Impact of Caffeine and/or Estrogen Deficiency on Trabecular Bone Area and Healing: A Study in Rats

Bastos, Marta Ferreira; Menezes, Diogo José Barreto de; Bezerra, Joyce Pinho; Braz, Caetlin Kelmy Craneck; Fonseca, Paula Fernanda Silva; Arana-Chavez, Victor E.; Azambuja, Nilton; Duarte, Poliana Mendes

doi:10.11607/jomi.3186

Cited by 7 publications

(1 citation statement)

References 49 publications

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“…Moderate caffeine consumption for healthy adult individuals is normally recognized as up to 400 mg per day or 6 mg/kg in a person weighing 65 kg (Nawrot et al, 2003; Temple et al, 2017). The use of a dosage of 10 mg/100g of animal body weight was used to clarify the effects of excessive consumption of the substance, as used in previous studies (Bezerra et al, 2008; Bezerra et al, 2013; Duarte et al, 2009; Bastos et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Excessive caffeine intake increases bone resorption associated with periapical periodontitis in rats

Dal‐Fabbro¹,

Cosme‐Silva

Capalbo³

et al. 2021

Int Endodontic J

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Aim To evaluate the effect of excessive caffeine intake on the inflammation/resorption processes associated with periapical periodontitis (PP) in rats. Methodology Sixteen Wistar rats were used. Periapical periodontitis was induced in the four first molars in each animal. The animals were arranged into two groups: control (C)—rats with periapical periodontitis; and caffeine (CAF)—rats with periapical periodontitis under caffeine administration protocol. The CAF animals received 10 mg/100 g of body weight/day of caffeine via gavage starting fifteen days before PP induction and continuing for thirty more days until euthanasia. On the 30th day, the animals were euthanized and the jaws removed for microcomputed tomography, histological and immunohistochemical analysis for RANKL, OPG, TRAP, IL‐10, TNF‐⍺ and IL‐1β. The Mann–Whitney test was performed for nonparametric data, and Student's t test was performed for parametric data, using p < .05. Results There was no significant difference in the weight change between the groups. The median score of the inflammatory process was significantly greater in the CAF group (3) compared with the C group (2), p = .0256. Bone resorption was greater in the group consuming caffeine (1.08 ± 0.15 mm3) compared with the C group (0.88 ± 0.10 mm3), p = .0346. The immunolabelling for RANKL, TRAP and IL‐1β was significantly higher in the CAF group when compared to the control, p < .05. No differences were found for the OPG, IL‐10 and TNF‐⍺ immunolabelling. Conclusion Excessive caffeine exposure via gavage in rats was able to exacerbate the volume of periapical bone destruction, and the inflammatory pattern deriving from periapical periodontitis altering the expression of RANKL, IL‐1β and TRAP.

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Section: Discussionmentioning

confidence: 99%

Excessive caffeine intake increases bone resorption associated with periapical periodontitis in rats

Dal‐Fabbro¹,

Cosme‐Silva

Capalbo³

et al. 2021

Int Endodontic J

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Is Impregnation of Xenograft with Caffeine Effective on Bone Healing Rate in Mandibular Defects? A Pilot Histological Animal Study

Samieirad

Mianbandi

Sedigh

et al. 2019

J. Maxillofac. Oral Surg.

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β-Estradiol antagonizes the inhibitory effects of caffeine in BMMSCs via the ERβ-mediated cAMP-dependent PKA pathway

et al. 2018

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Impact of Caffeine and/or Estrogen Deficiency on Trabecular Bone Area and Healing: A Study in Rats

Abstract: Caffeine affected bone healing, while estrogen deficiency mainly affected TBA, but no significant deleterious synergic effects of both conditions were observed.

Cited by 7 publications

References 49 publications

Excessive caffeine intake increases bone resorption associated with periapical periodontitis in rats

Excessive caffeine intake increases bone resorption associated with periapical periodontitis in rats

Is Impregnation of Xenograft with Caffeine Effective on Bone Healing Rate in Mandibular Defects? A Pilot Histological Animal Study

β-Estradiol antagonizes the inhibitory effects of caffeine in BMMSCs via the ERβ-mediated cAMP-dependent PKA pathway

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