Impact of Body Mass Index on 5-Year Clinical Outcomes in Patients With ST–Segment Elevation Myocardial Infarction After Everolimus-Eluting or Bare-Metal Stent Implantation

Moscarella, Elisabetta; Spitaleri, Giosafat; Brugaletta, Salvatore; Farrarons, Sara Sentí; Pernigotti, Alberto; Ortega‐Paz, Luis; Cequier, Ángel; Íñiguez, Andrés; Serra, Antonio; Jiménez‐Quevedo, Pilar; Mainar, Vicente; Campo, Gianluca; Tespili, Maurizio; Heijer, Peter den; Bethencourt, Armando; Vázquez, Nicolás; Valgimigli, Marco; Serruys, Patrick W.; Sabaté, Manel

doi:10.1016/j.amjcard.2017.07.040

Cited by 21 publications

(14 citation statements)

References 25 publications

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“…This further emphasizes the influence of frailty, which is in line with findings of previous reports. [26][27][28] In general, higher BMI and obesity are associated with cardiovascular risk factors such as hypertension, diabetes mellitus, and dyslipidemia. 29 However, a markedly lower BMI was related to a poor outcome following PCI in octogenarian patients with STEMI, which is possibly related to cardiac cachexia, malnutrition, or depression, as previously reported.…”

Section: 67mentioning

confidence: 99%

Influence of Preadmission Frailty on Short- and Mid-Term Prognoses in Octogenarians With ST-Elevation Myocardial Infarction

Yoshioka

Takagi

Morishima

et al. 2019

Circ J

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STEMI receiving PCI has not been evaluated sufficiently with regard to overall mortality and non-home discharge. The aim of this study was to evaluate the association of CFS with these clinical outcomes of octogenarian patients with STEMI. Methods Study Design and Population We screened the Nagoya multicenter registry for the data of consecutive patients with STEMI who underwent primary PCI between January 2014 and December 2016 (n=1,301). The registry is an ongoing, retrospective, multicenter registry of coronary artery disease and current data include information from 5 institutions in the Tokai area, details of which have been described previously. 10 Of the

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Section: 67mentioning

confidence: 99%

Influence of Preadmission Frailty on Short- and Mid-Term Prognoses in Octogenarians With ST-Elevation Myocardial Infarction

Yoshioka

Takagi

Morishima

et al. 2019

Circ J

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“…Joyce et al [29] reported that 51% of patients were overweight, 30% had normal body weight, and 19% people were obese. Similarly, in the study by Moscarella et al [27], overweight patients amounted to nearly half (49.4%) of the group with NSTEMI, obese patients -22.4% and people with normal BMI -28.2%. This paper focuses mainly on results obtained during the observational study in patients with low body mass (BMI < 18.5 kg/m 2 ).…”

Section: Discussionmentioning

confidence: 58%

“…In other work, the average BMI value reported in groups of patients with TS was even lower: 21.4 kg/m 2 in the study by Shiomura et al [26]. The average BMI in patients with acute coronary syndromes was 27.3 kg/m 2 in the study by Moscarella et al [27] and in the meta-analysis performed by Lamelas et al [28].…”

Section: Discussionmentioning

confidence: 84%

“…Even though the lowest mortality after 5 years was reported in overweight patients (15.2%), this value remains higher than in patients with acute coronary syndromes observed during a comparable follow-up period. Moscarella et al [27] stated that after a 5-year follow-up period 9.5% of overweight patients were dead, slightly more patients with BMI < 25 -13.7% and the smallest number of obese patients with STEMI -6.3%. Joyce et al [29] noted similar results obtained during a 5-year follow-up of patients after STEMI, as 13.6% of patients who were underweight or had normal body weight, and 9.1% of overweight and obese patients died.…”

Section: Discussionmentioning

confidence: 99%

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Takotsubo syndrome – fatal prognosis of patients with low body mass index in 5-year follow-up

