Impact of breath-hold technique on incidence of cardiac events in adjuvant left breast cancer irradiation

Mahmoud, Amr A; Sadaka, Emad; Abouegylah, Mohamed; Amin, Sara A.; Elmansy, Hazem; Asal, Mohamed; Köksal, Mümtaz; Gawish, Ahmed

doi:10.1007/s00432-022-04551-8

Cited by 2 publications

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mathematical calculations are used to derive model parameters that factor in clinical outcomes to estimate the risk of tumor relapse or toxicity. Both models condense all patient dosimetric data into DVHs, which may limit their descriptive and predictive power [23]. The study conducted by Utehina et al highlights the potential benefits of using respiratorygated techniques in postoperative radiation therapy for early-stage left-sided breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Tumor Control and Normal Tissue Complication Probabilities in Patients Receiving Comprehensive Nodal Irradiation for Left-Sided Breast Cancer

Flores-Balcázar,

Urías-Arce

2024

Current Oncology

View full text Add to dashboard Cite

Women with left-sided breast cancer receiving adjuvant radiotherapy have increased incidence of cardiac mortality due to ischemic heart disease; to date, no threshold dose for late cardiac/pulmonary morbidity or mortality has been established. We investigated the likelihood of cardiac death and radiation pneumonitis in women with left-sided breast cancer who received comprehensive lymph node irradiation. The differences in dosimetric parameters between free-breathing (FB) and deep inspiration breath hold (DIBH) techniques were also addressed. Based on NTCP calculations, the probability of cardiac death was significantly reduced with the DIBH compared to the FB technique (p < 0.001). The risk of radiation pneumonitis was not clinically significant. There was no difference in coverage between FB and DIBH plans. Doses to healthy structures were significantly lower in DIBH plan than in FB plan for V20, V30, and ipsilateral total lung volume. Inspiratory gating reduces the dose absorbed by the heart without compromising the target range, thus reducing the likelihood of cardiac death.

show abstract

Section: Discussionmentioning

confidence: 99%