Impact of blood flow on diffusion coefficients of the human kidney: A time‐resolved ECG‐triggered diffusion‐tensor imaging (DTI) study at 3T

Heusch, Philipp; Wittsack, Hans‐Jörg; Kröpil, Patric; Blondin, D.; Quentin, Michael; Klasen, Janina; Pentang, Gael; Antoch, Gerald; Lanzman, Rotem S.

doi:10.1002/jmri.23751

Cited by 37 publications

(33 citation statements)

References 19 publications

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“…Dual‐kidney targeted field of view (TFOV D) for multiple subjects. (a–d) Slices 3–11 of the kidneys are shown for four subjects . For each subject, the greyscale fractional anisotropy (FA) and colour FA (cFA) images are shown.…”

Section: Resultsmentioning

confidence: 99%

High‐resolution diffusion tensor imaging of the human kidneys using a free‐breathing, multi‐slice, targeted field of view approach

et al. 2014

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Fractional anisotropy (FA) obtained by diffusion tensor imaging (DTI) can be used to image the kidneys without any contrast media. FA of the medulla has been shown to correlate with kidney function. It is expected that higher spatial resolution would improve the depiction of small structures within the kidney. However, the achievement of high spatial resolution in renal DTI remains challenging as a result of respiratory motion and susceptibility to diffusion imaging artefacts. In this study, a targeted field of view (TFOV) method was used to obtain high-resolution FA maps and colour-coded diffusion tensor orientations, together with measures of the medullary and cortical FA, in 12 healthy subjects. Subjects were scanned with two implementations (dual and single kidney) of a TFOV DTI method. DTI scans were performed during free breathing with a navigator-triggered sequence. Results showed high consistency in the greyscale FA, colour-coded FA and diffusion tensors across subjects and between dual- and single-kidney scans, which have in-plane voxel sizes of 2 × 2 mm2 and 1.2 × 1.2 mm2, respectively. The ability to acquire multiple contiguous slices allowed the medulla and cortical FA to be quantified over the entire kidney volume. The mean medulla and cortical FA values were 0.38 ± 0.017 and 0.21 ± 0.019, respectively, for the dual-kidney scan, and 0.35 ± 0.032 and 0.20 ± 0.014, respectively, for the single-kidney scan. The mean FA between the medulla and cortex was significantly different (p < 0.001) for both dual- and single-kidney implementations. High-spatial-resolution DTI shows promise for improving the characterization and non-invasive assessment of kidney function. © 2014 The Authors. NMR in Biomedicine published by John Wiley & Sons, Ltd.

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Section: Resultsmentioning

confidence: 99%

High‐resolution diffusion tensor imaging of the human kidneys using a free‐breathing, multi‐slice, targeted field of view approach

et al. 2014

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“…In contrary to the subsequent data acquisition presented by Ho et al, in our study both datasets were acquired simultaneously on an integrated PET/MRI system, thus minimizing potential misregistration artifacts and potential biological changes. Furthermore, ADC quantifications are known to be highly susceptible to general physical alterations based on the choice of b-values, tissue perfusion, scanner geometry and field strength [45],[46].…”

Section: Discussionmentioning

confidence: 99%

Correlation of Standardized Uptake Value and Apparent Diffusion Coefficient in Integrated Whole-Body PET/MRI of Primary and Recurrent Cervical Cancer

