Impact of Bipolar Disorder on a U.S. Community Sample

Calabrese, Joseph R.; Hirschfeld, Robert M. A.; Reed, Michael L.; Davies, Marilyn A.; Frye, Mark A.; Keck, Paul E.; Lewis, Lydia; McElroy, Susan L.; McNulty, James; Wagner, Karen Dineen

doi:10.4088/jcp.v64n0412

Cited by 237 publications

(153 citation statements)

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“…Young people screened in late adolescence and early adulthood report high rates of hypomanic experiences (Chandler et al, 2008;Calabrese et al, 2003) and these experiences are associated with increased rates of mood and anxiety disorders in adulthood including BD (Lewinsohn et al, 2000;Tijssen et al, 2010). Individuals with the BPP are at increased risk for a range of mental health problems.…”

Section: Discussionmentioning

confidence: 99%

“…Although studies in this population have indisputably helped to inform current understanding of the BDs, they are nonetheless limited by the confounding factors inherent in studying a chronically ill population; for example, the effects of long-term medication, multiple hospitalizations, comorbidities, cognitive impairment, and long disease histories. Recent research has sought to eliminate these confounds by studying at-risk individuals for BD, identified on the basis of previous hypomanic experiences (Chandler et al, 2008;Calabrese et al, 2003). Such individualsFhereafter referred to as individuals with the bipolar phenotype (BPP)Fare at increased risk for a range of mental health problems including, but not limited to, BD (eg, anxiety, depression;Chandler et al, 2008;Calabrese et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…Recent research has sought to eliminate these confounds by studying at-risk individuals for BD, identified on the basis of previous hypomanic experiences (Chandler et al, 2008;Calabrese et al, 2003). Such individualsFhereafter referred to as individuals with the bipolar phenotype (BPP)Fare at increased risk for a range of mental health problems including, but not limited to, BD (eg, anxiety, depression;Chandler et al, 2008;Calabrese et al, 2003). Moreover, among individuals with the BPP some already meet DSM-IV-TR criteria for bipolar II or NOS (Rock et al, 2010;Chandler et al, 2009) and their symptoms and alterations in emotional processing are relatively homogeneous.…”

Section: Introductionmentioning

confidence: 99%

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Reduced Subjective Response to Acute Ethanol Administration Among Young Men with a Broad Bipolar Phenotype

Yip

Doherty

Wakeley

et al. 2012

Neuropsychopharmacol

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Elevated lifetime prevalence rates of alcohol use disorders (AUDs) are a feature of bipolar disorder (BD). Individuals at-risk for AUDs exhibit blunted subjective responses to alcohol (low levels of response), which may represent a biomarker for AUDs. Thus, individuals atrisk for BD may exhibit low responses to alcohol. Participants were 20 unmedicated adult males who reported high rates of hypomanic experiences (bipolar phenotype participants; BPPs), aged 18 to 21 years, and 20 healthy controls matched on age, gender, IQ, BMI, and weekly alcohol intake. Subjective and pharmacokinetic responses to acute alcohol (0.8 g/kg) vs placebo administration were collected in a randomized, double-blind, cross-over, placebo-controlled, within-subjects design. BPP participants reported significantly lower subjective intoxication effects ('feel high': F ¼ 14.2, p ¼ 0.001; 'feel effects': F ¼ 8.1, p ¼ 0.008) across time, but did not differ in their pharmacokinetic, stimulant, or sedative responses. Paradoxically, however, the BPP participants reported significantly higher expectations of the positive effects of alcohol than controls. Our results suggest that unmedicated young males with previous hypomanic experiences exhibit diminished subjective responses to alcohol. These blunted alcohol responses are not attributable to differences in weekly alcohol intake, pharmacokinetic effects (eg, absorption rates), or familial risk of AUDs. These observations suggest that the dampened intoxication may contribute to the increased rates of alcohol misuse in young people at-risk for BD, and suggest possible shared etiological factors in the development of AUDs and BD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Reduced Subjective Response to Acute Ethanol Administration Among Young Men with a Broad Bipolar Phenotype

Yip

Doherty

Wakeley

et al. 2012

Neuropsychopharmacol

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“…Número de estudios: 11 estudios controlados 20,23,24,26,28,30,[61][62][63][64][65] y 10 no controlados 34,[36][37][38]49,[66][67][68][69][70] .…”

