Impact of cardiovascular risk factor on the prevalence and severity of symptomatic full-thickness rotator cuff tears

Djerbi, I.; Chammas, Michel; Mirous, Marie-Pierre; Lazerges, Cyril; Coulet, Bertrand

doi:10.1016/j.otsr.2015.06.011

Cited by 47 publications

(61 citation statements)

References 17 publications

(20 reference statements)

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“…Patients with rotator cuff tears had a higher prevalence of hypercholesterolaemia (p=0.02), increased triglyceride levels (p=0.02) and increased LDL levels (p=0.03) than patients without rotator cuff tears 6. Djerbi et al 14 noted that patients with dyslipidaemia had significantly higher odds of rotator cuff tears, independent of all other variables (OR 4.9, p<0.00001). In a large longitudinal, population-based study involving 498 678 participants, 26 664 patients developed rotator cuff disease and hyperlipidaemia was identified as an independent risk factor for developing rotator cuff disease (HR=1.48, p<0.0001) 21…”

Section: Resultsmentioning

confidence: 96%

“…The association between the presence of dyslipidaemia and increased severity of tears was evaluated by Djerbi et al 14. Tears were classified as ‘severe’ if they were massive and involved more than one rotator cuff tendon.…”

Section: Resultsmentioning

confidence: 99%

“…Given the prevalence of lipid disorders, such knowledge may play an important role in the prevention and management of rotator cuff disease, patient selection and the management of expectations 14. Therefore, the purpose of this systematic review was to (1) present the current available evidence on the relationship between lipid disorders and rotator cuff diseases, (2) report the implications of lipid disorders on surgical management and postoperative healing and (3) identify future directions or areas of research.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dyslipidaemia is associated with an increased risk of rotator cuff disease: a systematic review

et al. 2017

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Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dyslipidaemia is associated with an increased risk of rotator cuff disease: a systematic review

et al. 2017

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“…The diagnosis becomes more clear by eliminating other factors that can cause this disease2 ) . The primary radiological imaging technique is x-ray3 ) . The clinical examination is able to define rotator cuff tears with either magnetic resonance imaging (MRI) or ultrasonography (US).…”

Section: Introductionmentioning

confidence: 99%

“…Two theories have been proposed to define these factors: intrinsic and extrinsic factors. Recent studies indicate a correlation between intrinsic factors (such as smoking, hypertension, obesity, cardiovascular diseases) and disease prevalence in RCTD3 ) .…”

Section: Introductionmentioning

confidence: 99%

Clinical features of patients diagnosed with degenerative rotator cuff tendon disease: a 6-month prospective-definitive clinical study from turkey

et al. 2017

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[Purpose] In rotator cuff tendon disease (RCTD), anamnesis is as important as clinical findings and anatomic/radio diagnostic examination. This study aimed to investigate the clinical features of patients diagnosed with RCTD using clinical and radiological methods between March 2015 and August 2015 at Malatya Research and Training Hospital Physical Medicine and Rehabilitation department. [Subjects and Methods] The study included 178 patients who were diagnosed with RCTD (128 females and 50 males). A questionnaire comprising 33 questions was given to each patient. [Results] Eighty-eight of the patients (49.9%) had an involvement on their right side, eighty-four (47.1%) had an involvement on their left side, and 6 had bilateral involvement. Mean visual analog scale (VAS) score was found to be statistically significant in favor of female patients. A statistically significant correlation was found between educational status and VAS. The body mass index (BMI) of the female patients was found to be higher than that of the male patients. Statistically significant correlation between doing risky work and gender showed that males were at a higher risk. [Conclusion] RCDT is more seen in people who have high BMI and are at their 50s. Pain complaint and BMI were found higher in female patients. DM, thyroid and cardiac diseases were seen more in the patients who are diagnosed with RCTD relative to the healthy population.

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Factors associated with genetic markers for rotator cuff disease in patients with atraumatic rotator cuff tears

Yanik,

Saccone,

Aleem

et al. 2023

Journal Orthopaedic Research

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For atraumatic rotator cuff tears, genetics contributes to symptomatic tear risk and may influence rotator cuff healing after surgical repair. But little is known about how genetic factors influence rotator cuff tear patient characteristics at presentation. We collected saliva samples for genotyping from atraumatic rotator cuff tear patients. We examined nine single nucleotide polymorphisms (SNPs) associated with cuff tears in prior literature. We estimated associations of SNP dosage with (1) age at tear diagnosis, (2) bilateral atraumatic tear prevalence, and (3) tear size. Linear regression was used to estimate associations with diagnosis age adjusted for sex and principal components. Logistic regression and ordinal logistic regression were used to estimate associations with bilateral tear prevalence and tear size category, respectively, adjusting for age, sex, and principal components. Of 344 eligible patients, 336 provided sufficient samples for genotyping. Median age at tear diagnosis was 61, 22% (N = 74) had bilateral atraumatic tears, and 9% (N = 29) had massive tears. SNP rs13107325 in the SLC39A8 gene and rs11850957 in the STXBP6 gene were associated with younger diagnosis age even after accounting for multiple comparisons (rs13107325: −4 years, 95% CI = −6.5, −1.4; rs11850957: −2.7 years, 95% CI = −4.3, −1.1). No other significant associations were observed with diagnosis age, tear size, or bilateral tear prevalence. SLC39A8 encodes a Mn transporter. STXBP6 may play a role in inflammatory responses by altering phagocytosis and antigen presentation of monocytes and macrophages. Further research is needed to determine if genetic markers can be used alongside patient characteristics to aid in identifying optimal surgical repair candidates.

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Impact of cardiovascular risk factor on the prevalence and severity of symptomatic full-thickness rotator cuff tears

Cited by 47 publications

References 17 publications

Dyslipidaemia is associated with an increased risk of rotator cuff disease: a systematic review

Dyslipidaemia is associated with an increased risk of rotator cuff disease: a systematic review

Clinical features of patients diagnosed with degenerative rotator cuff tendon disease: a 6-month prospective-definitive clinical study from turkey

Factors associated with genetic markers for rotator cuff disease in patients with atraumatic rotator cuff tears

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