Impact of cardiovascular comorbidities on inpatient mortality in patients hospitalized with neutropenic fever

Atallah‐Yunes, Suheil Albert; Kadado, Anis John; Haddadin, Faris; Sawalha, Khalid; Hernández-Montfort, Jaime; Ali, Syed Sohail

doi:10.1007/s00520-020-05518-6

Support Care Cancer

2020

DOI: 10.1007/s00520-020-05518-6

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Impact of cardiovascular comorbidities on inpatient mortality in patients hospitalized with neutropenic fever

Suheil Albert Atallah‐Yunes

Anis John Kadado

Faris Haddadin

et al.

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Cited by 2 publications

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“…ebrile neutropenia is a serious complication in patients receiving chemotherapy and is one of the most common causes of hospitalization in this population. 1 This condition is considered an oncologic emergency, and if not addressed in a timely manner, it may progress to multiorgan system failure and may be fatal. Studies have shown that among patients who have neutropenic fever treated with empirical antibiotics, mortality rates range from 4% to 20%; among those who aren't treated with antibiotics, the mortality rate can be as high as 70%.…”

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CE: Febrile Neutropenia in the Chemotherapy Patient

Foley

Hoffman

2023

AJN, American Journal of Nursing

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Febrile neutropenia is a serious complication of chemotherapy treatment and may present as the only clinical sign of infection. If not addressed in a timely manner, it may progress to multisystem organ failure and may be fatal. Initial assessment of fever in those receiving chemotherapy requires prompt administration of antibiotics, ideally within one hour of presentation. Depending on the clinical status of the patient, antibiotic treatment may occur in the inpatient or outpatient setting. Nurses play an important role in the identification and treatment of patients at high risk for febrile neutropenia through assessment and adherence to clinical practice guidelines. In addition, nurses play an active role in patient education regarding risk factors, protective measures, and signs and symptoms of infection in the immunocompromised oncology patient.

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confidence: 99%

“…Febrile neutropenia is a serious complication in patients receiving chemotherapy and is one of the most common causes of hospitalization in this population 1. This condition is considered an oncologic emergency, and if not addressed in a timely manner, it may progress to multiorgan system failure and may be fatal.…”

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confidence: 99%

CE: Febrile Neutropenia in the Chemotherapy Patient

Foley

Hoffman

2023

AJN, American Journal of Nursing

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Delay in Time to Antibiotics for De Novo Inpatient Neutropenic Fever May Not Impact Overall Survival for Patients With a Cancer Diagnosis

Villars

Gardner

Binder

2022

American Journal of Medical Quality

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Neutropenic fever (NF) is an oncologic emergency for which expert consensus recommends that anti-pseudomonas antibiotics be administered within 60 minutes of detection. This study investigated whether delays in time to antibiotics (TTA) impacted overall survival (OS) for patients with hematological malignancies who developed inpatient NF via a retrospective cohort study of 187 de novo NF cases categorized by TTA (<1, 1–2, 2–3, 3–4 and >4 hours). OS at 180 days post-NF episode was compared using Kaplan-Meier estimates and multivariable Cox proportional hazards model. TTA did not significantly affect OS (P = 0.420). Patients with Charleston Comorbidity Indexes ≥3, a measure of overall health, had higher hazard (hazard ratio [HR] = 2.728, 95% confidence interval, 1.265-5.882, P = 0.010). TTA delays in the hospital may not be long enough to cause significant patient harm. Larger studies may be needed to detect small, but significant mortality differences.

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Impact of cardiovascular comorbidities on inpatient mortality in patients hospitalized with neutropenic fever

Cited by 2 publications

References 20 publications

CE: Febrile Neutropenia in the Chemotherapy Patient

CE: Febrile Neutropenia in the Chemotherapy Patient

Delay in Time to Antibiotics for De Novo Inpatient Neutropenic Fever May Not Impact Overall Survival for Patients With a Cancer Diagnosis

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