et al. 2014

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BackgroundTo evaluate a potential correlation of the maximum standard uptake value (SUVmax) and the minimum apparent diffusion coefficient (ADCmin) in primary and recurrent cervical cancer based on integrated PET/MRI examinations.Methods19 consecutive patients (mean age 51.6 years; range 30–72 years) with histopathologically confirmed primary cervical cancer (n = 9) or suspected tumor recurrence (n = 10) were prospectively enrolled for an integrated PET/MRI examination. Two radiologists performed a consensus reading in random order, using a dedicated post-processing software. Polygonal regions of interest (ROI) covering the entire tumor lesions were drawn into PET/MR images to assess SUVmax and into ADC parameter maps to determine ADCmin values. Pearson’s correlation coefficients were calculated to assess a potential correlation between the mean values of ADCmin and SUVmax.ResultsIn 15 out of 19 patients cervical cancer lesions (n = 12) or lymph node metastases (n = 42) were detected. Mean SUVmax (12.5±6.5) and ADCmin (644.5±179.7×10−5 mm2/s) values for all assessed tumor lesions showed a significant but weak inverse correlation (R = −0.342, p<0.05). When subdivided in primary and recurrent tumors, primary tumors and associated primary lymph node metastases revealed a significant and strong inverse correlation between SUVmax and ADCmin (R = −0.692, p<0.001), whereas recurrent cancer lesions did not show a significant correlation.ConclusionsThese initial results of this emerging hybrid imaging technique demonstrate the high diagnostic potential of simultaneous PET/MR imaging for the assessment of functional biomarkers, revealing a significant and strong correlation of tumor metabolism and higher cellularity in cervical cancer lesions.

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“…To the best of our knowledge, the robustness and repeatability of DWI has not been investigated in NSCLC lesions so far. Several factors may affect ADC quantification, for example the choice of b-values, tissue perfusion [36] or scanner geometry and field strengths [37]. Therefore, the ADC values reported for different cancer types might exhibit significant variations.…”

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Correlation of the Apparent Diffusion Coefficient (ADC) with the Standardized Uptake Value (SUV) in Hybrid 18F-FDG PET/MRI in Non-Small Cell Lung Cancer (NSCLC) Lesions: Initial Results

Heusch¹,

Buchbender²,

Köhler

et al. 2013

Fortschr Röntgenstr

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Purpose: To compare the apparent diffusion coefficient (ADC) in non-small cell lung cancer lesions with standardized uptake values (SUV) derived from combined 18F-fluoro-deoxy-glucose-positron emission tomography/magnetic resonance imaging (FDG-PET/MRI) and those derived from FDG-PET/CT. Materials and Methods: In 18 consecutive patients with histologically proven NSCLC (17 men, 1 woman; mean age, 61???12 years), whole-body FDG-PET/MRI was performed after whole-body FDG-PET/CT. Regions of interest (ROI) encompassing the entire primary tumor were drawn into FDG-PET/CT and FDG-PET/MR images to determine the maximum and mean standardized uptake value (SUVmax; SUVmean) and into ADC parameter maps to assess mean ADC values. Pearson?s correlation coefficients were calculated to compare SUV and ADC values. Results: The SUVmax of NSCLC was 12.3???4.8 [mean ?SD], and the SUVmean was 7.2???2.8 as assessed by FDG-PET/MRI. The SUVmax and SUVmean derived from FDG-PET/CT and FDG-PET/MRI correlated well (R?=?0.93; p?

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Impact of blood flow on diffusion coefficients of the human kidney: A time‐resolved ECG‐triggered diffusion‐tensor imaging (DTI) study at 3T

Abstract: ADC-values in the renal cortex as well as FA-values in the renal medulla are influenced by renal blood flow. This impact has to be considered when interpreting renal ADC- and FA-values.

Cited by 37 publications

References 19 publications

High‐resolution diffusion tensor imaging of the human kidneys using a free‐breathing, multi‐slice, targeted field of view approach

High‐resolution diffusion tensor imaging of the human kidneys using a free‐breathing, multi‐slice, targeted field of view approach

Correlation of Standardized Uptake Value and Apparent Diffusion Coefficient in Integrated Whole-Body PET/MRI of Primary and Recurrent Cervical Cancer

Correlation of the Apparent Diffusion Coefficient (ADC) with the Standardized Uptake Value (SUV) in Hybrid 18F-FDG PET/MRI in Non-Small Cell Lung Cancer (NSCLC) Lesions: Initial Results

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