Impact of Cardiovascular Risk Factors on Arterial Stiffness in a Countryside Area of Switzerland: Insights from the Swiss Longitudinal Cohort Study

Pusterla, Lucrezia; Radovanović, Dragana; Muggli, Franco; Erné, Paul; Schoenenberger, Andreas W.; Schoenenberger-Berzins, Renate; Parati, Gianfranco; Suter, Paolo M.; Lava, Sebastiano A. G.; Gallino, Augusto; Bianchetti, Mario G.

doi:10.1007/s40119-022-00280-8

Cited by 3 publications

(3 citation statements)

References 33 publications

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“…However, both men and women are at risk for adult-onset hypertension, and studies should enlighten whether sex is an essential variable for adult-onset hypertension in preterm adults. Interestingly, a recent study found that pulse-wave velocity, with advancing age, may behave differentially in women as compared to men [ 48 ].…”

Section: Adult-onset Hypertensionmentioning

confidence: 99%

Cardiovascular Morbidities in Adults Born Preterm: Getting to the Heart of the Matter!

Kumar

2022

Children

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Advances in perinatal and neonatal care have led to improved survival of preterm infants into adulthood. However, the shift in focus to long-term health in adults born preterm requires a clear understanding of the impact of prematurity on developing organ systems and the development of adult-oriented disease. A less well-recognized area of risk for surviving preterm infants is their cardiometabolic health. Epidemiologic evidence has linked preterm birth to the development of systemic hypertension, type 2 diabetes, metabolic syndrome, heart failure, and ischemic heart disease. Of more significant concern is that the risk of cardiometabolic disorders is higher in adults born preterm compared to full-term infants. The interconnected nature of the cardio-pulmonary system means worsening morbidity and mortality in adults born preterm. Addressing the problems of adults born preterm holistically would help promote cardiovascular health, wellness, and quality of life over their lifetime. Recognizing that adults born preterm are a unique subset of the population is a challenge in the current healthcare environment. Addressing issues relevant to adults born preterm in the clinically and research domain, using technology to characterize cardiopulmonary physiology and exercise tolerance, developing screening tools for early diagnosis and treatment, and robust follow-up of these infants with access to longitudinal data would improve both the quality and longevity of life in adults born preterm.

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Section: Adult-onset Hypertensionmentioning

confidence: 99%

Cardiovascular Morbidities in Adults Born Preterm: Getting to the Heart of the Matter!

Kumar

2022

Children

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“…Additionally, for a given cardiac output, mean BP (MBP) is determined by the systemic vascular resistance, which is predominantly controlled by the peripheral small arteries. On the other hand, for a given stroke volume, pressure fluctuations in the arterial tree are determined by arterial compliance, which is primarily influenced by the aorta and the larger arteries [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Non-Invasive Estimation of Central Systolic Blood Pressure by Radial Tonometry: A Simplified Approach

Chemla

Agnoletti

Jozwiak

et al. 2023

JPM

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Backround. Central systolic blood pressure (cSBP) provides valuable clinical and physiological information. A recent invasive study showed that cSBP can be reliably estimated from mean (MBP) and diastolic (DBP) blood pressure. In this non-invasive study, we compared cSBP calculated using a Direct Central Blood Pressure estimation (DCBP = MBP2/DBP) with cSBP estimated by radial tonometry. Methods. Consecutive patients referred for cardiovascular assessment and prevention were prospectively included. Using applanation tonometry with SphygmoCor device, cSBP was estimated using an inbuilt generalized transfer function derived from radial pressure waveform, which was calibrated to oscillometric brachial SBP and DBP. The time-averaged MBP was calculated from the radial pulse waveform. The minimum acceptable error (DCBP-cSBP) was set at ≤5 (mean) and ≤8 mmHg (SD). Results. We included 160 patients (58 years, 54%men). The cSBP was 123.1 ± 18.3 mmHg (range 86–181 mmHg). The (DCBP-cSBP) error was −1.4 ± 4.9 mmHg. There was a linear relationship between cSBP and DCBP (R2 = 0.93). Forty-seven patients (29%) had cSBP values ≥ 130 mmHg, and a DCBP value > 126 mmHg exhibited a sensitivity of 91.5% and specificity of 94.7% in discriminating this threshold (Youden index = 0.86; AUC = 0.965). Conclusions. Using the DCBP formula, radial tonometry allows for the robust estimation of cSBP without the need for a generalized transfer function. This finding may have implications for risk stratification.

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“…Classical risk factors such as overweight and obesity, high blood pressure, dyslipidemia, hyperuricemia, impaired kidney function, high sodium consumption, and smoking, among others are associated with increased arterial stiffness, which contributes to cardiovascular morbidity and mortality. [7][8][9] Diabetes, another important condition with multiple known effects on the vascular system, is directly linked to the risk of developing cardiovascular diseases. 10 Endothelial dysfunction is a feature usually found in patients with diabetes, with impaired endothelium vasodilator responses, which contribute to increased blood pressure.…”

Section: Introductionmentioning

confidence: 99%

Fasting Glucose, Glycated Hemoglobin, and 2h Post-load Blood Glucose Are Independently Associated With Arterial Stiffness in Diabetes: The ELSA-Brasil Study

et al. 2023

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The association of diabetes with increased large artery stiffness is not definitively established. We aimed to describe the carotid-femoral pulse wave velocity (cf-PWV) in participants with and without diabetes and whether the cf-PWV could vary among the different laboratory-based criteria used. A cross-sectional analysis using baseline data from 13,912 adults was used. cf-PWV as well as anthropometric, biochemical, and clinical data were measured. Diabetes was defined by previous medical diagnosis, medication use, fasting glucose, an oral glucose tolerance test (GTT), or glycated hemoglobin (HbA1c). The prevalence of diabetes was 18.7%, higher in men than in women. After adjustment, participants with diabetes showed higher cf-PWV (men: 9.7 ± 1.7 vs 9.4 ± 1.7 m/s, P < .05; women: 9.4 ± 1.6 vs 9.1 ± 1.7 m/s, P < .05). We observed a progressive increase in cf-PWV as >1 laboratory-based criterion for diabetes diagnosis was reached. Also, participants with diabetes with alterations in any laboratory-based criteria had higher cf-PWV than participants without diabetes, regardless of sex. In summary, diabetes is associated with higher cf-PWV as is each laboratory-based parameter used for its diagnosis. These results support the strong consequences of glucose dysregulation on the vascular system and provide evidence to screen all parameters involved in glycemic metabolism to improve vascular health.

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Impact of Cardiovascular Risk Factors on Arterial Stiffness in a Countryside Area of Switzerland: Insights from the Swiss Longitudinal Cohort Study

Cited by 3 publications

References 33 publications

Cardiovascular Morbidities in Adults Born Preterm: Getting to the Heart of the Matter!

Cardiovascular Morbidities in Adults Born Preterm: Getting to the Heart of the Matter!

Non-Invasive Estimation of Central Systolic Blood Pressure by Radial Tonometry: A Simplified Approach

Fasting Glucose, Glycated Hemoglobin, and 2h Post-load Blood Glucose Are Independently Associated With Arterial Stiffness in Diabetes: The ELSA-Brasil Study

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