Section: Patología Neurológicaunclassified

Consenso Español de Salud Física del Paciente con Trastorno Bipolar

Bobes

Ruiz

Montes

et al. 2008

Revista de Psiquiatría y Salud Mental

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ResumenIntroducción y objetivos: Los pacientes con trastorno bipolar presentan una morbilidad físi-ca y una mortalidad muy superior a la de la población general. Además de una mayor mortalidad por suicidio, tienen también una mayor prevalencia de enfermedades físicas. El objetivo de este consenso, promovido por las Sociedades Españolas de Psiquiatría y Psiquiatría Biológica, en colaboración con las sociedades de médicos de asistencia primaria, es establecer recomendaciones prácticas sobre los procedimientos de detección, prevención e intervención en las enfermedades somáticas que coexisten con el trastorno bipolar para mejorar la calidad y esperanza de vida de estos pacientes. Método: Las Sociedades Españolas de Psiquiatría y Psiquiatría Biológica eligieron un ComitéCientífico que seleccionó a su vez a 32 psiquiatras expertos y 10 médicos expertos en otras especialidades médicas. Se crearon grupos de trabajo para cada especialidad con la finalidad de adaptar las guías aplicadas en la población general a pacientes con trastorno bipolar. Partiendo de una revisión sistemática sobre la comorbilidad médica y la mortalidad en el trastorno bipolar se realizaron dos reuniones para acordar el consenso. Resultados: En la revisión bibliográfica se detectó un riesgo aumentado, entre los pacientes con trastorno bipolar, de presentar hipertensión arterial, obesidad, tabaquismo, enfermedades pulmonares, migraña e infección por virus de la inmunodeficiencia humana (VIH). También se encontró evidencia de un aumento de mortalidad por enfermedades cardiovasculares, respiratorias e infecciones, además del suicidio. El grupo de expertos alcanzó el consenso en una serie de medidas básicas para la detección de comorbilidad médica aplicables a la monitorización de estos pacientes. Las recomendaciones resultantes serán asumidas y divulgadas por las sociedades promotoras. Conclusiones: El decálogo generado en el Consenso Español de Salud Física del Paciente con Trastorno Bipolar recoge los aspectos más relevantes para la mejora del funcionamiento psicosocial, la calidad y la esperanza de vida en los pacientes con esta patología.

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“…Consequences of misdiagnosis include worsening of the disease, iatrogenic treatment with antidepressants, increased risk of suicide, alcoholism, drug addiction, risk of contracting sexually transmitted diseases (mainly AIDS), and litigations. 6,7 Bipolar disorder type II (BD-II) is a common disorder, affecting around 3-5% of the adult population worldwide, with estimates of up to 11% for bipolar spectrum disorders. 8 In Brazil, the lifetime prevalence is 8.3% for the bipolar spectrum.…”

Section: Introductionmentioning

confidence: 99%

Reliability and validity of a Brazilian version of the Hypomania Checklist (HCL-32) compared to the Mood Disorder Questionnaire (MDQ)

Soares

Moreno

Moura

et al. 2010

Rev. Bras. Psiquiatr.

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Objective: Bipolar disorders are often not recognized and undertreated. The diagnosis of current or past episodes of hypomania is of importance in order to increase diagnostic certainty. The Hypomania Checklist-32 is a self-applied questionnaire aimed at recognizing these episodes. As part of the international collaborative effort to develop multi-lingual versions of the Hypomania Checklist-32, we aimed to validate the Brazilian version and to compare its psychometric properties with those of the Mood Disorder Questionnaire. Method: Adult outpatients with bipolar disorder I (n = 37), bipolar disorder II (n = 44) and major depressive disorder (n = 42) of a specialized mood disorder unit were diagnosed according to DSM-IV-TR using a modified version of the SCID. We analyzed the internal consistency and discriminative ability of the Hypomania Checklist-32 Brazilian version in relation to the Mood Disorder Questionnaire. Results: The internal consistency of the Brazilian Hypomania Checklist-32, analyzed using Cronbach's alpha coefficient, was 0.86. A score of 18 or higher in the Hypomania Checklist-32 Brazilian version distinguished between bipolar disorder and major depressive disorder, with a sensitivity of 0.75 and a specificity of 0.58, compared to 0.70 and 0.58, respectively, for the Mood Disorder Questionnaire (score ≥ 7). The Hypomania Checklist-32 Brazilian version showed a dual factor structure characterized by "active/elated" and "risk-taking/ irritable" items. Hence, the Hypomania Checklist-32 Brazilian version was found to have a higher sensitivity but the same specificity as the Mood Disorder Questionnaire. Conclusion: The Brazilian version of the Hypomania Checklist-32 has adequate psychometric properties and helps discriminating bipolar disorder from major depressive disorder (but not bipolar disorder I from bipolar disorder II) with good sensitivity and specificity indices, similar to those of the Mood Disorder Questionnaire. Resumo Objetivo: O transtorno bipolar muitas vezes não é reconhecido e deixa de ser tratado adequadamente. O diagnóstico de episódios atuais ou passados é importante, a fim de aumentar a certeza diagnóstica. O Questionário de Autoavaliação de Hipomania-32 é um questionário autoaplicável para o rastreamento desses episódios. Como parte do desenvolvimento em vários idiomas do Questionário de Autoavaliação de Hipomania-32, nós objetivamos validar a versão brasileira e comparar suas propriedades psicométricas com o Questionário de Transtornos do Humor. Método: Em uma unidade especializada em transtornos do humor foram selecionados pacientes ambulatoriais adultos com transtorno bipolar I (n = 37), transtorno bipolar II (N = 44) e transtorno depressivo maior (N = 42) de acordo com a DSM-IV-TR

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Impact of Bipolar Disorder on a U.S. Community Sample

Cited by 237 publications

References 0 publications

Reduced Subjective Response to Acute Ethanol Administration Among Young Men with a Broad Bipolar Phenotype

Reduced Subjective Response to Acute Ethanol Administration Among Young Men with a Broad Bipolar Phenotype

Consenso Español de Salud Física del Paciente con Trastorno Bipolar

Reliability and validity of a Brazilian version of the Hypomania Checklist (HCL-32) compared to the Mood Disorder Questionnaire (MDQ)

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