labeled Maltohexaose

et al. 2014

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“…Actually it can be expected that inhibitors of the cell cycle usually reveal a negative correlation to PET parameters. Based on our results in colorectal carcinoma, we were able to show that cdki 2B was negatively correlated with k3 [5]. In contrast, cdk2 was positively correlated with the SUV in these tumors.…”

Section: Discussionmentioning

confidence: 94%

“…The tracer kinetics of FDG is closely dependent on the expression of glucose transporters and hexokinases. However, it was shown that the kinetics of FDG may be modulated by genes associated with angiogenesis and proliferation [4, 5]. Thus, gene expression may be predicted from a detailed analysis of the FDG kinetics in certain tumors.…”

Section: Introductionmentioning

confidence: 99%

Correlation of Dynamic PET and Gene Array Data in Patients with Gastrointestinal Stromal Tumors

Strauss

Dimitrakopoulou-Strauß

Koczan

et al. 2012

The Scientific World Journal

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Introduction. The results obtained with dynamic PET (dPET) were compared to gene expression data obtained in patients with gastrointestinal stromal tumors (GIST). The primary aim was to assess the association of the dPET results and gene expression data. Material and Methods. dPET was performed following the injection of F-18-fluorodeoxyglucose (FDG) in 22 patients with GIST. All patients were examined prior to surgery for staging purpose. Compartment and noncompartment models were used for the quantitative evaluation of the dPET examinations. Gene array data were based on tumor specimen obtained by surgery after the PET examinations. Results. The data analysis revealed significant correlations for the dPET parameters and the expression of zinc finger genes (znf43, znf85, znf91, znf189). Furthermore, the transport of FDG (k1) was associated with VEGF-A. The cell cycle gene cyclin-dependent kinase inhibitor 1C was correlated with the maximum tracer uptake (SUVmax) in the tumors. Conclusions. The data demonstrate a dependency of the tracer kinetics on genes associated with prognosis in GIST. Furthermore, angiogenesis and cell proliferation have an impact on the tracer uptake.

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“…They found that the kinetic model in particular k 1 was correlated with the expression of the angiogenesis-related genes. In the same topic and more recently Strauss et al [54] showed in their study on 25 patients that FDG kinetics model in particular the parameters for the transport ( k 1 ) was related with the genes of proliferation, which means that the biological behaviour including angiogenesis and cellular proliferation may be predicted in the light of kinetic data.…”

Section: Kinetic Analysis Of Pet Imaging In Colorectal Tumoursmentioning

confidence: 97%

The Potential Benefit by Application of Kinetic Analysis of PET in the Clinical Oncology

Takesh

2012

ISRN Oncology

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PET is an appropriate method to display the functional activities in target tissue using many types of traces. The visual assessment of PET images plus the semiquantitative parameter (SUV) are the main diagnostic standards considered in identifying the malignant lesion. However, these standards lack occasionally the proper specificity and/or sensitivity. That emphasizes the importance of considering supplemental diagnostic criteria such as the kinetic parameter. The latter gives the way to image the ongoing metabolic processes within the target tissue as well as to identify the alterations occurring at the microscale level before they become observable in the conventional PET-imaging. The importance of kinetic analysis of PET imaging has increased with newly developed PET devices that offer images of good quality and high spatial resolution. In this paper, we highlighted the potential contribution of kinetic analysis in improving the diagnostic accuracy in intracranial tumour, lung tumour, liver tumour, colorectal tumour, bone and soft tissue tumours, and prostate cancer. Moreover, we showed that the appropriate therapy monitoring can be best achieved after considering the kinetic parameters. These promising results indicate that the kinetic analysis of PET imaging may become an essential part in preclinical and clinical molecular imaging as well.

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Impact of Cell-Proliferation-Associated Gene Expression on 2-Deoxy-2-[18F]fluoro-d-Glucose (FDG) Kinetics as Measured by Dynamic Positron Emission Tomography (dPET) in Colorectal Tumors

Cited by 14 publications

References 19 publications

PET Imaging of Bacterial Infections with Fluorine‐18‐Labeled Maltohexaose

PET Imaging of Bacterial Infections with Fluorine‐18‐Labeled Maltohexaose

Correlation of Dynamic PET and Gene Array Data in Patients with Gastrointestinal Stromal Tumors

The Potential Benefit by Application of Kinetic Analysis of PET in the Clinical Oncology

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