Impact of Breast Cancer and Combination Chemotherapy on Oxidative Stress, Hepatic and Cardiac Markers

Amin, Kamal Adel; Mohamed, Basant M.; El-Wakil, Mohamed; Ibrahem, Sanaa Omar

doi:10.4048/jbc.2012.15.3.306

Cited by 37 publications

(41 citation statements)

References 25 publications

(22 reference statements)

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“…An elevated serum LDH enzyme activity is the consequence of increased anaerobic glycolysis in rapidly dividing malignant cells and subsequent cell destruction [18]. Increased level of serum LDH suggests the increase rate of enzyme leakage from mitochondria as a result of doxorubicin-induced toxicity [11]. A study by Basnyat et al [19] reported that elevated serum lipids level increased the risk of cardiovascular disease during BC management by FAC combination.…”

Section: Resultsmentioning

confidence: 99%

“…5-Fluorouracil, doxorubicin, and cyclophosphamide (FAC) is the most common combination of chemotherapy drugs used in breast cancer treatment that is often associated with oxidative stress, hepatotoxicity and cardiotoxicity [11]. Elevated levels of cardiac enzymes LDH and creatine kinase (CK) after FAC treatment is evidence of the cardiotoxic effect of chemotherapy [12].…”

Section: Introductionmentioning

confidence: 99%

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Study of Serum Lactate Dehydrogenase and Gamma-Glutamyl Transpeptidase in Breast Cancer Patients receiving Chemotherapy

Basnyat¹,

Jha²,

Pathak³

et al. 2017

JTLS

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Breast cancer (BC) is the most common type of cancer worldwide, being one of the leading causes of morbidity in the female. In Nepal, it is the second most common type of cancer among women of perimenopausal age group. More than one-quarter of the BC is diagnosed in young Nepalese female, with a familial history of breast cancer, early pregnancy, longer lactation and estrogen exposure, often tumors showing aggressive biological behaviors. Anthracyclines (Doxorubicin) based treatment regime were reported to cause cardiotoxicity by increasing intramyocardial free radical production, lipid alterations and decreasing antioxidant level. Oxidative stress involving cellular reactive oxygen species (ROS) production is widely accepted mechanism, but the molecular basis of chemotherapyinduced organ toxicity remains highly controversial. An increased rate of metabolism and oxidative stress results in rapid turnover of cancer cells that modulates the enzyme level in blood circulation. Serum LDH and GGT level correlate with tumor burden, the metastatic character of BC and intensity of organtoxicity. The aim of our study is to evaluate the serum level of LDH and GGT in BC patients receiving chemotherapy and correlate these enzyme levels with different stages of BC. A total number of 150 subjects were included in the study, comprising 90 histopathologically confirmed 24 to 76 years aged patients of different breast cancer stages, receiving at least 3 cycles of 5-Fluorouracil, Adriamycin, and Cyclophosphamide (FAC) chemotherapy. Sixty age-matched healthy women were enrolled as controls. Blood samples from each were collected after informed consent and analyzed for serum LDH and GGT levels using standard biochemical methods. Data were analyzed using student's paired-T test, Pearson correlation test and ANOVA. Serum LDH and GGT levels were significantly (p < 0.001) increased in BC patients as compared to control group. When all 4 stages of BC were compared to control group, LDH and GGT activities showed a progressive increase from stage I to IV. The study concludes that serum LDH and GGT may be sensitive, specific and profitable biomarkers in early diagnosis of breast cancer, assessing cancer prognosis and response to treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Study of Serum Lactate Dehydrogenase and Gamma-Glutamyl Transpeptidase in Breast Cancer Patients receiving Chemotherapy

Basnyat¹,

Jha²,

Pathak³

et al. 2017

JTLS

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“…The etiology of the breast cancer is multifactorial, and besides genetic predisposition, the most known environmental risk factors (age, obesity, drugs, hormones, etc.) have been linked to the oxidative damage to the breast cells also [3,4].…”

Section: Introductionmentioning

confidence: 99%

Influence of oxidative injury and monitoring of blood plasma by DSC on breast cancer patients

