Impact of cardiac magnetic resonance imaging on human lymphocyte DNA integrity

Fiechter, Michael; Stehli, Julia; Fuchs, Tobias A.; Dougoud, Svetlana; Gaemperli, Oliver; Kaufmann, Philipp A.

doi:10.1093/eurheartj/eht184

Cited by 81 publications

(67 citation statements)

References 30 publications

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“…We also reported, for the first time, the dynamic evolution of DNA damage over long-time periods (≤1 month). Fiechter et al 11 showed significant DNA damage in patient T lymphocytes as soon as 1 or 2 hours post contrast enhanced CMR. …”

Section: Cmr Scanning and Dna Damage Of Circulating Lymphocytesmentioning

confidence: 98%

“…[11][12][13][14] We showed that γ-H2AX intensity in NK cells could be a more sensitive marker than T lymphocytes to evaluate early CMR-induced DNA damage. We also reported, for the first time, the dynamic evolution of DNA damage over long-time periods (≤1 month).…”

Section: Cmr Scanning and Dna Damage Of Circulating Lymphocytesmentioning

confidence: 99%

“…9,10 Several studies reported an immediate post-MRI increase of histone H2AX phosphorylation (γ-H2AX) in lymphocytes, a marker of DNA double-strand breaks, in a magnitude comparable with damages produced by low-dose ionizing radiation. [11][12][13] Whether MRI-induced DNA damage can persist or evolve over time is unknown. In this study, we sought to evaluate the early and late biological responses of blood cells (DNA double-strand breaks, cell count, cell death, and cell activation) to CMR in normal subjects.…”

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confidence: 99%

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Biological Effects of Cardiac Magnetic Resonance on Human Blood Cells

Lancellotti

Nchimi

Delierneux

et al. 2015

Circ: Cardiovascular Imaging

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The study was approved by the local Institutional Human Research Committee and conducted according to the ethical guidelines and principles of the international Helsinki declaration. After informed consent, 20 healthy male subjects ≥20 years (31.4±7.9 years) with normal physical cardiac examination (with no systolic nor diastolic murmur), normal ECG, without history of any cardiovascular disease or history of current smoking, no chronic excessive alcohol consumption, not currently on medical therapy with cardio-active drugs were prospectively recruited. Every volunteer was asked not to practice Background-Cardiac magnetic resonance (CMR) is increasingly used for the diagnosis and management of cardiac diseases. Recent studies have reported immediate post-CMR DNA double-strand breaks in T lymphocytes. We sought to evaluate CMR-induced DNA damage in lymphocytes, alterations of blood cells, and their temporal persistence. Methods and Results-In 20 prospectively enrolled healthy men (31.4±7.9 years), blood was drawn before and after (1-2 hours, 2 days, 1 month, and 1 year) unenhanced 1.5T CMR. Blood cell counts, cell death, and activation status of lymphocytes, monocytes, neutrophils, and platelets were evaluated. The first 2-hour post-CMR were characterized by a small increase of lymphocyte B and neutrophil counts and a transient drop of total lymphocytes because of a decrease in natural killer cells. Among blood cells, only neutrophils and monocytes displayed slight and transient activation.DNA double-strand breaks in lymphocytes were quantified through flow cytometric analysis of H2AX phosphorylation (γ-H2AX). γ-H2AX intensity in T lymphocytes did not change early after CMR but increased significantly at day 2 ≤1 month before returning to baseline levels of 1-year post-CMR. Conclusions-Unenhanced CMR is associated with minor but significant immediate blood cell alterations or activations figuring inflammatory response, as well as DNA damage in T lymphocytes observed from day 2 until the first month but disappearing at 1-year follow-up. Although further studies are required to definitely state whether CMR can be used safely, our findings already call for caution when it comes to repeat this examination within a month. (Circ Cardiovasc Imaging. 2015;8:e003697.

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Section: Cmr Scanning and Dna Damage Of Circulating Lymphocytesmentioning

confidence: 98%

Section: Cmr Scanning and Dna Damage Of Circulating Lymphocytesmentioning

confidence: 99%

mentioning

confidence: 99%

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Biological Effects of Cardiac Magnetic Resonance on Human Blood Cells

Lancellotti

Nchimi

Delierneux

et al. 2015

Circ: Cardiovascular Imaging

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“…This would support why the authors found a delay between CMR exposure and DNA damage. The authors suggest that previous studies had found a somewhat earlier increase in DSB because patients were also exposed to gadolinium, 3,23 which has been shown to potentiate the genotoxic effect of CMR 30 but still requires some delay after CMR exposure.…”

Section: See Article By Lancellotti Et Almentioning

confidence: 90%

Cardiac Magnetic Resonance Imaging

Kaufmann

2015

Circ: Cardiovascular Imaging

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“…However, some genotoxic effects of MRI scanning have been demonstrated under in vivo as well as in vitro conditions (Suzuki et al, 2001;Simi et al, 2008;Lee et al, 2011;Fiechter et al 2013). A recent review on safety of MRI has recommended a need for further studies as a precautionary principle (Hartwig et al, 2009).…”

Section: Genotoxic Effectsmentioning

confidence: 99%