Zalewska-Adamiec¹,

Małyszko²,

Bachórzewska−Gajewska³

et al. 2020

aoms

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Introduction: The clinical courses of takotsubo syndrome (TS) and of acute coronary syndromes (ACS) seem to be very similar. However, there is limited knowledge about risk factors of poor outcomes. Low body mass index worsens the prognosis of patients with cardiovascular diseases, especially those undergoing surgical treatment. The aim of the study was to evaluate the influence of the body mass index (BMI) on the prognosis in patients diagnosed with TS. Material and methods: Eighty patients aged 15-89 (mean: 67.9 years), 74 women and 6 men with TS diagnosis according to Mayo Clinic diagnostic criteria were divided into 3 groups: low body mass (BMI < 18.5 kg/m 2), normal body mass (18.5 ≥ BMI < 25 kg/m 2) and excessive body mass (BMI ≥ 25 kg/m 2). Results: Patients with low BMI were older, but with less prevalent risk factors such as hypertension, hypercholesterolemia and positive family history of coronary artery disease and more frequent risk factors such as cigarette smoking, chronic obstructive pulmonary disease (COPD), depressive and anxiety disorders as well as malignancy. They also had higher haemoglobin, lower troponin, creatine kinase, C-reactive protein and lipid fractions. The highest annual, 3-year and 5-year mortality was observed in the group with BMI < 18.5 kg/m 2. None of the patients with low BMI survived the 5-year follow-up period (100% vs. 25% vs. 15.2%; p < 0.0001). In group III, mortality among overweight patients (25 ≥ BMI < 30 kg/m 2) was 8.3%, and in obese people (BMI ≥ 30 kg/m 2) 1 out 5 patients died during follow-up. Conclusions: The majority of typical cardiovascular risk factors are less frequently observed in patients with TS and low body mass. Early prognosis for TS patients and low BMI is relatively favourable, whereas the 5-year follow-up is associated with extremely high mortality. Overweight patients have the best prognosis in the long-term follow-up.

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“…Existing data shows wide variation in mortality reflecting distinct differences between randomized controlled trials with pre-specified exclusion criteria and "real-life" populations, which include consecutive patients independently of co-morbidities, ethnicity, age and gender. In randomized controlled trials of invasively treated STEMI patients, the 5-year mortality rate in STEMI may be as low as 10% [10]. The Global Registry of Acute Coronary Events (GRACE) study is widely acknowledged and has had significant im- Either isolated or in association with 1-, 2-or 3-vessel disease pact on risk stratification in ACS [11].…”

Section: Randomized Clinical Trials and The Real-life Setting In Acs:mentioning

confidence: 99%

Poor long-term outcome in acute coronary syndrome in a real-life setting: Ten-year outcome of the TACOS study

et al. 2021

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Background: Long-term outcome of the three categories of acute coronary syndrome (ACS) in real-life patient cohorts is not well known. The objective of this study was to survey the 10-year outcome of an ACS patient cohort admitted to a university hospital and to explore factors affecting the outcome. Methods: A total of 1188 consecutive patients (median age 73 years) with ST-elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI) or unstable angina pectoris (UA) in 2002-2003 were included and followed up for ≥ 10 years. Results: Mortality for STEMI, NSTEMI and UA patients during the follow-up period was 52.5%, 69.9% and 41.0% (p < 0.001), respectively. In multivariable Cox regression analysis, only age and creatinine level at admission were independently associated with patient outcome in all the three ACS categories when analyzed separately. Conclusions: All the three ACS categories proved to have high mortality rates during long-term followup in a real-life patient cohort. NSTEMI patients had worse outcome than STEMI and UA patients during the whole follow-up period. Our study results indicate clear differences in the prognostic significance of various demographic and therapeutic parameters within the three ACS categories.

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Impact of Body Mass Index on 5-Year Clinical Outcomes in Patients With ST–Segment Elevation Myocardial Infarction After Everolimus-Eluting or Bare-Metal Stent Implantation

Cited by 21 publications

References 25 publications

Influence of Preadmission Frailty on Short- and Mid-Term Prognoses in Octogenarians With ST-Elevation Myocardial Infarction

Influence of Preadmission Frailty on Short- and Mid-Term Prognoses in Octogenarians With ST-Elevation Myocardial Infarction

Takotsubo syndrome – fatal prognosis of patients with low body mass index in 5-year follow-up

Poor long-term outcome in acute coronary syndrome in a real-life setting: Ten-year outcome of the TACOS study

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