Impact of cancer cachexia on respiratory muscle function and the therapeutic potential of exercise

Murphy, Ben T.; Mackrill, John J.; O’Halloran, Ken D.

doi:10.1113/jp283569

Cited by 6 publications

(3 citation statements)

References 233 publications

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“…Numerous studies have explored the impact of exercise on cancer cachexia, ranging from preclinical models to clinical trials. 43 , 44 These studies demonstrate promising findings, substantiated by this review, indicating that exercise can attenuate muscle wasting, improve physical function, and enhance overall well-being in cancer patients. 45 Although the literature in this field is growing, the limited evidence base is acknowledged by international guidelines.…”

Section: Discussionmentioning

confidence: 54%

Exercise-based interventions for cancer cachexia: A systematic review of randomised and non-randomised controlled trials

Cheung,

Boocock,

Grande

et al. 2023

Asia-Pacific Journal of Oncology Nursing

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Section: Discussionmentioning

confidence: 54%

Exercise-based interventions for cancer cachexia: A systematic review of randomised and non-randomised controlled trials

Cheung,

Boocock,

Grande

et al. 2023

Asia-Pacific Journal of Oncology Nursing

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“…The impact of cachexia on respiratory muscle atrophy and function has also been suggested. As is evident in studies concerned with cachexia and limb muscle, elevations in inflammatory factors have also been identified as a contributing mechanism of muscle atrophy and contractile dysfunction in respiratory muscles [35 ▪ ]. However, the extent of research investigating cachexia in the context of its impact on respiratory muscle atrophy and function is scarce; additional research is required to profile diaphragm muscle atrophy and dysfunction in cachexia [35 ▪ ].…”

Section: Respiratory Sarcopenia and Physical And Nutritional Statusmentioning

confidence: 99%

Definition, diagnosis, and treatment of respiratory sarcopenia

Miyazaki,

Tamaki,

Wakabayashi

et al. 2023

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of review Skeletal muscle weakness and wasting also occurs in the respiratory muscles, called respiratory sarcopenia. Respiratory sarcopenia may lead to worse clinical indicators and outcomes. We present a novel definition and diagnostic criteria for respiratory sarcopenia, summarize recent reports on the association between respiratory sarcopenia, physical and nutritional status, and clinical outcomes, and provide suggestions for the prevention and treatment of respiratory sarcopenia. Recent findings Recently, a novel definition and diagnostic criteria for respiratory sarcopenia have been prepared. Respiratory sarcopenia is defined as a condition in which there is both low respiratory muscle strength and low respiratory muscle mass. Respiratory muscle strength, respiratory muscle mass, and appendicular skeletal muscle mass are used to diagnose respiratory sarcopenia. Currently, it is challenging to definitively diagnose respiratory sarcopenia due to the difficulty in accurately determining low respiratory muscle mass. Decreased respiratory muscle strength and respiratory muscle mass are associated with lower physical and nutritional status and poorer clinical outcomes. Exercise interventions, especially respiratory muscle training, nutritional interventions, and their combinations may effectively treat respiratory sarcopenia. Preventive interventions for respiratory sarcopenia are unclear. Summary The novel definition and diagnostic criteria will contribute to promoting the assessment and intervention of respiratory sarcopenia.

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“…Notably, there are some review articles that have summarized the potential beneficial effects of exercise on quality of life, depression, cancer-related cognitive impairment, functionality status, chronic pain, cancer-related fatigue, radiotherapy-related dysphagia, psycho-emotional status, cancer cachexia, sarcopenia, chemotherapy toxicity, bone health, and sleep disturbances [14][15][16][17][18][19][20][21][22][23][24][25][26][27]. However, only a few outdated review articles have focused on the anti-cancer molecular mechanisms of exercise.…”

Section: Introductionmentioning

confidence: 99%

Exercise as a Promising Agent against Cancer: Evaluating Its Anti-Cancer Molecular Mechanisms

Spanoudaki,

Giaginis,

Karafyllaki

et al. 2023

Cancers

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Background: Cancer cases are continuously increasing, while the prevalence rates of physical inactivity are also continuously increasing. Physical inactivity is a causative factor in non-communicable diseases, including cancer. However, the potential beneficial effects of exercise on cancer treatment have not received much attention so far. The aim of this study was to highlight the relationship between cancer and exercise on a molecular basis. Methods: Comprehensive and in-depth research was conducted in the most accurate scientific databases by using relevant and effective keywords. Results: The mechanisms by which exercise may reduce cancer risk and/or progression may include the metabolic profile of hormones, systemic inflammation reduction, insulin sensitivity increase, antioxidant capacity augmentation, the boost to the immune system, and the direct effect on the tumor. There is currently substantial evidence that the effect of exercise may predict a stronger association with cancer and could supplementarily be embedded in cancer clinical practice to improve disease progression and prognosis. Conclusion: The field of this study requires interconnecting the overall knowledge of exercise physiology with cancer biology and cancer clinical oncology to provide the basis for personalized targeting strategies that can be merged with training as a component of a holistic co-treatment approach to optimize cancer healthcare.

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Impact of cancer cachexia on respiratory muscle function and the therapeutic potential of exercise

Abstract: support-information-section).

Cited by 6 publications

References 233 publications

Exercise-based interventions for cancer cachexia: A systematic review of randomised and non-randomised controlled trials

Exercise-based interventions for cancer cachexia: A systematic review of randomised and non-randomised controlled trials

Definition, diagnosis, and treatment of respiratory sarcopenia

Exercise as a Promising Agent against Cancer: Evaluating Its Anti-Cancer Molecular Mechanisms

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