Zapf

Moezzi

Fekecs³

et al. 2015

J Therm Anal Calorim

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Damage caused by oxidative stress is involved in many types of diseases, including breast cancer. Our aim was to detect the oxidative stress parameters and blood plasma changes with differential scanning calorimetry (DSC) in breast cancer patients. The study included 40 adult breast cancer women who were grouped according to tumor diameter, regional lymph node metastases, proliferative activity, receptor status and postoperative chemotherapy. To monitor oxidative stress, malondialdehyde, oxygen free radicals (OFRs), activity of myeloperoxidase (MPO), superoxide dismutase (SOD) and catalase (CAT) were measured. Denaturation of plasma components was detected in Setaram Micro DSC-II calorimeter. The total production of OFRs, the MPO activity and lipidperoxidation were significantly increased in each breast cancer patients considering the tumor size, the metastatic lymph nodes, the proliferation activity and receptor status compared with healthy controls (p \ 0.05). These pro-oxidants were slightly elevated without chemotherapy, but their values were increased significantly in chemotherapy-receiving group. The activity of SOD and CAT was significantly decreased in all groups, and in regard to the chemotherapy, they were changed significantly parallel to the severity of disease. Regarding to both the increased tumor diameter and the increased number of affected lymph nodes, DSC measurements showed a strong relationship between the maximum excess heat capacity (C pmax ) of the blood plasma and the severity of disease. The study demonstrated that oxidative stress is implicated in breast carcinoma and chemotherapy aggravates these changes which confirmed the plasma DSC measurements also.

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“…3 Apart from these, a number of genes, like BRCA1 and BRCA2, and p53 have been linked to breast cancer susceptibility and development. 4 Etiology of breast cancer is multifactorial which includes genetic, environmental, social, demographic and hormonal factors. Evidences are there to prove the occurrence of the disease as a result of increased oxidative stress.…”

mentioning

confidence: 99%

“…Similar observations were also found in the studies conducted by Kasapovic et al, and Prabasheela et al, where the blood levels of catalase and superoxide dismutase were found to decrease that indicated increased activity of the free radicals in the breast cancer patients and decreased level of antioxidants as they are utilized for quenching free radicals. 4,11,12 This study was thus undertaken to assess and compare the oxidative stress in breast cancer patients with age and sex matched controls. Aim was to assess the oxidative stress in breast cancer patients and to compare it with that of healthy controls.…”

mentioning

confidence: 99%

Assessment of oxidative stress in breast cancer patients: a hospital based study

Bhattacharjee

Jogdand

Shinde

et al. 2018

Int J Basic Clin Pharmacol

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Background: Oxidative stress occurs as a result of the disturbance in the balance between the production of reactive oxygen species (free radicals) and antioxidant defenses. This is regarded as a possible etilogical factor in production of breast carcinoma, which is the most cmmon cancer among the females both globally as well as in India. Oxidative stress also plays an important role in progression of cancer breast. This study was conducted to compare the levels of superoxide dismutase (SOD) and malondialdehyde (MDA) in breast cancer patients and normal age matched female participants.Methods: This study was conducted in AVBR Hospital, Sawangi (Meghe) among 30 female breast cancer patients admitted in the surgery ward for treatment after being diagnosed with the disease, who attended the hospital from July 2016 to June 2017. Breast cancer patients of stage I and II were included in the study. Patients suffering from any other diseases apart from breast cancer like diabetes, hypertension, thyroid illnesses and other sort of cancers are excluded from the study. For each of the study participant, age and sex matched controls were selected who were mostly the relatives of patients attending the hospital and were devoid of any illnesses. Venous blood sample was collected from all the patients as well as the controls that were used for determination of the levels of SOD (superoxide dismutase) and MDA (malondialdehyde). Written informed consent was taken from all the study participants before drawing the blood samples.Results: Authors have measured the markers of oxidative stress in breast cancer patients after diagnosis of breast cancer and compared theses blood levels with those of the controls. The mean MDA (nmol/ml) levels for the breast cancer patients and the controls were 26.14 and 15.83 respectively, while the SOD (U/gm Hb) levels were 0.12 and 0.16 respectively and the difference of the mean were statistically significant (p value <0.01).Conclusions: There is presence of increased oxidative stress in breast cancer patients as compared to the healthy controls.

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Impact of Breast Cancer and Combination Chemotherapy on Oxidative Stress, Hepatic and Cardiac Markers

Cited by 37 publications

References 25 publications

Study of Serum Lactate Dehydrogenase and Gamma-Glutamyl Transpeptidase in Breast Cancer Patients receiving Chemotherapy

Study of Serum Lactate Dehydrogenase and Gamma-Glutamyl Transpeptidase in Breast Cancer Patients receiving Chemotherapy

Influence of oxidative injury and monitoring of blood plasma by DSC on breast cancer patients

Assessment of oxidative stress in breast cancer patients: a hospital based study

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