Impact of carbamylation and glycation of collagen type I on migration of HT1080 human fibrosarcoma cells

Said, Georges; Guilbert, Marie; Millerot-Serrurot, Emilie; Gulick, Laurence Van; Terryn, Christine; Garnotel, Roselyne; Jeannesson, Pierre

doi:10.3892/ijo.2012.1393

Cited by 11 publications

(9 citation statements)

References 27 publications

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“… Carbamylation Collagen Non-enzymatic Currently poorly understood Increased carbamylation decreases stability of collagen I triple helices and affects their degradation by MMPs 273 . Carbamylated collagen type I affects cancer cell migration 274 . Glycation Collagen Non-enzymatic Currently poorly understood Glycated collagen type I affects cancer cell migration 274 .…”

Section: Mechanisms Of Tumourigenic Ecm Remodellingmentioning

confidence: 99%

Concepts of extracellular matrix remodelling in tumour progression and metastasis

et al. 2020

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Tissues are dynamically shaped by bidirectional communication between resident cells and the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling. Tumours leverage ECM remodelling to create a microenvironment that promotes tumourigenesis and metastasis. In this review, we focus on how tumour and tumour-associated stromal cells deposit, biochemically and biophysically modify, and degrade tumour-associated ECM. These tumour-driven changes support tumour growth, increase migration of tumour cells, and remodel the ECM in distant organs to allow for metastatic progression. A better understanding of the underlying mechanisms of tumourigenic ECM remodelling is crucial for developing therapeutic treatments for patients.

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Section: Mechanisms Of Tumourigenic Ecm Remodellingmentioning

confidence: 99%

Concepts of extracellular matrix remodelling in tumour progression and metastasis

et al. 2020

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“…Collagen is a major component of the ECM and is a prominent target of non-enzymatic glycation [53]. This protein is the longest living protein in higher animals, where it occurs primarily as extracellular, insoluble fibers.…”

Section: Glycation Of Collagenmentioning

confidence: 99%

“…Studies showed that glycated collagen alters the endothelial cell function and could be an important factor in atherosclerotic plaque development [58]. In vivo, collagen glycation may affect tumor cell metastasis [53]. Recent study reported that arteriosclerosis results from glycation of collagen chains in muscular-type arterioles as glyoxal and MGO form cross-links between collagen fibers [59].…”

Section: Glycation Of Collagenmentioning

confidence: 99%

Advanced Glycation End Products and Diabetic Complications

Singh

Bali

Singh

et al. 2014

Korean J Physiol Pharmacol

1,153

794

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During long standing hyperglycaemic state in diabetes mellitus, glucose forms covalent adducts with the plasma proteins through a non-enzymatic process known as glycation. Protein glycation and formation of advanced glycation end products (AGEs) play an important role in the pathogenesis of diabetic complications like retinopathy, nephropathy, neuropathy, cardiomyopathy along with some other diseases such as rheumatoid arthritis, osteoporosis and aging. Glycation of proteins interferes with their normal functions by disrupting molecular conformation, altering enzymatic activity, and interfering with receptor functioning. AGEs form intra- and extracellular cross linking not only with proteins, but with some other endogenous key molecules including lipids and nucleic acids to contribute in the development of diabetic complications. Recent studies suggest that AGEs interact with plasma membrane localized receptors for AGEs (RAGE) to alter intracellular signaling, gene expression, release of pro-inflammatory molecules and free radicals. The present review discusses the glycation of plasma proteins such as albumin, fibrinogen, globulins and collagen to form different types of AGEs. Furthermore, the role of AGEs in the pathogenesis of diabetic complications including retinopathy, cataract, neuropathy, nephropathy and cardiomyopathy is also discussed.

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“…Due to its longevity, it constitutes a prominent target of structural modifications usually associated with various physiological processes, such as diabetes, renal diseases, aging, and cancer. 181 THG occurs even in centrosymmetric structures and can visualize interface heterogeneities as well as myelin sheaths in studies of the nervous system in animal models. 182 Since SHG and THG do not excite coupling of electronic levels, photobleaching can be suppressed, enabling observation of structures over extended periods.…”

Section: Multimodal Oct and Mpmmentioning

confidence: 99%

Optical coherence tomography today: speed, contrast, and multimodality

Drexler¹,

Li²,

Kumar³

et al. 2014

J. Biomed. Opt

419

264

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Abstract. In the last 25 years, optical coherence tomography (OCT) has advanced to be one of the most innovative and most successful translational optical imaging techniques, achieving substantial economic impact as well as clinical acceptance. This is largely owing to the resolution improvements by a factor of 10 to the submicron regime and to the imaging speed increase by more than half a million times to more than 5 million A-scans per second, with the latter one accomplished by the state-of-the-art swept source laser technologies that are reviewed in this article. In addition, parallelization of OCT detection, such as line-field and full-field OCT, has shortened the acquisition time even further by establishing quasi-akinetic scanning. Besides the technical improvements, several functional and contrast-enhancing OCT applications have been investigated, among which the label-free angiography shows great potential for future studies. Finally, various multimodal imaging modalities with OCT incorporated are reviewed, in that these multimodal implementations can synergistically compensate for the fundamental limitations of OCT when it is used alone. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Impact of carbamylation and glycation of collagen type I on migration of HT1080 human fibrosarcoma cells

Cited by 11 publications

References 27 publications

Concepts of extracellular matrix remodelling in tumour progression and metastasis

Concepts of extracellular matrix remodelling in tumour progression and metastasis

Advanced Glycation End Products and Diabetic Complications

Optical coherence tomography today: speed, contrast, and multimodality

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